@JExpMed

The Journal of Experimental Medicine publishes immunology, cancer, stem cells, microbial pathogenesis, vascular biology, neurobiology. Est. 1896 - @RockUPress

 New York, NY
jem.org
Joined September 2009
  • Tweets18.9K
  • Following1.2K
  • Followers35.4K
10.7KMedia
Chimeric MHC class I and II-restricted non-self epitopes broaden anti-tumor T cell reactions. From Rongsheng Zhang, Tasuku Honjo, Kenji Chamoto and colleagues: hubs.la/Q04BVWG_0 Part of our Immune #Tolerance collection 👉 hubs.la/Q04BVW_y0
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#Claudin 1-mediated positioning of DC1 to mTECs is essential for maintenance of central #tolerance. From Jiří Březina, Dominik Filipp and colleagues @CzechAcademy: hubs.la/Q04BVW_v0 Part of our Immune #Tolerance collection 👉 hubs.la/Q04BVX1h0
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Journal of Experimental Medicine retweeted
Addie Walsh@Addie_E_Walsh21h
My first-author paper is now live @JExpMed! We found that the Alzheimer's disease risk factor CASS4 is a critical regulator of amyloid beta plaque compaction, microglial mobilization to damage, and focal adhesion signaling. rupress.org/jem/article/223/…

Alzheimer’s genetic risk factor CASS4 controls microglial focal adhesion biology and amyloidosis

CASS4 is a genetic risk factor for Alzheimer’s disease but remains understudied in the brain. This study identifies CASS4 as a critical regulator of amyloi

rupress.org
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John Lukens@LukensJohnR21h
New study from our group @Addie_E_Walsh 👇 Alzheimer’s genetic risk factor CASS4 controls microglial focal adhesion biology and amyloidosis @JExpMed rupress.org/jem/article/223/… #Alzheimer
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CASS4 is a genetic risk factor for #Alzheimers disease but remains understudied in the brain. Walsh, @LukensJohnR et al. identify CASS4 as a critical regulator of amyloid β plaque compaction, microglial mobilization to damage, & focal adhesion signaling. hubs.la/Q04CtxKH0
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📽️ See a short video summary by the first author, Adeline E. Walsh: youtu.be/KXdNLjwme0I

The Alzheimer's genetic risk factor CASS4 controls microglial focal...

Original paper: [LINK]Video summary by Adeline E Walsh (John Luke...

youtube.com
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Ai-Ping Cao, Jun-Cheng Li, Rui Wang et al. reveal that the Vanin-pantethine-cholesterol axis acts as a metabolic checkpoint controlling #DendriticCell activation in autoimmune #inflammation. hubs.la/Q04CtwQ00 #Autoimmunity #Psoriasis
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See the accompanying Press Release: eurekalert.org/news-releases…

Researchers identify common nutritional supplement as potential treatment for psoriasis

Researchers in China have discovered that the vitamin B5 derivative pantethine limits the activity of immune cells that are key contributors to autoimmune diseases such as psoriasis. The study, to be...

eurekalert.org
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📰 #PressRelease: Researchers have discovered that the vitamin derivative pantethine prevents the development of #psoriasis in mice and helps alleviate patient symptoms in a small-scale human trial. hubs.la/Q04Cstk90 See the original JEM study: hubs.la/Q04CssYm0
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DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells. From Emily Siniscalco, Courtney Fisher, Meng-Ping Lu, Stephanie Eisenbarth, Uthaman Gowthaman and colleagues: hubs.la/Q04BVX1f0 Part of our Immune #Tolerance collection 👉 hubs.la/Q04BVWCV0
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Targeting Mettl8-Tcf1 axis promotes CD8⁺ TPEX differentiation and antitumor immunity. From Jiaxi Song, Dan Cui, Qizhao Huang, Jia Li, Fengyin Li, and colleagues: hubs.la/Q04BVWDv0 Part of our Immune #Tolerance collection 👉 hubs.la/Q04BVWH00
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Journal of Experimental Medicine retweeted
DeZio_Lab@melanomateamOct 26
Thrilled to share our new Review on how to make a cold tumor hot, published in the Journal of Experimental Medicine @RockUPress rupress.org/jem/article/223/…
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Marwa Saad, Angelina Bilate, Daniel Mucida et al. @RockefellerUniv show that colorectal tumors with distinct metastatic potential trigger divergent early T cell responses. hubs.la/Q04Cjl3H0 #SolidTumors #MucosalImmunology #TumorImmunology #ColonCancer #TCells
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Inhibitory receptor agonists: Emerging strategies in immune modulation. Review from Kieran R. Adam, Aamir Suhail, Vijay K. Kuchroo, and Dario A.A. Vignali: hubs.la/Q04BVW_w0 Part of our Immune #Tolerance collection 👉 hubs.la/Q04BVWB30
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B7 costimulation antagonizes RORγt+ regulatory #Tcells and immune #tolerance in the intestine. From Mengze Lyu and Gregory F. Sonnenberg: hubs.la/Q04BVWG20 Part of our Immune #Tolerance collection 👉 hubs.la/Q04BVWB40
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IgD from atypical-like memory #Bcells and #plasmacells targets commensal and environmental antigens. By @RoserTP, @HabibBashour, Filipska et al. (@victorgreiff & Cerutti labs): hubs.la/Q04BVWG40 Part of our Immune #Tolerance collection 👉 hubs.la/Q04BVW_z0
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PRECISE-seq reveals disease-relevant TCR repertoires with phenotypic plasticity. From Shibo Liu, Guanghao Liang, Yayun Yang, Yanyang Shi, Lihui Dong, Peng R. Chen, Meng Michelle Xu et al. hubs.la/Q04BVWDw0 Part of our Immune #Tolerance collection 👉 hubs.la/Q04BVWG60
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Regulatory T cells sabotage anti-tumor γδ #Tcells by creating IL-2–deficient environments. From @RafaelBlancoDom, @BSilva_Santos, Sofia Mensurado and colleagues: hubs.la/Q04BVWG30 Part of our Immune #Tolerance collection 👉 hubs.la/Q04BVWCS0
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eIF3e-mediated translational checkpoint maintains immune #tolerance and prevents lymphoid malignancy. From Zhengtao Xiao, Dieter A. Wolf, Wen-Hsien Liu, Changchun Xiao and colleagues: hubs.la/Q04BVWDt0 Part of our Immune #Tolerance collection 👉 hubs.la/Q04BVWCT0
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Our #Cytokines collection covers genetic susceptibility to infectious disease, environmental & evolutionary tuning of innate immune responses, neuroimmune regulation of tissue function, metabolic & transcriptional cell-fate control, & more 👉 hubs.la/Q04B0PHj0
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