@joonomics

Scientist working on autism genetics. Associate Prof at Korea University. family ๐Ÿ‘จโ€๐Ÿ‘ฉโ€๐Ÿ‘งโ€๐Ÿ‘ฆ, swimming ๐ŸŠ๐Ÿผโ€โ™‚๏ธ but hiking too โ›ฐ

 Seoul, Republic of Korea
joonanlab.github.io/
Joined January 2013
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๋ฉ€ํ‹ฐ์—์ด์ „ํŠธ ํ•˜๋„ค์‹ฑ๊ณผ ๋ฃจํ”„๋ฅผ ๊ตฌ์„ฑ ์ค‘. ์•„์นจ ์ ํ˜ธ ์‹œ๊ฐ„์— ์ƒ์กด(?) ํ™•์ธ. ์ž‘์—… ์ค‘์ด์—ˆ๋˜ ๋‘๋ฃจ๋Š” ์ ํ˜ธ์— ์ฐธ์—ฌํ•˜์ง€ ๋ชปํ•จ. ๊ฐ ์—์ด์ „ํŠธ๋Š” tmux ์„ธ์…˜์— ๋ถ™์—ฌ์„œ ํ™œ์„ฑํ™” ํ•ด๋‘ . ์ž‘์—…์ด ๋“ค์–ด์˜ด์— ๋”ฐ๋ผ 80์—ฌ๊ฐœ์˜ ๋ฃจํ”„ (์‚ฌ์ „ ์ง€์ •)์— ๋”ฐ๋ผ ์›€์ง์ž„.
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๋ฃจํ”„ ํ•˜๋‚˜์˜ ์˜ˆ์‹œ ์•„์นจ ๋ณด๊ณ  ์‹œ, ์—ฐ๊ตฌ์‹ค ๋ฉค๋ฒ„๋“ค์˜ ์ž‘์„ฑ ์ค‘์ธ ๋…ผ๋ฌธ๋“ค๊ณผ ์—ฐ๊ตฌ ์ฃผ์ œ๋ฅผ ๊ณ ๋ คํ•ด์„œ ์ˆ˜์ง‘ํ•œ ๋…ผ๋ฌธ๋“ค์„ ์š”์•ฝํ•ด์„œ ์ถ”์ฒœํ•จ. ๋ฉค๋ฒ„๋ณ„ ์ž๋ฃŒ ์—ฐ๊ฒฐ์€ ๋ณด๋‹ค ์ •๊ตํ•˜๊ฒŒ ํ•ด์•ผํ•  ํ•„์š”๊ฐ€ ์žˆ์Œ (๋ช‡๋ช‡ ์˜คํƒ์ด..)
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AWS ํด๋ผ์šฐ๋“œ ๊ธฐ๋ฐ˜ ๋ฒผ๋ฆฌ๋Š” LLM-Wiki๋ฅผ ํ˜‘์—…์— ๊ทน๋Œ€ํ™” ํ•˜๋Š” ๋ฐฉ์‹์ธ๋ฐ์š”, ๊ทธ ์ „์— ๊ฐœ๋ณ„ ์—ฐ๊ตฌ์ž๋“ค์ด ๋กœ์ปฌ์—์„œ LLM-Wiki๋ฅผ ์—ฐ๊ตฌ์— ํ™œ์šฉํ•˜๋Š” ๋ฐฉ์‹์„ ์ผ์Šต๋‹ˆ๋‹ค. ๋ฐ˜๋…„ ๋„˜๊ฒŒ ์จ๋ดค๋Š”๋ฐ, ๋งค์šฐ ์œ ์šฉํ•ฉ๋‹ˆ๋‹ค. ๋ฐฉ์‹์€ ์ด๊ณณ์— ์ •๋ฆฌํ•ด๋‘์—ˆ์Šต๋‹ˆ๋‹ค chaek.org/books/llm-wiki-forโ€ฆ
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LLM-Wiki๋ฅผ ํด๋ผ์šฐ๋“œ์—์„œ ์‚ฌ์šฉํ•˜๋Š” ๋ฐฉ๋ฒ•. ์—ฐ๊ตฌ์‹ค์—์„œ ์“ฐ๋˜ ๋…ผ๋ฌธ ์œ„ํ‚ค ์‹œ์Šคํ…œ "๋ฒผ๋ฆฌ"๋ฅผ ๊นƒํ—™์— ์˜ฌ๋ ค๋‘์—ˆ์Šต๋‹ˆ๋‹ค. ๋‹ค๋ฅธ ์—ฐ๊ตฌ์‹ค์—์„œ๋„ ๊ด€์‹ฌ์ด ์žˆ์„๊ฒƒ ๊ฐ™์•„ ๊ณต๊ฐœํ•ฉ๋‹ˆ๋‹ค. github.com/joonan-lab/byeoriโ€ฆ
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ํ˜„์žฌ๋Š” JEV๊ฐ€ ๊ทธ ์—ญํ• ์„ ํ•˜๊ณ  ๋งค์šฐ ์ €๋ ดํ•ฉ๋‹ˆ๋‹ค๋งŒ, ์ด๊ฒŒ ์•„์ฃผ ์ข‹์€ ์†”๋ฃจ์…˜์ธ์ง€๋Š” ๋ชจ๋ฅด๊ฒ ์Šต๋‹ˆ๋‹ค. ๊ทธ๊ฒƒ๊ณผ ๋ณ„๊ฐœ๋กœ, ์šด์˜์ž์ฒด์— ๋Œ€ํ•œ ๋น„์šฉ์ด๋‚˜ ์†๋„๋Š” AWS ์—์„œ ๋งค์šฐ ํƒ์›”ํ•ฉ๋‹ˆ๋‹ค.
