Professor of Surgery & Oncology Breast cancer surgeon Thinking outside the box, Curiosity, Creativity & Compassion-essential.
London, England
Joined February 2009
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TARGIT-IORT during lumpectomy is better than post-op whole breast radiotherapy:
= equally effective for #breastcancer
⬇︎pain, travel, cost
⬇︎deaths (heart/lung/other cancers)
⬆quality of life
⬆survival for grade 1 or 2 cancers
bmj.com/content/bmj/370/bmj.… nature.com/articles/s41416-0…
ALT Targeted intraoperative radiotherapy (TARGIT-IORT) is given immediately after breast cancer is removed by lumpectomy surgery, under the same anaesthetic. Image credit @bmj_latest
An important finding was that TARGIT-IORT reduced development of lung cancer in breast cancer survivors: 16-year rate was 7.2% with whole breast external beam radiotherapy vs 1.8% with targeted intraoperative radiotherapy discovery.ucl.ac.uk/id/eprin…
doi.org/10.3310/GJJV2820
Long term follow up of patients in randomised trials in the UK (eg TARGIT-A trial of intraoperative radiotherapy for breast cancer) is possible using direct patient contact and data from national registries (NIHR (HTA) funded) journalslibrary.nihr.ac.uk/h…
More: targit.org.uk
Long term follow up of patients in randomised trials in the UK (eg TARGIT-A trial of intraoperative radiotherapy for breast cancer) is possible using direct patient contact and data from national registries (NIHR (HTA) funded) journalslibrary.nihr.ac.uk/h…
More: targit.org.uk
Targeted intraoperative radiotherapy in breast cancer patients (>=70y): excellent long-term follow-up results in prospective TARGIT-E trial: high local control, overall survival, low late toxicities: fast, simple and given during lumpectomy surgery
link.springer.com/content/pd…
Prof Jayant Vaidya retweeted
Experts Urge Rethinking Restrictions on Menopausal MHT After Breast Cancer
The authors looked to address a lingering question in breast cancer care: can #HRT be safely administered to manage #menopause symptoms?
@jsvaidya @UCLResearch
#breastcancer
hubs.li/Q03M9D9f0
Menopausal Hormone Therapy for breast cancer patients: What is the current evidence?
journals.lww.com/menopausejo…
Experts call for change of heart on hormone replacement therapy after breast cancer ucl.ac.uk/news/2025/sep/expe…
Open Access UCL Research: The evolution of targeted intra operative radiotherapy in early breast cancer link.springer.com/article/10…
RCT evidence: better outcomes for mid- and low- recital cancer with robotic surgery (vs laparoscopic)
jamanetwork.com/journals/jam…
Prof Jayant Vaidya retweeted
16/ When you hear, "the CDC's Epidemic Intelligence Service class was cancelled and the officers fired" I hope this gives you a sense of what has been lost.
Not just the outbreaks that can't be investigated, the surge capacity gone, but our future public health leadership lost
Excellent outcomes from intraoperative radiotherapy (TARGIT-IORT) tumour bed boost with Intrabeam during lumpectomy + 3-week hypo-fractionated whole breast radiotherapy for higher risk breast cancer (46% node pos). No gr 3 toxicity and no local recurrence link.springer.com/article/10…
RCT evidence : 1 in 5 women with breast cancer have a cardiac event within a year of even "heart-sparing" IMRT onlinelibrary.wiley.com/doi/…
@NICEComms should preferentially recommend targeted intraoperative radiotherapy targit.org.uk effective, safer and reduces deaths
ALT DOI: 10.1002/ijc.35245 https://onlinelibrary.wiley.com/doi/10.1002/ijc.35245
Real world clinical outcomes from intraoperative radiotherapy (TARGIT-IORT) during lumpectomy for breast cancer in a a large cohort (814 patients) at a national cancer institute replicated breast cancer control and survival results of the TARGIT-A trial frontiersin.org/journals/onc…
Full adoption of TARGIT-IORT during lumpectomy for breast cancer in UK & Germany would avoid 5 & 6 million miles' travel, 170000 & 200000 woman-hrs, 1200 & 1500 tons of CO2 (forests of 100 & 125 hectares) per year, respectively bmjopen.bmj.com/content/6/5/…
link.springer.com/content/pd…
Full adoption of TARGIT-IORT during lumpectomy for breast cancer in UK would avoid 800 to 1000 deaths from other causes (cardiovascular, lung and other cancers) /year (⬆️ overall survival in grade 1 or 2) bmj.com/content/bmj/370/bmj.…
nature.com/articles/s41416-0…
frontiersin.org/articles/10.…
Ultimate hypofractionation: TARGIT-IORT during lumpectomy for breast cancer is effective, reduces non-breast-cancer deaths, improves overall survival in for grade 1 or 2 cancers, and would save 5 million miles of travel, & 1200 tonnes of CO2 in the UK/yr bmj.com/content/386/bmj-2023…
Prof Jayant Vaidya retweeted
New Research: Case report: IORT as an alternative treatment option for breast cancer patients with difficulty staying still frontiersin.org/articles/10.… #FrontiersIn #Oncology
UK patients with breast cancer perceive even 5-day post-op radiotherapy as being greatly disruptive. They prefer receiving TARGIT-IORT while they are asleep during surgery - it gives them the feeling of stamping out the cancer without conscious awareness bmjopen.bmj.com/content/14/8…
Prof Jayant Vaidya retweeted
Can you see why there is no good will left in the NHS. We do 12h shifts 7 days a week. Is it too much to ask for hot food on the weekends?
Prof Jayant Vaidya retweeted
An anecdote of an interaction with a patient that has stayed with me for 15 years.
When I was a fresh-faced 2nd year doctor in a GP practice, a young lady came for an appointment.
She couldn’t have been more than 5 years older than me.
The reason was ‘work stress’
A long 🧵