staff scientist/Archer lab @FNucleosome team he/him - views/tweets are my own - also at https://teapawt.net/t.co/PucZW8OP5I
RTP, NC, USA
Joined January 2022
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Excited to finally share something we've been working on for a while now: biorxiv.org/content/10.1101/…
I'm super happy to now be able to share the published version of our paper at @ScienceAdvances showing that:
1) active histone mods occur independently of transcription
2) transcription coordinates histone deacetylation at active promoters
science.org/doi/10.1126/scia…
jackson hoffman retweeted
It has finally arrived: The first book written, and sold, in DNA.
Thanks @catalogtechinc and Imagene for making this happen!
Pre-orders are still open. If you order a capsule, we also send you a physical book. And those are cool, too.
Links here: press.asimov.com/books
Hey friends, you should sign up to give a talk to the @FNucleosome community this year!
Do you have an exciting chromatin/transcription story that you'd like to share with an enthusiastic audience?
If so, you should apply to give a talk in the 2025 Fragile Nucleosome seminar series: forms.gle/fwMYPFDf4az31peu8
We're open to scientists at all stages of their careers!
Hey NC/Triangle area folks: registration is now open for the annual Chromatin and Epigenetics Symposium at UNC on March 6th! This year's program will feature a keynote talk from @CKadoch and short talks selected from abstracts. Click to register: unclineberger.org/event/2025…
Jointly sponsored by C3 (Carolina Chromatin Consortium), UNC Integrative Program for Biological and Genome Sciences, @OoR_UNC, @NIEHS Epigenetics & RNA Biology Laboratory, @UNC_BCBP, and @UNC_Lineberger
jackson hoffman retweeted
In ~3 hours...
Dear Tweeters and Skeeters! For our next #FragileNucleosome seminar session, we are happy to host another three amazing ECR scientists: Sanne, Vivek and Thomas!
🗓️Don't forget to register:us06web.zoom.us/webinar/regi…
jackson hoffman retweeted
Latest research from the Teves lab is now out on Biorxiv!
"Functional divergence of TBP homologs through distinct DNA binding dynamics" biorxiv.org/content/10.1101/…
Here, we examine how conservation is balanced with diversification throughout evolution, using TBP as a case study.
jackson hoffman retweeted
Why did nature choose Dnmt3b? @Komal__Yasmin tells us about her work that's now on bioRxiv: biorxiv.org/content/10.1101/…, youtu.be/u2e0P3j1eHk
jackson hoffman retweeted
A big new batch of our @FNucleosome seminar videos have gone public in the past couple weeks! Here's a thread 1/9
jackson hoffman retweeted
Coming up in about 4 hours! Join us for talks from @alex_paynedwyer, @WilNart, and Xiukun Wang. Register here: us06web.zoom.us/webinar/regi…
In the midst of stressful times, let's come together to listen to 3 amazing talks by 3 brilliant ECR scientists. Alex, Wilson and Xiukun will present their research tomorrow at 9am PDT/ 5pm GMT/ 6pm CET!
Register:
us06web.zoom.us/webinar/regi…
Join us tomorrow!
In the midst of stressful times, let's come together to listen to 3 amazing talks by 3 brilliant ECR scientists. Alex, Wilson and Xiukun will present their research tomorrow at 9am PDT/ 5pm GMT/ 6pm CET!
Register:
us06web.zoom.us/webinar/regi…
jackson hoffman retweeted
Our new study, initiated by an undergraduate in the lab, was set to examine the effect of mutating histone H3.3 K122 to alanine. To do so, we attempted to generate murine ES cells mutating all four alleles, but were surprised when we couldn't generate these lines!
ALT model for H3.3K122A
jackson hoffman retweeted
📢Postdoc available! We are looking for curious minds to answer big questions using epigenome editing
Join us at @EMBLRome - we offer training, supportive environment, top salary and scientific excellence. Also - sun, culture & Italian food😉
Info+apply:
embl.org/jobs/position/RM001…
jackson hoffman retweeted
I am thrilled to start today @Caltech and looking forward to the exciting science ahead.
jackson hoffman retweeted
1/4 Our @biorxivpreprint, 'Origin of Ewing Sarcoma by Embryonic Reprogramming of Neural Crest to Mesoderm' is now available on bioRxiv! In this study, we explore the enigmatic origin of Ewing sarcoma using our zebrafish genetic cancer models. We revealed that neural crest cells can uniquely tolerate EWSR1::FLI1 expression, leading to tumor formation in vivo. A big thanks to our collaborators @clairearataphd and @CrumpLab for this adventurous journey! #NeuralCrest #cancer #EwingSarcoma #zebrafish @amatrudalab @ChildrensLA @biorxiv_cancer👉biorxiv.org/content/10.1101/…
jackson hoffman retweeted
📢 calling prospective postdocs! Only a few days left to apply to join our growing group in the beautiful city of Edinburgh to lead an exciting project focused on how gene expression, RNA metabolism and cell signalling are all coordinated with changes in cell size.
Starting in 4 hours - register and join us! @FNucleosome @epicypher
🎃In our next session of #FragileNucleosome seminar series, we have two amazing speakers from UK, Alan Jiao and @mpswaffer !
🗓️Save the date and register now:
us06web.zoom.us/webinar/regi…
jackson hoffman retweeted
1/n Looking into history of "fragile nucleosomes". The term was introduced in Xi et al, 2011 genome.cshlp.org/content/21/……. But before that, MNase-sensitive nucleosomes were known as "labile nucleosomes", since 1970s academic.oup.com/nar/article…. This term then continued into the NGS era