Louise Basham retweeted
Alzheimers originates in the nose ?!?
sciencedirect.com/science/ar…
Louise Basham retweeted
Thanks for having me on Nick. It’s been pretty hard to cut through the political soap opera these past few weeks.
But keeping up the awareness of our public #nottinghaminquiry is so important.
We must make sure the failures are uncovered and accountability held.
Much love to you all 🫶
Morning,
On the show:
🗳️Andy Burnham launches bid for No 10 as Labour MP stands down for him to run
🚨Mother of Nottingham killer tells inquiry 'system is so broken'
🎙️I'll speak to Reform UK's Richard Tice as pressure builds on Nigel Farage over £5m gift
@LBC 0345 60 60 973
Louise Basham retweeted
Did you know that appendicectomy is a valid treatment in ulcerative colitis? This is what you need to know about the recent ACCURE trial ✂️
Louise Basham retweeted
- 9yo boy referred to A&E by GP with suspected appendicitis
- Never seen by a doctor. The hospital says it ‘couldn’t identify who saw the patient’
- Discharged
- Getting worse, his father calls 111 (non-emergency line)
- No answer for 2h, is triaged to get a call back from a clinician
- Gets even worse. Parents take him back to A&E.
- Diagnosed with a ruptured appendix and dies of septic shock.
leighday.co.uk/news/press-re…
Louise Basham retweeted
How many doctors realise that high serum B12 can coexist with functional B12 deficiency?
This simple question from a medical student two years ago led to the paper below - and sparked quite a conversation on Twitter. It was fascinating to see practitioners and patients from across the world chip in with their thoughts and experiences.
I’m delighted that the main author of this paper - @HamzaAMahmood21 - a bright @uclmedsci alum and now a doctor at @FrimleyHealth, has joined X/Twitter. Hopefully he’ll take this important conversation further with his upcoming systematic review on elevated #B12. @dr_pratimasingh
Elevated serum #B12 can be a sign of B12 deficiency!
Pseudo-hypercobalaminaemia occurs because circulating B12 is bound to inactive proteins or immune complexes (e.g. macro-B12), leaving intracellular delivery via transcobalamin impaired, so functional deficiency persists despite high total B12. This matters because clinicians may falsely reassure themselves, missing deficiency & underlying disease while neuropsychiatric symptoms continue.
In our preliminary UK survey of 46 GPs examining responses to raised B12, not a single respondent identified pseudo-hypercobalaminaemia, revealing a major blind spot in clinical reasoning. Survey was led by Hamza Mahmood @FrimleyHealth & co-supervised by @dr_pratimasingh @HPFT_NHS
Read it in full here: cureus.com/articles/445300-e… #openaccess @neuropsych_ucl @uclh @UCLIoN
Louise Basham retweeted
@BBCHughPym @BBCFergusWalsh @NickTriggle @nikkijfox 55% ICBs refuse to follow NHSE guidance on Liothyronine. Tens of 1,000s thyroid patients (almost all women) left extremely unwell, unable to work. This scandal needs highlighting urgently. Please contact @campaign_itt
Louise Basham retweeted
Meanwhile @BBCHughPym most hypothyroid patients are STILL refused Liothyronine (T3) they need in order to function. This isn't about weight; it affects evry aspect of our lives. The scandal began in 2016. Thyroid groups/charities fighting hard.
Please can we discuss with you?
Louise Basham retweeted
My wife Jen tells me that my friend @BenBikmanPhD is tweeting on recent evidence indicates that adding metformin to exercise antagonizes the exercise-induced improvement in insulin sensitivity and cardiorespiratory fitness. Here is a paper that backs Ben up pubmed.ncbi.nlm.nih.gov/3054… @ProfTimNoakes @grantsnz @nnedpro @AKoutnik
Louise Basham retweeted
Lithium deficiency might underpin Alzheimer's
Lithium levels are low in the brains of Alzheimer's patients and – in mice – replacing lithium (with a particular salt, lithium orotate) helps clear amyloid plaques and improve cognition
Louise Basham retweeted
The story of JERMAIN DEFOE is worth reading:
"I remember during my second season at Sunderland, Louise Wanless, the press officer, told me one day: 'There’s a boy who wants to meet you.' She explained that Bradley Lowery had neuroblastoma and that I was his favorite player. I was like, 'Alright, of course. No worries.' But I had no idea what he would be like. From her description, I assumed he’d be super shy and quiet.
But as soon as he walked into the dressing room, he ran straight to me, jumped on my lap, and hugged me with a big smile on his face. After that first meeting, I asked Louise to put me in touch with the family so I could visit him at the hospital. At first, I went with other players, but then I started going alone. I wanted to spend as much time with him as possible. We had this natural connection, this bond. I still don’t know how to explain it. I got so used to having him at Sunderland that I really struggled after he was gone.
He taught me to appreciate life and the people around me so much more. He changed me, my whole perspective."
Louise Basham retweeted
A moment of stillness today for this. Every lost child, every child surviving without their friend, every parent, every grandparent, every teacher, every rescue worker, every emergency service worker.
Louise Basham retweeted
Please re-Tweet if you agree that the confusion, frustration, anger, and loss inflicted by dementia sometimes becomes overwhelming.
#Alzheimers #dementia #quote
Louise Basham retweeted
For every retweet of this post, I will donate £1 to the @VC_and_GC_Assoc up to £50,000.
Time is running out following @I_W_M’s decision to close the Lord Ashcroft Gallery.
Visit while you still can, to honour the bravery of those who risked so much to protect our great nation.
Louise Basham retweeted
Neuralink will do live-changing good for ultimately millions, maybe billions, of people.
Imagine your loved one being able to walk again or your parent with dementia being able to recognize their child again.
Louise Basham retweeted
Neuralink's implant could help Alzheimer's by interfacing with the brain to stimulate neurons, bypass damaged areas, and potentially restore cognitive functions like memory recognition. Elon Musk envisions it aiding dementia patients to recall loved ones, though it's still in early development focused on motor restoration.
Louise Basham retweeted
The theory now is that longer wavelengths of light specifically from sunlight restore membrane potential in your mitochondria, whereas shorter wavelengths of light (such as from LEDs) reduce it. This needs testing, but it’s intriguing & brings together a lot of data.
Very cool paper. “Longer wavelengths in sunlight pass through the human body and have a systemic impact which improves vision” I have known the senior author Glen Jeffery since the mid 90s and he’s always done very interesting work. Another beauty here.
nature.com/articles/s41598-0…
Louise Basham retweeted
Immune Dysfunction May Drive Alzheimer's Progression
A new study reveals that immune system dysfunction may play a central role in the onset and progression of Alzheimer’s disease.
Researchers used RNA sequencing in an animal model to show that neuroinflammation, innate immune memory, and cellular reprogramming are tied to disease mechanisms.
Their findings suggest Alzheimer’s may function partly as an autoimmune disorder, triggered by maladaptive immune responses to internal molecules like amyloid-beta and tau.
This adds a new dimension to traditional views that focus mainly on amyloid plaques and tau tangles.
Chronic immune activation appears to sustain damaging inflammation, accelerating brain degeneration.
These insights open new avenues for potential therapies targeting immune pathways rather than focusing solely on amyloid or tau.
ALT This shows a brain.