@jlduan

知君仙骨无寒暑，千载相逢犹旦暮。

instagram.com/jlduan
Joined June 2009
  • Tweets1.7K
  • Following2.7K
  • Followers147
744Media
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Jun Wu Lab@leo_jwu17 Mar 2021
We are excited to share our work on human blastoids as a model of pre- and peri-implantation human development (@leo_jwu, @hon_lab, @leqianyu, @Yyyyyy1005，@jlduan). Article: dx.doi.org/10.1038/s41586-02… News and Views: doi.org/10.1038/d41586-021-0… (1/10)
Scientists flock to DeepSeek: how they’re using the blockbuster AI model nature.com/articles/d41586-0…

Scientists flock to DeepSeek: how they’re using the blockbuster AI model

Nature - Researchers are testing how well the open model can perform scientific tasks — in topics from mathematics to cognitive neuroscience.

nature.com
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A community effort to optimize sequence-based deep learning models of gene regulation go.nature.com/3NnblYZ
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FDA new drug approvals in Q3 2024 tinyurl.com/4axj5wbz Several of the products approved in the the last quarter are expected to become blockbusters, including Cobenfy for schizophrenia, Kisunla for Alzheimer disease and Ebglysss for atopic dermatitis
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Epigenome editing is transforming biological sciences and medicine. We're grateful for the opportunity to publish this review of the field in @NatureBiotech. Check it out here: rdcu.be/dPjsJ
Nature Biotechnology
@NatureBiotech29 Jul 2024
Epigenome editing technologies for discovery and medicine go.nature.com/4cXw54M
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dana_peer@dana_peer20 Apr 2023
Excited to share our pre-print, spearheaded by @DoronTheViking (who did a phenomenal job, great fun to have grad students come up with the best ideas) providing a way to integrate scRNA-seq and spatial transcriptomics that fully utilizes spatial context biorxiv.org/cgi/content/shor…
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Zinc finger design is facilitated with a deep-learning model go.nature.com/3HBtUH5

A universal deep-learning model for zinc finger design enables transcription factor reprogramming

Nature Biotechnology - Zinc finger design is facilitated with a deep-learning model.

nature.com
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Data sharing in the age of deep learning How can we protect personal information and the integrity of artificial intelligence models when sharing data? go.nature.com/43ehqho
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Excited to share our TRACERx nature publication on circulating tumor DNA (#ctDNA, #MRD) detection in resectable lung cancer led by @AbboshChris, @Afrankell, @juditkisistok, Thomas Harrison, Aaron Garnett, @nbirkbak and @NickyMcGranahan 👇👇👇 Tweetorial🧵 nature.com/articles/s41586-0…
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Thrilled to share our new method, Nano-tRNAseq, a @nanopore direct #RNA sequencing approach that simultaneously quantifies tRNA abundances and modifications. If you’re interested in sequencing other small RNA types with nanopore, this method might interest you 1/ 🧵 – at Barcelona, Spain
Nature Biotechnology
@NatureBiotech6 Apr 2023
Quantitative analysis of tRNA abundance and modifications by nanopore RNA sequencing go.nature.com/3ZH3eu8
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A relay velocity model infers cell-dependent RNA velocity go.nature.com/3GaKgFa
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Rahul Satija@satijalab29 Mar 2023
We are excited to introduce Phospho-seq, our approach for profiling intracellular protein and cell signaling dynamics alongside additional molecular modalities in single cells! Check out @JBlairSci's preprint at biorxiv.org/content/10.1101/…

Phospho-seq: Integrated, multi-modal profiling of intracellular protein dynamics in single cells

Cell signaling plays a critical role in regulating cellular behavior and fate. While multimodal single-cell sequencing technologies are rapidly advancing, scalable and flexible profiling of cell...

biorxiv.org
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Coon Lab@Coon_Labs23 Mar 2023
Replying to @TheCoxLab
@TheCoxLab and @Coon_Labs scientists succeeded in developing a new method to generate a more detailed #proteome than ever before, providing insights into how #GeneticVariants and #SpliceVariants in humans impact the proteome. Published in @NatureBiotech nature.com/articles/s41587-0…
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A study in @NatMetabolism demonstrates that loss of PCYT2-synthesized phosphatidylethanolamines in muscle impairs sarcolemmal lipid bilayer stability and mitochondrial homeostasis, leading to muscle degeneration and premature ageing in mice. 🔒 go.nature.com/3JEyvHY
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Strife at eLife: inside a journal’s quest to upend science publishing nature.com/articles/d41586-0…
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Unveiled today at @nvidia's GTC- significant expansion of our #BioNemo cloud service for LLMs and Generative AI for Life Sciences R&D. nvidianews.nvidia.com/news/n… Honored to work with so many brilliant individuals and teams across Nvidia to build these technologies.

NVIDIA Unveils Large Language Models and Generative AI Service to Advance Life Sciences R&D

NVIDIA today announced an expanded set of generative AI cloud services for customizing AI foundation models to accelerate the creation of new proteins and therapeutics, as well as research in the...

nvidianews.nvidia.com
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Inheritance of epigenetic DNA marks studied in new mouse model nature.com/articles/d41586-0…
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New content online: High-throughput manufacturing of epitaxial membranes from a single wafer by 2D materials-based layer transfer process dlvr.it/SlC38k
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Jialei Duan retweeted
Rahul Satija@satijalab14 Mar 2023
Two new preprints for performing differential expression across conditions in scRNA-seq data, *without* having to call clusters first: 1. LEMUR (from @const_ae @wolfgangkhuber): biorxiv.org/content/10.1101/… 2. miloDE (from @Alsu_Troost @MarioniLab): biorxiv.org/content/10.1101/…
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