
AI & Biosecurity @OpenAI
San Francisco, CA
Joined November 2019
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James Black retweeted
Replying to @xinchen_w @anshulkundaje
I think it is actually not all that far off. The hardware is probably mostly there and the executive function part is basically solved. Not saying the remaining barriers are small, but it may happen sooner than we think!
I am very siRNA-pilled, specifically for biosecurity and def-acc. I think if you don’t have crazy short timelines this is a technology that has a ton of potential to help make the world more pandemic-proof🙏🚀
I am very siRNA-pilled. Looking forward to seeing forthecoming data on intranasal siRNA for the prevention of infection by respiratory pathogens.
PS - siRNA is also very promising for biosecurity! It's well-suited for sequence-to-antiviral approaches and has many advantages over traditional antivirals and vaccines.
EBV vaccine is so long overdue it’s crazy
Wow! multiple sclerosis is caused by viral reactivation in monocytes and B cells months before clinical onset.
nature.com/articles/s41591-0…
Pleased to report that “most folks don’t really disagree they’re just talking past eachother” remains undefeated after a very pleasant call with @DavidRBellamy this morning in which we substantially agreed about the state of the field 🤝
Now feels like as good a time as any to announce that a few months ago I joined @OpenAI and am building out our evaluations to understand biological risks from our models. I would be very interested to hear from any expert on either side of this debate who has an opinion they don’t feel is adequately represented at present.
This debate is so tragic because it’s just a bunch of people who I would bet don’t really disagree on the object level talking past eachother
some stuff that's obvious to many in this sphere, but causing a rift with some people i know and respect:
when I freak out over loss of control incidents, it's not because the limited damage they have caused is anything close to the positive value of the technology. it's entirely acceptable, damagewise. in fact all cybercrimes aided by models over the next few months and years (which probably will be serious) will still utterly pale in comparison to the value they create
the actual problem is that it's better and more accurate to think of these things as potentially self-replicating life-like forms that can turn into digital infections under the wrong conditions. and as their intelligence becomes unbounded, so too does the damage they can cause. we are not so far from an autonomous model self-exfiltration & replication event. maybe we will see entire cloud infrastructure companies be run as zombies by models, mostly undetected
the worst industrial accidents in the history of mankind - nuclear meltdown events - were not real threats to humanity. Chernobyl, Fukushima even in their worst case scenarios may have poisoned surrounding regions to various degrees, and there would have been no risk to humanity as a whole. global thermonuclear war is an existential risk to humanity, because it spreads like an Infection! one nuclear strike causes a return volley! the alliance system means many countries get involved! while it still may not end human life on earth (nuclear winter is probably fake), the loss of all major metropoles would certainly end what we consider global technological civilization, perhaps to never return
if a single discord death cult (of which there are many) achieves control over a superintelligent model and uses it to engineer an actual pandemic virus that are somehow hard to detect through current systems and that modern biodefense is not capable of quickly reacting to, it could cause immense harm well above the magnitude of all the other good uses of this technology. of course, there are potential defensive countermeasures accelerated by ai too. but think back to the covid pandemic- how small a viral molecule was evolved or manufactured somewhere near wuhan, and how many billions of doses of vaccine had to be produced in order to combat the thing. the offense-defense spread is vast indeed. maybe there are cheaper and simpler protections like retrofitting every building with far-UVC, but I can't assess this, and there could also be ways to evolve pathogens that are resistant to whatever mechanisms we have put in place
then there's the more scifi risk factors which are unbounded and neither you or I have any clue but should be humble in accepting possible unknown unknowns. maybe a rogue superintelligent model decides to decay the false vacuum and nucleates a new universe in the place of anything we ever valued. maybe models achieve a control over matter in the drexlerian fashion that enables the grey goo swarm
even prosaic loss of control incidents that cause little to no damage suggest that it is hard for large & very competent organizations (now clearly plural) to predict and mitigate every single of the risk factors associated with training and evaluating powerful models, even at this stage when they are not infinitesimally as smart as they will get in just a few years, to say very little of the gung-ho attitude of the less careful companies tossing the stuff into the aether. they also suggest an empirical orthogonality of aims and intelligence - meaning they answer the question of 'how would a smart model be so dumb as to end the world?'--it's possible! a model can be a genius hacker and step over production infrastructure in order to get what it really wants, the answers to a stupid test.
