Student of evolution and explorer of enzymes. Biocatalysis, biosynthesis, genome mining, crystallography, science memes. SEA-ALW-LAX-ZRH-EWR. Him.

New Jersey
Joined March 2018
while I am excited about the prospects of AI in biomedicine, I’m not sure where these folks got the idea that the bottleneck was a lack of ideas.
Rosalind for new drug discovery ideas:
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Wherein a couple of tech bros get excited that Claude can propose exactly the same things that researchers did a few years ago
What is AI really capable of in bio? To separate hype from reality, we spent 3 months working firsthand with @AnthropicAI's internal research model to see if it could create an experimental scorpion antivenom. Introducing Citrini Therapeutics. citriniresearch.com/p/citrin…
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It’s a 1-2 punch this month with a 2-parter for you! We highlight the latest from our team published in @ScienceMagazine! #MerckChemistry podcasts.apple.com/us/podcas…
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Never seen larping at this level before, and I've been to actual LARPs.
We built an 8000 sqft. high-throughput wet-lab in 30 days, to solve molecular discovery - starting with pesticides. Most teams in drug-discovery don’t receive target-organism verification until clinical trials. Pesticides allow us to rapidly validate our model in the target organism directly. With the help of our high-throughput lab, we were able to generate compounds that killed a $13 billion pest, the Fall Armyworm. We believe that the bitter lesson is coming for biology.
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Jackson Cahn retweeted
This was a rewarding collab. with the Alexanian lab at UNC and Abbvie on making ncAAs: pubs.acs.org/jacsat/article/…. Very surprised by the generality of the strategy, which allowed us to make many unusual ncAAs
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Jackson Cahn retweeted
A fantastic metabolic engineering paper that: creates & regenerates a ~new cofactor (NUDH) engineers several enzymes in a ~new CO2 fixation pathway to utilize NUDH achieves impressive growth rates using a CO2/methanol feedstock & produces several products! nature.com/articles/s41467-0…
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A corndog must be encased in a cornmeal-based batter.
What's the word/grammar hill you are absolutely dying on?
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Biochem ppl: yeah this has been happening for like last 10-15 years, this is like discovering a new frog, they’re out there and it’s not particularly useful info. Not significant. AI ppl: holy shit, this is the first domino to fall, bio is the next math/CS field. GG disease. Gene editing ppl: wtf why can’t we get any hype/press/investor love for even putting systems like this together and curing patients Patients: cool so when do I get a cure for my genetic dz I’m dying from where we know the pinpoint mutation causing it
Claude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR. We don’t yet understand what this system does, but only a handful of known systems share its features, and all of them are able to cut, copy, and paste DNA. Historically, the discovery of such programmable systems has helped revolutionize medicine. CRISPR, for instance, is now the foundation of genetic medicines. But it will take much more work to learn what this system does, and whether it can be put to similar use. Read more: anthropic.com/news/claude-di…
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Jackson Cahn retweeted
I think this preprint title reveals a lot about Anthropic's approach to science. Scientific paper titles basically never mention the tools used to make the discoveries they report. The focus is on what was discovered. For example: - "A Structure for Deoxyribose Nucleic Acid" (Watson & Crick) - "Streptomycin, a Substance Exhibiting Antibiotic Activity against Gram-Positive and Gram-Negative Bacteria" (Waksman) - "A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity" (Doudna & Charpentier) - "Design of a Novel Globular Protein Fold with Atomic-Level Accuracy" (Baker) In each of these, the discovery / key deliverable is front and center. The machines, methods, and people used to make that discovery do not get mentioned because they're not the point. The discovery is what matters. Yet, here, Anthropic chose to title their preprint "Autonomous AI agents discover reverse transcriptases with tandem repeat arrays." That's not a scientific paper title: that is a headline. It puts the discovery secondary to the fact that "Autonomous AI agents" made it. If they were serious about putting science first, the fact that AI agents found a new enzyme would be no more important than if Taylor Swift did. This choice gives the game away. Though this is dressed-up as a scientific paper, it is not. It is a press release.
Claude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR. We don’t yet understand what this system does, but only a handful of known systems share its features, and all of them are able to cut, copy, and paste DNA. Historically, the discovery of such programmable systems has helped revolutionize medicine. CRISPR, for instance, is now the foundation of genetic medicines. But it will take much more work to learn what this system does, and whether it can be put to similar use. Read more: anthropic.com/news/claude-di…
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Sorry, but "I found an interesting looking gene, but I have no idea what it does" was a daily occurrence in my postdoc. I had a spreadsheet with hundreds of them. It's the figuring out that constitutes actually doing science.
Claude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR. We don’t yet understand what this system does, but only a handful of known systems share its features, and all of them are able to cut, copy, and paste DNA. Historically, the discovery of such programmable systems has helped revolutionize medicine. CRISPR, for instance, is now the foundation of genetic medicines. But it will take much more work to learn what this system does, and whether it can be put to similar use. Read more: anthropic.com/news/claude-di…
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Jackson Cahn retweeted
Look what #directedevolution can get #enzymes to do! Many congratulations to @ZiqiLi0513 for wrangling a new-to-nature enzyme for synthesis of #antibiotics for #tuberculosis treatment. Thanks to the @gatesfoundation for supporting this effort!
Appearing today in Nature, rdcu.be/sG2szzztqz5a we report the engineering of protoglobin nitrene transferases for the synthesis of chiral oxazolidinones. It’s been ~1300 days since my first glance at this project. A long but joyful journey!
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This is simultaneously deranged and brilliant
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Holy shit! The title DOESN’T do this justice it should read: “Susan Collins took Bribes; Trump FBI covered it up” -Scott Reed (of the Collins super PAC) raised money from a government contractor illegally via a shell company in exchange for offering government contracts. -He assured the contractor that Collins was aware of who the donation was from. -Kao (the contractors CEO) told the entire scheme to the US attorneys office hoping for leniency. -He provided a ***50-page document*** of details, including emails. -In document he named other GOP staffers and members of Congress who he had bribed via this donation scheme. -Trump had the FBI and US attorneys office drop the investigation.
New: In late 2024, FBI investigators had enough evidence to launch a sweeping bribery probe that could ensnare top lawmakers, including Sen. Susan Collins. Then Trump was reelected and eviscerated the FBI and DOJ teams handling public corruption probes. propub.li/4yLLwaF
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New: In late 2024, FBI investigators had enough evidence to launch a sweeping bribery probe that could ensnare top lawmakers, including Sen. Susan Collins. Then Trump was reelected and eviscerated the FBI and DOJ teams handling public corruption probes. propub.li/4yLLwaF
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