Translational science at @Regeneron. Tweets and views my own.
Brooklyn, NY
Joined September 2013
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Matthew Wipperman retweeted
One of the worst phenotypes among scientists is what I call "Figure 1 people." These are often smart young scientists who do some work in the lab, and then get incredibly excited by the very first thing they find - but then think they're done... when they've actually just started
Claude has discovered a previously unknown enzyme system hidden in the DNA of bacteriophages. Beside the enzyme’s gene sits a long array of repeating DNA—a structure that looks somewhat similar to CRISPR.
We don’t yet understand what this system does, but only a handful of known systems share its features, and all of them are able to cut, copy, and paste DNA. Historically, the discovery of such programmable systems has helped revolutionize medicine. CRISPR, for instance, is now the foundation of genetic medicines. But it will take much more work to learn what this system does, and whether it can be put to similar use.
Read more: anthropic.com/news/claude-di…
Matthew Wipperman retweeted
Below is a non-serious statement, and an example as to why the Aging field is at risk of being pulled into a vat of snake oil.
5 minutes in a sauna 4x/week reduces cardiovascular risk by 50%
Readers added context they thought people might want to know
Finnish data often cited here looked at men taking 4-7 sauna sessions a week lasting ≈ 15-20 min. That group had ~50 % lower cardiovascular death than men with 1 session. Five-minute sessions weren’t studied, and the study shows association, not proof of cause.
Source: pubmed.ncbi.nlm.nih.gov/25705824/
Matthew Wipperman retweeted
Nature research paper: Diet outperforms microbial transplant to drive microbiome recovery in mice.
go.nature.com/3YXbf0i
Matthew Wipperman retweeted
NEW WHOOP RESEARCH ON EXERCISE & SLEEP
I am proud to share that @WHOOP research has just been published in @Nature. Our study analyzed 4.3 million nights of sleep across ~15k WHOOP members to answer a simple but important question: does working out at night hurt your sleep?
Matthew Wipperman retweeted
How gut microbiome research needs to move forward. Going multi-omics, getting to causality, rigorous clinical studies cell.com/cell/fulltext/S0092…
Matthew Wipperman retweeted
My 2022 "Uniquely Stupid" article is back on @TheAtlantic's most popular list. It's about how morally homogeneous institutions became "structurally stupid" after social media made it easy for the extremes to attack and silence moderates and dissenters:
theatlantic.com/magazine/arc…
Matthew Wipperman retweeted
This study from @ScrippsRTI examined wearable data like step count, resting heart rate, & sleep to track changes in people with + without #LongCovid over a year.
Those with Long #Covid_19 had significantly different resting heart rate & activity levels. They were also more likely to be women, younger, unvaccinated, & report more acute-phase symptoms.
nature.com/articles/s41746-0…
Matthew Wipperman retweeted
Wearables let us study how #sleep differs between or within people. With 5 million nights of data, @varunknath et al. found that changes in sleep over time are associated with acute & chronic conditions inc. COVID-19, fever, flu, #diabetes & sleep apnea.
nature.com/articles/s41746-0…
Matthew Wipperman retweeted
Predicting Parkinson's disease up to 7 years before symptom onset with a panel of 8 protein biomarkers
@NatureComms
nature.com/articles/s41467-0…
(adds/orthogonal to the retina image that can do this well)
Matthew Wipperman retweeted
This perspective discusses how a convergence of progress by patients, advocates, developers, regulators & other stakeholders is driving real progress towards enabling more digital evidence tools to be used for decision making in #drugdevelopment.
nature.com/articles/s41746-0…
Matthew Wipperman retweeted
New Article in @eLife - Digital wearable insole-based identification of knee arthropathies and gait signatures using machine learning
@junkRNA @Regeneron @MoticonScience
@ISPGR @esmac2019 #digitalbiomarkers #digitalhealth #gait #walking #mobility
elifesciences.org/articles/8…
Matthew Wipperman retweeted
Open Access: Differential modulation of allergic rhinitis nasal transcriptome by dupilumab and allergy immunotherapy. First and corresponding author: Matthew F. Wipperman; corresponding authors: Jennifer Hamilton and Meagan P. O'Brien
Read the article here: doi.org/10.1111/all.16001
This study aimed to understand the pathobiology of allergic rhinitis (AR) by analysing transcriptome data from nasal brushing samples of individuals with and without AR, and those undergoing different treatments. The study evaluated how treatments, including #dupilumab, subcutaneous immunotherapy (SCIT), and a combination of both, versus placebo, influenced AR and allergen challenge specific gene signatures in nasal tissue. Results showed that both dupilumab and SCIT+dupilumab significantly repressed the AR disease signature, and all three treatments repressed the nasal allergen challenge (NAC) gene signature.
#Allergy_journal @junkRNA
Read more articles published in #Allergy on #rhinitis here: journalallergy.com/Rhinitis-…
Matthew Wipperman retweeted
Your weekend read editorial: Discussing the importance of shifting the focus towards clinically relevant outcomes, when adopting #ArtificialIntelligence tools, the ecosystem required for AI to succeed in health, & the human aspect of #healthcare.
nature.com/articles/s41746-0…
Matthew Wipperman retweeted
How many genes are in the human genome? (The third in an irregular series of threads about #Bioinformatics.) Let’s start by restricting “gene” to mean “protein-coding gene.” For the moment, this number appears to be just under 20,000, far lower than it used to be 1/11
Matthew Wipperman retweeted
This also makes a great case for preprinting -- a high-impact paper will get a lot of eyes on it before it gets published in a fancy weekly magazine.
Matthew Wipperman retweeted
It's a shame that this is drawing attention away from the incredible accomplishments of the @AllofUsResearch program in building a massive, diverse cohort that will fuel decades of important research.
Matthew Wipperman retweeted
Commensal bacteria in the gut #microbiome display surprising resilience to #antibiotics, evolve resistance mutations, and reestablish a healthy biome after treatment, shows a 20-month long study of patients with #tuberculosis. @BucciVanni @MichaelGlickma1 scim.ag/5A0
Matthew Wipperman retweeted
🧵 The historic NYT v. @OpenAI lawsuit filed this morning, as broken down by me, an IP and AI lawyer, general counsel, and longtime tech person and enthusiast.
Tl;dr - It's the best case yet alleging that generative AI is copyright infringement. Thread. 👇
Matthew Wipperman retweeted
Protein-protein correlations across single cells change dynamically even when the associated protein levels do not.
Protein correlation dynamics across single cells offer a rich perspective, richer than I described before: journals.plos.org/plosbiolog…
Our latest article is out:
It focussed on the proteome remodeling during epithelial-mesenchymal transition.
◼️ Much of the remodeling was reflected only in the protein covariation across the proteomes of individual cells.
biorxiv.org/content/10.1101/…
Matthew Wipperman retweeted
Well it's official, Hyperloop is finally dead.
It was my first gig out of academia and an incredible venue to learn from some of the best engineers in the world trying to build an impossible thing. We got damn close.
Also we got to speed run organizational drama next to which "Silicon Valley" pales in comparison.
I think it's unfortunate that very little of the inside story has made it out. It's way weirder and more interesting than public reporting has even hinted at.