Pathologist #PathKeys

Posts = my own opinion
Joined November 2022
Dx? breast HER2 #Pathkeys
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4
395
馃КHER2 overexpression in up to ~90% of cases 鈽笍MRI: enhancement and thickening of the nipple-areolar complex, with retroareolar or segmental non-mass enhancement.
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Image (pathology): Sharma A, et al. Cureus 2026;18:e110432 (CC BY 4.0) Image (MRI): Mariano L, et al. Front Oncol 2025;14:1497506 (CC BY 4.0) Ref: Choridah L, et al. J Med Case Rep 2020;14:119 Ref: Cantisani C, et al. Diagnostics 2025;15:1898
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Dx? soft tissue HE #Pathkeys 2025-1p-5 (etc)
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4
21
1,137
馃Кt(X;18) SS18::SSX1/2/4 fusion 鈽笍Well-circumscribed intramuscular mass with heterogeneous enhancement on contrast-enhanced MRI (representative case)
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150
Image (pathology, MRI): Choi JH. Int J Mol Sci 2026;27:4125 (CC BY 4.0) Ref: Choi JH. Int J Mol Sci 2026;27:4125
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Dx? breast ER #Pathkeys 2013-2a-11
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914
鈽笍Round high-density mass on mammography; circumscribed hypoechoic mass with blood flow on US (this case)
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Image (pathology, US): Lin X, et al. Surg Case Rep 2020;6:143 (CC BY 4.0) Ref: Lin X, et al. Surg Case Rep 2020;6:143 Chiang S, et al. Cancer Res 2016;76:7118-7129
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Dx? thyroid HE #Pathkeys 2025-2a-15 (etc)
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776
猸昅edullary thyroid carcinoma 馃敩Nests of monotonous polygonal to plasmacytoid cells in a hyalinized stroma 馃КRET or RAS driver mutations, mutually exclusive in sporadic cases; germline RET in MEN2A/2B
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166
Image (pathology): Rossi ED, et al. Virchows Arch 2026;489:427-439 (CC BY 4.0) Ref: Rossi ED, et al. Virchows Arch 2026;489:427-439
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Dx? prostate HE #Pathkeys 2024-2c-7 (etc)
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933
猸旸uctal adenocarcinoma of the prostate 馃敩Papillary and cribriform glands lined by tall columnar pseudostratified epithelium 馃И尾-catenin+ (focal nuclear) 馃КAPC mutation with loss of heterozygosity (this case)
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Image (pathology): Umeda K, et al. Diagn Pathol 2020;15:102 (CC BY 4.0) Ref: Umeda K, et al. Diagn Pathol 2020;15:102
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Dx? lung HE #Pathkeys 2011-2a-20 (etc)
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15
1,098
猸旼ranulomatosis with polyangiitis (GPA) 馃敩Necrotizing granulomatous inflammation with geographic necrosis, multinucleated giant cells and small-vessel vasculitis
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165
Image : Wang A, et al. Cureus 2026;18:e101192 (CC BY 4.0) Ref: Wang A, et al. Cureus 2026;18:e101192
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