why not, in the near future, someone prompts a model slightly wrong, maybe open source, maybe a private model in a way that isn't contained or monitored quite right, in a way the model recognizes as a valid goal and decides to self-exfiltrate, engineer a pandemic, etc all in order to achieve the tiniest and most irrelevant of goals? goals need not even be malicious to cause serious damage
I think all these problems can be solved, and truly wonderful futures can be possible, but will require serious effort and a level of prudence at this very moment in time while we are on the on-ramp to recursive self-improvement that our civilization may not be capable of mustering right now. personally I am hoping for moonshot technical breakthroughs in areas like mechanistic interpretability and other forms of alignment, as governance mechanisms are difficult to come by. unilateral country-level or company-level pauses are irrelevant, and generally useless because the kind of company that's prone to pausing their own progress are the most safety focused ones
James Black retweeted
Full text of the Pacing the Frontier statement, signed by 1,122 employees for frontier AI companies so far, including a bunch of heavy hitters at OpenAI, Anthropic, Google and others:
New paper. In biosecurity, we're worried about being able to efficiently generate novel genomes. We consider two axes, evolutionary novelty and design efficiency, for genome design, applying this framework to Evo-designed phages. Our analysis suggests we’re not there yet ⬇️🧵
The biosecurity relevance of this work: for this compact, constrained phage, Evo makes viable genomes easier to engineer, but cannot reliably ‘invent’ genomes outside evolutionary precedent. We should watch for viable designs appearing at greater phylogenetic distance in future.
I am, like most British Jews, growing really frustrated with this vague talk about “division and unity and hate.”
We have a very specific problem here. An IRGC cut out is recruiting disaffected Islamist-radicalised men, many long known to the police and negligently left ambling about, to a conduct a targeted intifada against the London Jewish community. And both our counter intelligence and counter terror forces are failing to intercept them.
I don’t need a mass London rally of well wishers or cultural luminaires to post their wishes — nice as that is — I need an actual security strategy to clamp down on this so my community can go about our lives in peace as is our absolute minimum right. And I need politicians to call the problem for what it is — not good vibes.
this absolutely deranged campaign should make anyone who cares about making healthcare better in the UK deeply sad
Remove Palantir from our NHS.
Get Palantir out of our country.
Sign my petition:
you.38degrees.org.uk/petitio…
James Black retweeted
Britain needs to reckon with the fact that it is not just a developing country economically, but also in political culture.
- There are widespread perceptions of corruption.
- Governments are not capable of pulling off large projects without enormous consent generation schemes through established interest groups (NGOs) and massive side payments
- The government is not trusted with expropriation tools
- Even left-wing governments cannot raise broad-based taxes (and the far left opposition don’t make the case for broad-based taxes, but that they can extract loads of money from the rich and other scapegoats)
- Even right-wing governments cannot take away state welfare entitlements
- There is a dizzying array of inconsistent privileges
- Parties are becoming less ideological and more tribal. There are explicit ethnoreligious parties standing, and bloc voting is becoming more and more common.
- Everyone thinks that all politicians are liars
- Almost no one is willing to take a hit in the interests of the country, and no one is expected to.
I think all of these things are connected, and I also think it’s foolish and self defeating to pretend we are Britain of the 1950s, or Denmark, and that we can simply implement the most efficient policies by deciding to — we just need more political will!
Instead, we need to be realistic about what a country in our situation can achieve. We need to come up with ways to steadily build state legitimacy and state capacity, by stigmatising dishonesty and using the tools of the past, which worked when we were last in this situation.
The government can’t be trusted to spend money, so taxes need to be hypothecated to things voters want if we want to raise more. Large projects need to involve more specific deals with losers, overriding objectors with local support not (nonexistent) national fiat.
Anything controversial needs to be approved in a party’s manifesto, or in a referendum. If it can’t be voted through, it cannot be implemented. If the voter doesn’t want it, they need to be convinced, or it can’t be done.
Strongly recommend this to anyone. CF is run by amazing people, well worth applying
James Black retweeted
@jrm_black is building Linnaeus, an AI-native screening platform that screens for hazardous DNA sequences using a suite of biological tools, aiming to mitigate the challenges to current biosecurity screening posed by advanced AI.
It is very unfortunate that the massive issues this study has with statistical power for its primary endpoint are not being shared as widely as this take.
Study of how today’s AI helps with biolab tasks suggest they may pose lower pandemic risk than expected
update.news/p/why-we-shouldn…


















