NHMRC Emerging Leadership Fellow | Postdoctoral Research Officer | Translational Neurogenomics Lab @QIMRBerghofer | Psychiatric Genetics
Joined March 2013
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Jackson Thorp retweeted
You've heard of DNA, but what about GNA? New preprint from @jacksonthorp and IBG member Andrew Grotzinger that introduces Genomic Network Analysis (GNA), an open-source multivariate tool for performing network analysis using GWAS summary statistics medrxiv.org/content/10.1101/…
Our review of the genetics of substance use disorders is out now in @molpsychiatry
@zac_gerring, @DerksEske, Jorien Treur, Karin Verweij
nature.com/articles/s41380-0…
We are hiring postdocs! Join the @DerksEske lab in warm and sunny Brisbane! Get in touch if you are interested in 1) multivariate genetic modelling of psychiatric/related traits; and/or 2) functional interpretation of GWAS loci/drug repurposing. More info seek.com.au/job/75121783?ref…
Jackson Thorp retweeted
An exciting study by Burstein et al. investigated the genetics of binge eating disorder. We discuss the main findings of their work
nature.com/articles/s41588-0…
@zac_gerring @jacksonthorp @QIMRBerghofer @NatureGenet
Our new paper identifying drug repurposing candidates for anxiety is out now! authors.elsevier.com/c/1hRPH…
Big congrats to @DWoodward92 for his first publication. Many more great papers to come.
My first publication is now out in Psychiatry Research! Investigating drug repurposing candidates for treatment in anxiety. Huge thanks to co-authors @zac_gerring @DerksEske @jacksonthorp @AkosileWole @egamazon & Jue-Sheng Ong @QIMRBerghofer
authors.elsevier.com/c/1hRPH…
Jackson Thorp retweeted
Ever wondered how many symptoms make up all of adult psychopathology described in the DSM-5? It’s 628!
How many do you think repeat across multiple diagnoses? If you answered 231 symptoms repeating a total of 1022 times (median 3 times per symptom, range 2-22), good job!
🧵
ALT A plot of the repetition among the symptoms in the DSM-5 showing substantial overlap within and between chapters of diagnoses. 202 primary disorders and specifiers are represented, and diagnostic criteria have been split into a list of 1419 constituent symptoms. Each dot on the circumference is a symptom; its size represents symptom frequency. Lines linking symptoms map the repetition among diagnoses within and between chapters.
The last of my PhD papers is now published!
We looked at the association between depression PRS, trauma exposure, their interaction, and individual depression symptoms @PsychiatryResJ
Big thanks to @DerksEske @zac_gerring and all co-authors
authors.elsevier.com/a/1gZoD…
Jackson Thorp retweeted
Today, our paper on attrition and selection using data from the Australian Genetics of Depression study was published. (1/8) doi.org/10.1007/s00406-022-0…
Our article summarising some of the key challenges for the field of psychiatric genetics is out now in @NatureGenet. As always, an absolute pleasure to write this with @DerksEske and @zac_gerring
@QIMRBerghofer
nature.com/articles/s41588-0…
Jackson Thorp retweeted
In a slight shift in focus, our most recent study, published today in @NatureComms, was a large GWAS meta-analysis of acne. Using data from 9 research centers around the globe we were able to identify 46 variants associated with acne risk (29 novel).
Better understanding of the genetic basis of acne can pave the way to more effective treatments. Here, the authors perform a genome-wide association study meta-analysis of >20,000 cases and identify 29 new acne susceptibility loci
nature.com/articles/s41467-0…
Jackson Thorp retweeted
Very proud of this piece of work where we look at the aetiology of antidepressant side effects in a large sample:
nature.com/articles/s43856-0…
Jackson Thorp retweeted
Our preprint exploring sociodemographic and genetic factors linked to optional prescription record linkage in the AGDS is out! Thanks to everyone involved in this important study!
Phenotypic and genetic factors associated with differential consent to record linkage for prescription history in the Australian Genetics of Depression Study medrxiv.org/cgi/content/shor… #medRxiv
Jackson Thorp retweeted
Excited about my new preprint where we looked at genetic evidence of correlation and potential causal relationships between a panel of ~ 50 blood based biochemical markers and 10 psychiatric traits. @MurrayCairns @miffyjayne @HMRIAustralia @Uni_Newcastle. Short tweetorial 1/13
Genetic estimates of correlation and causality between blood-based biomarkers and psychiatric disorders medrxiv.org/cgi/content/shor… #medRxiv
Our paper modelling symptoms of anxiety, depression and neuroticism is now out in @NatureHumBehav
Link to paper: rdcu.be/ciK6a
Big thanks to @DerksEske @AdrianCamposG @zac_gerring @QIMRBerghofer
Symptom-level modelling unravels the shared genetic architecture of anxiety and depression buff.ly/32f2cdw From @jacksonthorp et al. @DerksEske
Jackson Thorp retweeted
Many psychiatric disorders and substance use outcomes share genetic effects. Controlling for genes associated with socio-economic outcomes changes the genetic relationships between these mental health outcomes. Our paper just out in @NatureHumBehav 🧬💸🧠
nature.com/articles/s41562-0…
Jackson Thorp retweeted
A systematic analysis of genetically regulated differences in gene expression and the role of co-expression networks across 16 psychiatric disorders and substance use phenotypes biorxiv.org/cgi/content/shor… #bioRxiv
Jackson Thorp retweeted
Faculty of Health @RealHealthM - Brittany Mitchell
Exploring the genetic relationship between hearing impairment and Alzheimer’s disease. eprints.qut.edu.au/206652/ #BrittanyMitchell
Jackson Thorp retweeted
PLEIO: a method to map and interpret pleiotropic loci with GWAS summary statistics cell.com/ajhg/fulltext/S0002…
Jackson Thorp retweeted
Happy Friday everyone! Our new pre-print is out! In it we explore how the genetic aetiology varies through systematic addition of components in a diagnosis of major depressive disorder (impairment, duration etc.). Welcome any thoughts!
medrxiv.org/content/10.1101/…
