Tech, AI, Space and some sports
Joined January 2009
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Lukas Gräf retweeted
With AlphaFold we mapped the protein universe - now with AlphaGenome Atlas we’re charting the human genome. It can predict the impact of all 9 billion possible single-letter DNA variants, helping scientists better understand disease. Freely available for academic research: alphagenome.google/atlas
Lukas Gräf retweeted
We’re in orbit! And just made European history: This is the first time a privately developed rocket reached orbit from continental Europe; and a testament to the dedication, expertise, and teamwork of everyone involved.
Lukas Gräf retweeted
It finally finished, here's the final output. Used 60% of my monthly Kimi usage on it
macos27.kimi.page
Lukas Gräf retweeted
In 2015 a writer named Tim Urban sat down and counted the days he had left with his parents. He was 34, healthy, both parents alive and well. The number came back around 300. Less time than he spent with them in any single year of his childhood.
The post is called The Tail End, on a blog called Wait But Why. The idea is to stop counting your life in years and start counting it in events. Reach 90 and you get about 4,680 weeks, and every one of them fits on a single sheet of paper. Maybe 60 more winters after that. If you read five books a year, that is 300 books, picked from every book ever written.
Those things at least spread out evenly. A third of the way through life means a third of the way through your pizzas. Time with the people you love does not work like that. Almost all of it sits at the very start. Then it is gone.
For your first 18 years you are around your parents nearly every day. Then you leave for college or a job in another city, and a normal adult sees their parents maybe 10 days a year. So the day you move out, you are already at 93 percent. Urban was living in the last 5 percent and had no idea until he drew the chart. He called it the tail end.
It does not stop at parents. His two sisters, after a whole childhood in the same house, had around 15 percent of their time together left. The four friends he played cards with most days in high school were down to their last 7 percent. Nobody had a fight. Nobody moved away angry. Life quietly spends the time for you while you assume there is plenty left.
You do not have to be old to be near the end with someone. If your parents are alive and you live in a different city, you have probably already used more than 90 percent of the days you will ever spend in the same room as them.
His one instruction is about that last stretch. When you are down to the final days with someone you love, treat that time like what it is, which is almost gone. The rest is the tail end, and it is much shorter than it feels.
Lukas Gräf retweeted
Lee Kuan Yew:
“Air conditioning was a most important invention for us, perhaps one of the signal inventions of history. It changed the nature of civilization by making development possible in the tropics. Without air conditioning you can work only in the cool early-morning hours or at dusk. The first thing I did upon becoming prime minister was to install air conditioners in buildings where the civil service worked. This was key to public efficiency."
Lukas Gräf retweeted
Today we're sharing our work on interaction models. A new class of model trained from scratch to handle real-time interaction natively, instead of gluing it onto a turn-based one.
youtu.be/A12AVongNN4
Lukas Gräf retweeted
"Planet Earth: You. Are. A. Crew."
Artemis II mission specialist Christina Koch reflects on what it means to be a "crew."
Lukas Gräf retweeted
We released Claude Opus 4.6 just two months ago. Today we're sharing some info on our new model, Claude Mythos Preview.
Lukas Gräf retweeted
Overall, significant upgrade to the American diet. Some longevity tweaks:
0. Milk and dairy should be deprioritized and moved down the inverted pyramid, especially for adults. In adults, and particularly men, milk protein has an unfavorable amino acid composition, being high in Branched-Chain Amino Acids (BCAAs). BCAAs have been linked to metabolic disease and preclinically shown to accelerate cancer growth. BCAAs, especially leucine, are potent mTOR activators; while essential for growth, repair, and survival, mTOR hyperactivation accelerates aging and is a common mechanism underlying several chronic diseases.
Milk protein has been associated with inflammation, blood glucose dysregulation, and weight gain in some mechanistic and observational studies; however, randomized controlled trials show inconsistent effects. In a longevity-focused context, high dairy-derived BCAA intake may nonetheless contribute to metabolic stress, including impaired glucose handling and weight gain, in susceptible adults and is therefore best moderated.
Saturated fatty acids are another concern. The American Heart Association recommends limiting saturated fat to 5–6% of total energy (around 13 g/day at a 2,000 kcal intake) when targeting LDL reduction, which is particularly important for men over 40 and post-menopausal women, high-risk groups for cardiovascular disease, still the leading cause of death in developed societies including the US.
1. Legumes should have their own prominent category, placed high on the pyramid as a primary protein and dietary fiber source. Plant-based protein has been associated with better health and longevity outcomes in several large population studies across various societies, including the US. Legume fiber has health promoting qualities, including the reduction of colon cancer risk.
2. Meat belongs on the pyramid but with an emphasis on high-quality, non-processed sources. It should occupy a lower rank and be optional, especially for adult men. Red meat is associated with increased chronic disease and mortality risk in multiple large population studies. These results might be confounded by healthy user bias and a lack of specific information about meat sources. However, processed red meat is strongly implicated in driving chronic age-related disease and shorter lives in all studies. The same concern about saturated fats applies here, especially for men over 40 and post-menopausal women.
3. Healthy fats (unrefined cold-pressed oils, nuts, and fatty fish) belong at the top, next to legumes and vegetables. Olive oil, avocados, and macadamia nuts are rich in healthy Monounsaturated Fatty Acids (MUFAs) shown to reduce heart disease and all-cause mortality risk as part of Mediterranean-style dietary patterns demonstrated in large randomized controlled trials.
