Dude, Phil, you can’t out-study Infectious Disease. Don’t even try.
Our latest video in our partnership with @DGlaucomflecken summarizes the AZ-SWED trial that evaluated whether a 5-day course of azithromycin decreases the severity of illness in young children with wheezing. Read the full study for free: nej.md/DrG44
#pediatrics
Ivan retweeted
Hi, Chemist here.
Some people think chemistry is just about what atoms a molecule contains.
It isn’t.
It’s also about how those atoms are arranged in 3D space.
The active ingredient in a Vicks inhaler is L-methamphetamine.
Street meth is D-methamphetamine.
Same atoms.
Same bonds.
One subtle change in three-dimensional shape.
One clears your nose.
The other powerfully stimulates your brain.
That’s why chemists don’t judge molecules by their names.
Structure determines function.
Dose makes the poison.
Original Article: Daraxonrasib or Chemotherapy in Previously Treated Metastatic Pancreatic Cancer (phase 3 RASolute 302 trial) nej.md/4nWaxvM
#ASCO26 | @ASCO

ALT A two-panel line graph shows overall survival in two populations, comparing darovasertib (blue line) and chemotherapy (gray line) treatments. Panel A depicts the RAS G12 population, while Panel B shows the overall population. Hazard ratios and confidence intervals are detailed in each panel.

ALT This image shows two line graphs titled "Progression-free Survival in the RAS G12 Population" and "Progression-free Survival in the Overall Population." Both graphs compare survival rates over 13 months between two groups: one receiving darovasertib and the other receiving chemotherapy. Accompanying the graphs are tables detailing the number of events and patients at risk for each treatment group.
Ivan retweeted
For decades, biology textbooks have enshrined a simple rule: DNA is made by copying a template. After one enzyme unzips a DNA double helix into separate strands, another called a polymerase builds a complementary sequence, base by base, for each strand. Presto: two copies of the original DNA.
But new research into how bacteria defend themselves from viruses now shows this synthesis rule isn’t absolute.
Now, a team describes a bacterial enzyme that synthesizes DNA without a nucleic acid template, using its own structure as a guide.
Learn more: scim.ag/4tTc5IA @NewsfromScience
Loved every single word ! Thank you
Replying to @liz_churchill10
No. This is a misunderstanding of how influenza vaccines work, mixed with a bit of conspiracy theatre.
First, 25% effectiveness does not mean the vaccine only works 25% of the time.
That’s not how vaccine effectiveness is measured. It means that vaccinated people had about a 25% lower risk of getting medically attended influenza compared with unvaccinated people during that season. In other words, it still prevented a substantial number of infections.
Second, influenza viruses mutate constantly. Some years the circulating strains match the vaccine well and effectiveness can be 50–60% or higher. Other years the match is poorer and effectiveness drops. That’s a known biological reality of influenza evolution, not evidence of a conspiracy.
Third, and this is the part people conveniently ignore, the flu vaccine’s most important benefit is reducing severe disease, hospitalisation, and death, even in years with modest effectiveness. Studies repeatedly show vaccinated people are far less likely to end up in ICU or die from influenza.
Fourth, the “vaccine cartel making billions” claim collapses the moment you look at the numbers. Vaccines account for a small fraction of pharmaceutical revenue compared with chronic disease drugs. If the industry wanted maximum profit, preventing disease would actually be the worst business model imaginable.
Finally, calling for arrests because a seasonal vaccine didn’t perfectly match a rapidly mutating virus shows a profound misunderstanding of basic virology and epidemiology.
Influenza vaccines are updated every year precisely because the virus evolves. That’s not fraud. That’s science responding to biology in real time.
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Ivan retweeted
In questi giorni ricordiamo questa riflessione di Piero Angela:.
“Noi siamo lì, in quella pallina che non conta niente, nel buio dell’universo. E lì, sotto questa atmosfera così sottile, noi continuiamo a prenderci a mazzate.
Questo ci dà una regolata su cosa dovremmo essere”.
Ivan retweeted
Sgomento dalle polemiche sulla #giornatadellamemoria
Non comprendiamo che ciò che dobbiamo ricordare
è che ciascuno di noi,
accecato da un'ideologia,
può essere un mostro
e lasciar sterminare innocenti,
solo perché nati nigeriani, palestinesi, indù, ucraini, cristiani, ebrei...
Ivan retweeted
A 17 year old child.
A
17
Year
Old
Child!!
This is some fucked up shit. This poor kid is going to scarred and scared for life. Especially, during this Nazi regime.
This man's heart broke during this video, and I cannot blame him. This is saddening.
👇👇👇👇
Ivan retweeted
The mechanism by which low dose aspirin can help prevent cancer metastasis @NEJM
With particular reference to colon cancer and individuals with specific mutations or CHIP
nejm.org/doi/full/10.1056/NE…
Ivan retweeted
🤯
New in @Nature from @MDAndersonNews colleagues @adam_grippin @StevenLin_MDPhD
SARS-CoV-2 mRNA vaccines sensitize tumors to immune checkpoint blockade
nature.com/articles/s41586-0…
Ivan retweeted
Low-Dose Aspirin for PI3K-Altered Localized Colorectal Cancer
@NEJM
doi.org/10.1056/NEJMdo008154
👉Low-dose aspirin resulted in a significantly lower risk of recurrence w/ hotspot mutations
👉similar benefit w/ other alterations in PI3K pathway
🧐I would take it...
@myESMO
























