Professor of Biomedical Engineering and Cardiovascular Medicine. Systems biology to discover drugs for heart disease. my opinions. Fun: 🥾 🏊♀ 📷 🛶 🐕🦺
Virginia, USA
Joined September 2015
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Terrific paper by post-doc Alex Clark now out at @PLOSCompBiol. This tutorial enables students and biologists to simulate biological networks with our tool Netflux, no programming required! #sysbio journals.plos.org/ploscompbi…
Undergrads: come to @UVABME *this summer* for our @NSF-funded #REU in multi-scale bioengineering! engineering.virginia.edu/dep…
Way to go Malcolm on his @NSF Fellowship! Malcolm is helping lead the expansion of my cardiac systems biolog lab into immunology.
"I use a systems biology approach to uncover how the immune system contributes to heart disease, the leading cause of death worldwide." 2nd-yr grad student Malcolm O'Malley, advised by @jsauce7, received an NSF Graduate Student Fellowship for his work. Congratulations Malcolm!
Jeff Saucerman retweeted
@Luke_Dunaway, PhD, recently received an @American_Heart Career Development Award to study iron's role in chronic kidney disease. Luke is a postdoc in the Isakson Lab and member of our Cardiovascular Training Program. Congratulations!
Read more: cvrc.virginia.edu/luke-dunaw…
Thanks for featuring our drug discovery research! Original article @PNASNews here: pnas.org/doi/10.1073/pnas.24…
UVA researchers develop AI tool to advance modern healthcare wric.com/news/virginia-news/…
Thanks for featuring our latest paper @PNASNews! With our AI tool LogiRx, we discovered that the antidepressant Lexapro attenuates cardiomyocyte hypertrophy. Validated in cells, mice, and 2 patient observational cohorts.
The tool predicts who may benefit and how drugs work in the body. 29news.com/2025/03/18/new-ai…
Here's the paper: pnas.org/doi/10.1073/pnas.24…
Happy to share our paper, "Logic-based machine learning predicts how escitalopram (LexaPro) attenuates cardiomyocyte hypertrophy" in @PNASNews, with @tayloreggertsen with @JoshTravers89, @McKinseyLab, & @MattWolfMDPhD. Validated in cells, mice & patients. pnas.org/doi/10.1073/pnas.24…
Finally, we mined electronic health records in both the FDA and UVA Health System. We found a lower incidence of left ventricular hypertrophy in patients with depression on escitalopram compared to other SSRIs. Similar trends across male/female and those with anxiety. 5/n
Overall, we're looking forward to seeing how LogiRx and related mechanistic machine learning methods can predict what drugs to prioritize and discover the surprising pathways by which they work. Try LogiRx and adapt to your applications with our code! 6/6 github.com/saucermanlab/Egge…
Rep. Alexandria Ocasio-Cortez @AOC asks, "What expertise does (Elon) have… in biomedical engineering devices?" #BME @BMESociety @AIMBE
Trump's slashing of NIH indirects blocked for now in 22 states but not VA. Will the "peoples protector" Attorney General @JasonMiyaresVA stand up for Virginia researchers and doctors and their work to cure cancer, heart disease, diabetes, and more? – at Virginia, USA
In Virginia:
NIH Awards Funding: $664 M
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working together for the health of all Virginians
I invite you to the 3rd Netflux and Logic-based Network Biology Virtual Conference next week on January 8. Tutorials with user-friendly network modeling tools, talks by trainees, and a keynote by Reka Albert. 🧪 Info and free registration at: buff.ly/4fH3QYw