Fatty fish and walnuts are rich in Omega-3 fatty acids, which are essential for lowering cholesterol, providing systemic and vascular anti-inflammatory protection, and slowing down biological aging in interventional studies, along with vitamin D.
What it did well: shifted away from highly processed starches and added sugars toward protein and fat rich foods
Children are well positioned to benefit from the highly anabolic effects of milk and red meat proteins and are least affected by the risk of saturated fats, provided these are part of a relatively balanced diet.
Lukas Gräf retweeted
get into the habit of taking a 10 min walk immediately after eating. top tier thing for health.
+ blunts blood glucose by 17%
+ lowers triglycerides by 72%
+ accelerates digestion
+ lowers blood pressure 5 mmHg
+ improves sleep
Lukas Gräf retweeted
To get your head right for 2026
Download wisper flow.
Find your local forest / park and go on a long walk voice noting everything that is on your mind from the past year and everything you want to achieve in 2026.
Straight off the Dome. A pure stream of consciousness.
Then copy and paste into your LLM and ask it to analyse the key points, summarise any patterns and give insight into what blind spots you may be missing.
Lukas Gräf retweeted
There’s this metaphor in Chinese business strategy that you see all the time, even though you never really hear it in Western business schools (at least I haven't). It’s called the “catfish effect,” and it supposedly comes from a Norwegian fishing practice.
Apparently, when fishermen would transport sardines in tanks, a lot of them would die along the way because they’d stop moving and run out of oxygen. But if you put a single live catfish into the tank, the sardines would stay active, swimming constantly to avoid getting eaten, and more of them would survive the journey. The catfish made the environment slightly hostile, which weirdly made it more survivable.
This story kind of floated around in Western motivational books for a while, but it never really stuck in business theory the way things like disruptive innovation or lean operations did. In China though, the idea of the catfish effect, or 鲶鱼效应, became pretty popular in corporate training settings and state-aligned business commentary, and it's pretty obvious that a main reason for that is cultural. There’s just more acceptance of discomfort as a developmental tool, and less hesitation to design pressure into the system from the top down. It’s not “disruption” as a natural market phenomenon, it’s more like managed agitation. Like, let’s introduce a little stress on purpose, because stagnation is the bigger risk here.
And yeah, I'm sure some will disagree with this example, but in China, Tesla's arrival is considered a clear-cut case of the catfish effect in policy. At the time, the government was pretty frustrated with its domestic EV scene. The subsidy program, although improved from the decade prior, had still led to all kinds of abuse and fraud, with a bunch of half-baked companies just trying to cash in on government money without building anything truly innovative. It was getting embarrassing.
So the government said, okay, fine. Let’s put a catfish in the water. They gave Tesla this rare set of approvals -- full ownership of their China operations, fast-tracked factory deals, land, logistics support -- the works. It was a provocation. Like, hey all of y'all Chinese companies, you guys need to be way faster cuz here comes the catfish. Swim! And sure, it wasn't all because of Tesla, but the pace of innovation has indeed picked up since then, in operations, design, user experience, everything.
This is where it really differs from how Western business theory tends to approach competition. In the US, you see a lot more disruptive innovation. In China, competition can be curated, introduced, even welcomed -- not to destroy the domestic players, but to get them moving again.
Of course, it doesn’t always work. Sometimes the catfish is too strong, or the sardines were already too weak. And sometimes you get eaten, LOL. But it's an interesting question -- is that tank you're in the best environment for you? Are you swimming because you want to, or because you finally have to?
Lukas Gräf retweeted
The most annoying phrase I hear at the moment is rich people giving advice to people telling people to just ‘learn AI’
What does ‘learn AI’ even mean? It’s a phrase by people who have not the faintest idea of what AI is.
Too put you ahead of the curve I suggest these three things to ‘learn AI’
1) develop and understating and learn how LLM’s work. Get a basic level understanding of how machine learning works and what it is. You’re not going to be a Machine Learning Engineer, just learn more then the average man on a street and hold a conversation about the topic.
2) pick a new emerging software and go all in. There are riches in being experts in softwares. Salesforce developers make bank. People have made millions by understanding how shopify works and creating services around that. At the moment it looks like N8N is the best bet of one to learn.
3) Re-evaluate your tech stack and ask yourself if you can rebuild it with AI. Not to sell, but for personal use. Re-create your website using Lovable and host it for free on netlify. Replace your social media post scheduler with your own.
This way you will learn how re world apps work, understanding back and front end and how API’s work.
When everything becomes more and more autonomous it will be people who understand why and how it works are the ones who will remain employed.
Those who just know what it does will be replaced.
Lukas Gräf retweeted
Sports television at its finest. Barely a word said by CBS over nearly 7 minutes.
Lukas Gräf retweeted
Launch, learn, repeat.
#fromisartospace #goingfullspectrum
Lukas Gräf retweeted
Patrick asks a great question:
Why is Europe's productivity behind the US?
Everyone says Europe is stuck in decline
But is that the full story?
What's really going on?
I sat down with @yoramdw of @dealroomco to understand the newest data
Here the ultimate Eurodata breakdown⤵️
