Jenny Luppino, PhD (@jloops22) header
Jenny Luppino, PhD (@jloops22) profile picture

Jenny Luppino, PhD

@jloops22

Post-doc in the @TjianDarzacq lab, UC Berkeley. Previously a grad student with @ericjoycelab at Penn. Obsessed with chromosomes.

 Berkeley, CA
Joined May 2016
  • Tweets119
  • Following185
  • Followers161
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Photo by Jenny Luppino, PhD (@jloops22)Photo by Jenny Luppino, PhD (@jloops22)
New preprint alert! 🔔🔔🔔 Check out the tweetorial below and BioRxiv for the full manuscript!
Eric Joyce (@ericjoycelab) profile pictureEric Joyce@ericjoycelab20 Apr 2022
What happens to chromatin folding and transcription when two opposing cohesin regulators, NIPBL and WAPL, are depleted? Please check out our new preprint led by @jloops22 where this simple question yielded some very surprising results 🧵 biorxiv.org/content/10.1101/…
NIPBL and WAPL balance cohesin activity to regulate chromatin folding and gene expression

NIPBL and WAPL balance cohesin activity to regulate chromatin folding and gene expression

The relationship between cohesin-mediated chromatin looping and gene expression remains unclear. We investigated the roles of NIPBL and WAPL, two regulators of cohesin activity, in chromatin folding...

biorxiv.org
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Siewert Hugelier (@SHugelier) profile picture
Siewert Hugelier@SHugelier10 Sep 2024
Interested in a fully automatic analysis pipeline to quantify and classify your 2D and 3D Single-Molecule Localization Microscopy (SMLM) data in an unbiased way? Have a look at our latest work covering ECLiPSE, developed in the @Melike_Lak lab! doi.org/10.1038/s41592-024-0… 1/11
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The first Rosin lab paper it out now in @PLOSGenetics! Feat. postbacs Clio Hockens and Tricia Wang @probpipetting and wrapping up my work with @The_Lei_Team Chr. seg. during spermatogenesis occurs through a center-kinetic mechanism in holocentric moths rb.gy/ts9u64
Image from Leah Rosin (Lee-ah Rose-in) (@scienceLeah)
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Oded Rechavi (@OdedRechavi) profile picture
Oded Rechavi
@OdedRechavi28 May 2024
Phase separation
Nature is Amazing ☘️ (@AMAZlNGNATURE) profile pictureNature is Amazing ☘️
@AMAZlNGNATURE26 May 2024
What do you suppose they are talking about?
Image from Nature is Amazing ☘️ (@AMAZlNGNATURE)
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Dr. Sedona Murphy (@SedonaMurphy) profile picture
Dr. Sedona Murphy@SedonaMurphy24 Apr 2024
Seeking someone looking for a two-year postbac position to get my group up and running at Yale University! We will be utilizing chromatin tracing and other multiplexed imaging approaches to study the relationship between 3D genome organization and epigenetic memory in embryos!
Image from Dr. Sedona Murphy (@SedonaMurphy)
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Sangya Agarwal (@SangyaAgarwal) profile picture
Sangya Agarwal@SangyaAgarwal22 Mar 2024
Thank you @scientia_social for highlighting our work in this outreach article! @carlhjune #CARTcelltherapy
Scientia (@scientia_social) profile pictureScientia
@scientia_social22 Mar 2024
Discover Dr. Sangya Agarwal's strides in enhancing blood cancer treatment! doi.org/10.1016/j.immuni.202… Read more: scientia.global/dr-sangya-ag… @SangyaAgarwal @PennMedicine #CancerResearch #MedicalInnovation
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Jonathan P. Karr (@jonathanpkarr) profile picture
Jonathan P. Karr@jonathanpkarr2 Jan 2024
So this happened while I was vacationing. Jack and I at the @TjianDarzacq lab combined SM imaging with domain chopping (à la classical biochemistry) to determine which bits of p300 make it bind to chromatin in living cells. Turns out it's all about TF binding.
Molecular Cell (@MolecularCell) profile pictureMolecular Cell@MolecularCell29 Dec 2023
Online Now: p300 is an obligate integrator of combinatorial transcription factor inputs dlvr.it/T0l1pK
Image from Molecular Cell (@MolecularCell)
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Steph Sansbury (@stephsansbury) profile picture
Steph Sansbury@stephsansbury29 Sep 2023
My brilliant, creative, unstoppable friend did very cool work toward even more powerful CART cell therapies:
Sangya Agarwal (@SangyaAgarwal) profile pictureSangya Agarwal@SangyaAgarwal29 Sep 2023
Excited to share my Ph.D. work in @carlhjune lab showing uninhibited CD28 co-stimulation via CTLA4 disruption invigorates dysfunctional CART cells doi.org/10.1016/j.immuni.202…
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Sangya Agarwal (@SangyaAgarwal) profile picture
Sangya Agarwal@SangyaAgarwal29 Sep 2023
Excited to share my Ph.D. work in @carlhjune lab showing uninhibited CD28 co-stimulation via CTLA4 disruption invigorates dysfunctional CART cells doi.org/10.1016/j.immuni.202…
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A major limitation for #genetherapy is delivering large cargo with #AAV. We know that AAV vector DNA concatenates into large episomes in the nucleus, but how does this happen? Led by @annacmaurer we built a system to watch AAV vector genomes in live cells 1/ 🧵
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Jane Skok (@jane_skok) profile picture
Jane Skok@jane_skok16 Sep 2023
Excited to announce that registration is now open for the Fourth Annual Meeting on Advances in Nuclear Topology and 3D Chromatin Architecture in Cancer. As always we have a fantastic lineup of speakers!
Image from Jane Skok (@jane_skok)
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Excited to see our latest collaboration with @DrinnenbergLab and @leonidmirny lab looking at interphase genome organization in Bombyx online now!
The Lei Team (@The_Lei_Team) profile pictureThe Lei Team@The_Lei_Team18 Sep 2023
Freshly posted on bioRxiv, our @ScienceLeah collaborative work with the Drinnenberg and Mirny labs characterizes unique compartment S (Secluded) in the holocentric silkworm moth biorxiv.org/content/10.1101/…
Unique territorial and sub-chromosomal organization revealed in the holocentric moth Bombyx mori