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๋ฉค๋ฒ„๋“ค์ด ์ ‘๊ทผํ•ด์„œ ์“ฐ๋Š” ๋ฐฉ์‹๋„ ํŽธ๋ฆฌํ•˜๊ณ , ๋ฉค๋ฒ„๋“ค์—๊ฒŒ ๋ฒผ๋ฆฌ ์ ‘๊ทผ์„ ์œ„ํ•œ ๊ฐœ๋ณ„ IAM๋งŒ ์ œ๊ณตํ•˜๋ฉด ๋˜๊ธฐ ๋•Œ๋ฌธ์—, ์ ‘๊ทผํ•˜๊ณ  ๊ด€๋ฆฌํ•˜๋Š”๊ฒƒ๋„ ์‰ฝ์Šต๋‹ˆ๋‹ค. ์จ ๋ณด์‹œ๊ณ  ๋ง‰ํžˆ๋Š” ๊ณณ์€ GitHub issue๋กœ ๋‚จ๊ฒจ ์ฃผ์‹œ๋ฉด ๋ฉ๋‹ˆ๋‹ค.
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๋ญ”๊ฐ€๋ฅผ ๊ฐœ๋ฐœ์ค‘์ธ๋ฐ, chatgpt๊ฐ€ ์ค€ ๊ฒฐ๊ณผ์— ๋งŒ์กฑํ•œ๋‹ค๊ณ  ํ–ˆ๋”๋‹ˆ, ์ด๋ ‡๊ฒŒ ๋ฐ˜์‘ํ•จ. ๋ญ์•ผ ์ด๊ฑฐ? @thsottiaux
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Hi @thsottiaux โ€” Iโ€™m trying to apply for GPT-Rosalind access for our genomics research at my University. My OpenAI API organization is verified , but the Rosalind application says it canโ€™t load any organizations from my account. Any idea how I can resolve this? Thanks!
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Can a virtual cell tell us where to look for autism genes? In our new preprint, NOCAP-AI, we trained a single-cell foundation model on 3.6 million cells from human brain organoids to learn how genetic perturbations affect developing brain cells.
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Genetic evidence supported two distinct developmental programs, involving fetal neurons and early radial glia. The framework prioritized 343 candidates beyond established autism and neurodevelopmental disorder gene sets.
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We see this as an early demonstration that virtual-cell models can contribute to disease gene discovery, with predictions learned from organoid experiments evaluated against human genomes. Our preprint is now on bioRxiv: biorxiv.org/content/10.64898โ€ฆ
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