Wow! Peter Visscher and colleagues have published a provocative paper in Nature speculating that "polygenic gene editing" of embryos might prove effective in reducing disease risk, should the technology advance enough to become safe in the future. The authors argue that for polygenic diseases like type 2 diabetes or schizophrenia, theoretically, editing only a handful of variants might produce dramatic reduction in the disease prevalence among the edited embryos. And this approach will prove more effective than embryo screening. Of course, the authors have acknowledged that this is speculative and discussed all the challenges and ethical issues associated with embryo gene editing. Further, Nature has thoughtfully published a well-balanced News and Views titled "Human embryo editing against disease is unsafe and unproven — despite rosy predictions" by experts in this topic (@ShaiCarmi @WiringTheBrain and @HankGreelyLSJU) arguing that though theoretically possible the idea might never work. Visscher et al. Nature nature.com/articles/s41586-0…