Unique territorial and sub-chromosomal organization revealed in the holocentric moth Bombyx mori

The hallmarks of chromosome organization in multicellular eukaryotes are chromosome territories (CT), chromatin compartments, and different types of domains, including topologically associated...

biorxiv.org
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How is chromatin binding of the Type 2 nuclear receptor (T2NR) network regulated? New work out now on @biorxivpreprint led by @DahalLiza w/ @tgwgraham Gina Dailey Alec Heckert @XDarzacq biorxiv.org/content/10.1101/…
Image from Tjian + Darzacq Group (@TjianDarzacq)
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The Rosin Lab is still hiring! We are looking for motivated postbacs and postdocs (fully funded!) to study chromosome dynamics in the germline and soma in insect and mouse models. Our newest recruit arrived in June and she is ready to meet her new labmates ❤️
Image from Leah Rosin (Lee-ah Rose-in) (@scienceLeah)
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Steph Sansbury (@stephsansbury) profile picture
Steph Sansbury@stephsansbury14 Jul 2023
I'm really excited to present work from @ophirshalem’s group with my outstanding co-first author Yevgeniy Serebrenik @YSereb to tag and manipulate proteins at scale, which we use to study the #proteome and #proteostasis biorxiv.org/content/10.1101/…
Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded...

Pooled tagging and hydrophobic targeting of endogenous proteins for unbiased mapping of unfolded...

System-level understanding of proteome organization and function requires methods for direct visualization and manipulation of proteins at scale. We developed an approach enabled by high-throughput...

biorxiv.org
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Put this on your "to read" list! Impressive feat led by @dsjpark to screen the druggable genome for regulators of chromatin organization
Daniel S. Park (@dsjpark) profile pictureDaniel S. Park@dsjpark13 Jul 2023
Excited to share our updated HiDRO paper in @nature rdcu.be/dgGge! We used HiDRO to screen for druggable regulators of 3D genome folding. We further characterized a novel noncanonical function of GSK3A in regulating cohesin. Brief summary highlighting what’s new: 1/
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Eric Joyce (@ericjoycelab) profile picture
Eric Joyce@ericjoycelab12 Jul 2023
Our HiDRO paper is now published in @Nature nature.com/articles/s41586-0… Since the preprint, we made a few key additions worth checking out. Thanks to reviewers for their helpful suggestions! Original tweetorial posted below:
Eric Joyce (@ericjoycelab) profile pictureEric Joyce@ericjoycelab11 Apr 2022
(1/n) We are excited to share our new preprint: doi.org/10.1101/2022.04.08.4… Led by @dsjpark we first describe our development of HiDRO for high-throughput DNA or RNA labeling with optimized Oligopaints.
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