Jonathan retweeted
wtf
this guy just had Claude Sonnet 5 perform brain surgery on a living mouse
the goal was to treat the mouse's epilepsy so it would stop having so many seizures.
here's what Claude did:
> it looked at 19 possible treatments and picked one that boosts the brain's natural calming chemical
> it chose where to inject it based on where these seizures are thought to start
> it worked out the exact injection point by averaging three research papers
> it lowered the needle 4.3 millimeters into the mouse's brain
> it injected a 20,000th of a teaspoon of the treatment over five minutes
> it checked the live camera 32 times to watch for things like bleeding
and the mouse woke up and recovered well!
interestingly, Opus 5.5 and Opus 5 both refused the task because it involved real biology
so Sonnet 5 got the job.
and as far as the researcher knows it's the first time an AI has picked a treatment and then injected it into the brain of a living mammal.
Last night an AI agent performed brain surgery on a mouse.
We gave it 19 gene therapy vectors in a spreadsheet, a mouse model of epilepsy, access to a motorize surgery rig with cameras and one goal: reduce seizures.
It picked the drug. It picked the brain region. It derived the coordinates from three papers. Then it drove the stereotaxic arms into the brain and injected 250 nanolitres while watching the entry site through the rig camera for bleeding.
A licensed vet gated every irreversible step and held a physical kill switch to stop the AI agent.
Thread on what it decided, what it saw, and the moment it refused to let me override it.
[Writing this on the spot out of excitement, but I've been 18hrs in front of my laptop coding and coordinating this, so keeping it brief and descriptive, more cohesive thoughts on this soon...]
Jonathan retweeted
Mijn inzending voor de ontwerpwedstrijd van NS voor een nieuwe spoorkaart van Nederland!
De uitdaging was om alle 400 stations en tientallen lijnen van verschillende vervoerders overzichtelijk op te nemen.
Een paar ontwerpkeuzes hieronder:
Jonathan retweeted
Big Almond has been doing this the whole time and we’ve been out here worried about data centers. Unbelievable.
Jonathan retweeted
Want to get better at Product Design? This free book by @WdeB is a very good start!
productdesignpsychology.com/
Jonathan retweeted
Keyboards are so 1983.
You only need one key—Monokey, the limited edition device that turns your voice into text in Monologue.
We're giving away 10, along with a free annual subscription to Monologue.
Jonathan retweeted
For anyone who hasn’t made the switch yet, the @ReadwiseReader read-it-later app is *phenomenal.*
The absolute best in the business and you should be using it!!
Wow! Saddened to hear that @Pocket (the biggest read-it-later app) is shutting down on July 8th.
You can import all of your pocket articles, highlights, etc into @ReadwiseReader with two clicks
Jonathan retweeted
Sign the Dutch petition for improving stock option law:
Nederlandse startups lopen achter door gebrekkige regelgeving voor aandelenopties. We hebben het talent, maar missen het vliegwiel. Teken de petitie!
vliegwiel.nl
Jonathan retweeted
Europe, it's time for action! 🇪🇺
Join our petition for an EU-Inc:
A pan-European startup entity
Goal:
- fix investments
- fix europe-wide employment
- fix stock options
- unite the European startup ecosystems
We got 6 weeks to make this real!
Sign here: eu-inc.org
Jonathan retweeted
So many have commented on my last post about people not having an inner monologue saying they have “aphantasia” or “mind blindness”. 🤯
Here is a simple test I found.
Close your eyes and picture a red star. How well can you see the star visually on a scale of 1 to 6?
Jonathan retweeted
As requested, added about 20 new designs based on popular icons to Apollo's merch store! Shirts, hoodies, hats, phone cases and more. 👕
The promo code "RIPAPOLLO" for 10% off plus free shipping is ending very soon too!
cottonbureau.com/people/apol…
Jonathan retweeted
Stats from yesterday’s @indieappsanta 🎁:
Downloads: 1.6K (1.22K + 397)
Sales: 2.0K (1.55K + 434)
(They were all far more than I expected, as a non-free deal 😳😳😻🎄☃️✨✨✨)
🎁0️⃣9️⃣🎁
@bluebird_app is a joyful and stress-free time management app. It combines a Pomodoro-style focus timer with a to-do list, helps people overcome procrastination, stay focused, and make progress. 🐦🍅
Bluebird Pro: $39.99 → $9.99 💵
By @limited_dfs & @topologiraffe
Jonathan retweeted
🎆The countdown is over – Big Mail is here!
✉️ Experience a totally reimagined, all native mail app for Mac, iPhone and iPad.
📲 Available now exclusively on the @AppStore.
💌 Try it free for 14 days, and RT for your chance to win a year of Big Mail getbigmail.com
Jonathan retweeted
🚨 GIVEAWAY TIME! 🚨
We're celebrating our latest milestone– 1000 happy customers– by giving away 3 lifetime subscriptions!
🪙 Valued at over $200
🌏 Open to anyone– trialing, existing & future users
📢 Follow @lunchmoney_app, like and RT to enter
Ends Mar 3, 23:59ET
Jonathan retweeted
Leuk draadje.
You’re unable to view this Post because this account owner limits who can view their Posts. Learn more
Jonathan retweeted
🦠 2020 really sucked for everyone so:
🎁 Giving away another ~$3,000 🍎 MacBook Pro 16" to a random person who retweets this tweet to cheer every1 up
👩🎨 Please make something creative with it
(you have to follow for winner DM)
Proof of last time: teapawt.net/JSXRDX/status/12225480…
This brand new MacBook Pro is for REAL!🤩
Amazing specs... 16" retina display, 1TB, 32GB RAM, i9 CPU & gfx card upgrade. Thank you @levelsio!!🙏🙏🙏
...it's time to unleash some creativity!✨
Jonathan retweeted
I'd rather spend $3000 on someone who can use it than wasting it on Twitter ads, so here we go
🎉New Year's Giveaway🍾
I'm giving away a new 🍏MacBook Pro 16" to a random person who retweets this tweet
👩🎨 Make something cool w/ it
(you have to follow because I want followers)
Jonathan retweeted
Paw — The most advanced API tool for Mac (REST & HTTP Client) paw.cloud/ · We're making a crazy Black Friday offer: Retweet to get a free Paw license (worth $49.99) 💰 · Or buy 50% from our website + all profits go to organizations fighting climate change 🌎






































