Cancer Metabolism and Systems Toxicology lab group @imperialcollege #Cancer #Metabolism #Research
London, England
Joined February 2017
- Tweets123
- Following156
- Followers304
- Likes60
Our latest paper linking the #metabolome #epigenome and #transcriptome to the #exposome (chemicals, diet, environment) in six populations of children across Europe nature.com/articles/s41467-0…
Our latest paper in which we show how targeting RNA splicing can impact tumour metabolism and could be a new way to treat an aggressive childhood cancer. Great collaboration with @ICR_London @MRC_LMS Congrats to @Artiska2 Anke Nijhuis and Orli Yogev nature.com/articles/s41467-0…
Keun Lab retweeted
Reliable measurement of diet from self-report is notoriously difficult. Evidence from @BiBresearch & sister cohorts shows potential for urinary markers
Urinary metabolic biomarkers of diet quality in European children are associated with metabolic health doi.org/10.7554/eLife.71332
Pleased to announce our latest #exposome paper as part of the #ATHLETEproject, in which we define a metabolome signature of diet quality in children linked to metabolic health. Congrats to @AlexandrosSISK1 & @ChatziLab elifesciences.org/articles/7…
The #ATHLETEproject follows thousands of mothers and children across Europe to measure how the #exposome affects their health. Find out more here bit.ly/3tW4ayx
Keun Lab retweeted
An international research team, including @hectorkeun and @AlexandrosSISK1 from S&C, has identified metabolic ‘signatures’ in urine that can determine the quality of diets in children across Europe and predict their metabolic health. imperial.ac.uk/news/233335/u…
Very pleased to have contributed to this great paper from @auner_lab_ICL on stress resolution in multiple myeloma cells recovering from proteasome inhibition. Follow thread to find out out more 👇
How do #cancer cells that survive chemotherapy resolve stress? Turns out it’s complex & generates druggable weaknesses. See our new paper now out in PNAS (1/8).🧵pnas.org/content/118/17/e201…
Keun Lab retweeted
How do #cancer cells that survive chemotherapy resolve stress? Turns out it’s complex & generates druggable weaknesses. See our new paper now out in PNAS (1/8).🧵pnas.org/content/118/17/e201…
Keun Lab retweeted
Distinguishing between vaccine efficacy and effectivenesss, looking at relative risk reduction (RRR), absolute risk reduction (ARR) and numbers needed to vaccinate (NNV) thelancet.com/journals/lanmi… @LancetMicrobe by @ElsTorreele @IIPP_UCL and colleagues
Keun Lab retweeted
Another PhD that'll be formally advertised soon - this time through @STRATiGRAD Proj w/ Prof Iain McNeish @ImperialSandC & @AstraZeneca > biomarker discovery & instrument development for ovarian cancer. Interested or know anyone that might? Get in touch. RTs appreciated!
Keun Lab retweeted
A big moment for me - 20 years ago today I started at @imperialcollege ! It has been a lot of fun, so lucky to have worked with so many brilliant and supportive colleagues. Thank you to all @keun_lab past and present👏you are amazing (And of course the best is yet to come... !)
Keun Lab retweeted
Recently published in @BrJCancer:
Pre-clinical research demonstrates lactic acidosis in cancer induces Akt inhibitor resistance. Interfering with lactic acid uptake reversed resistance to the Akt inhibitor, uprosertib.
@keun_lab @imperialcollege
go.nature.com/2IGGbud
Our latest paper in which we show that lactic acidosis protects cancer cells from cell death induced by the pan-Akt inhibitor uprosertib, and how the effect can be reversed by metabolic inhibitors #cancermetabolism #tumormicroenvironment #drugresistance
rdcu.be/b2J1G
Keun Lab retweeted
Japan: Intercellular signal transduction during the assembly of slime mould cells • cAMP-sensitive fluorescent probes • signal is transmitted as a spiral wave within the group • amazing • via @kotapub dx.doi.org/10.1038/s42003-01…
Our latest paper where we studied which microRNAs can be measured stably over time in serum, a factor in making them good biomarker candidates. What we found was a surprising link to maternally imprinted genes
#geneimprinting #microRNAs #biomarkers
nature.com/articles/s41598-0…
Congratulations to past @keun_lab member @JudithPape3 for passing her PhD viva! @3dmodelsucl #PhD #congratulations
Keun Lab retweeted
(1/4) Check out our latest work on GOT1 metabolism in pancreatic cancer #Preprint #OpenAccess @biorxivpreprint! – at Ann Arbor, MI
Tissue of Origin Dictates GOT1 Dependence and Confers Synthetic Lethality to Radiotherapy biorxiv.org/cgi/content/shor… #bioRxiv
Keun Lab retweeted
Check out our latest preprint on @biorxivpreprint on the role of #lncRNAs in cell division.biorxiv.org/content/10.1101/… …
Great collaboration with Aaron Lun, @MascalchiP @ChristinaErnst_ @Alexis_Barr @BakalLabICR @MarioniLab Duncan Odom & @fanni_gergely
Keun Lab retweeted
My lab is recruiting an LCMS expert to work on challenging cancer metabolism projects. Experience with LCMS critical, ideally a postdoc...
jobs.ac.uk/job/BTS529/resear…
#cancermetabolism #metabolomics #pushingbackthefrontiers #Glasgow