Computational Biologist @DanaFarber | Associate Editor @PlantMethods | She/Her | retweets != endorsements | Find me @miachom.bsky.social instead
Boston, MA
Joined July 2011
- Tweets330
- Following837
- Followers232
- Likes953
Pinned Tweet
The latest issue from @CellCellPress today features our recent publication as Cover picture! Check out how X-chromosome rearrangements can partly explain the female predominance that we observed in this kidney cancer subtype!
The new issue is out 👉cell.com/cell/current
Featuring how X chromosome genetics constrains somatic alterations and underlies cancer sex differences, the functional mapping of RAD51C variants in cancer and single-cell genomics identifying markers of neuronal vulnerability and glial states in neurodegenerative disorders.
The cover image shows a stylized representation of a rearrangement of the inactive X chromosome that causes activation of X-linked oncogenes (colored region).
📷credit: Hans Haag Studios.
To save myself from insanity and bots, I’m no longer active in this platform. Please find me at Bluesky instead with the handle @miachom.bsky.social
Mingkee Achom retweeted
🚨 New study! 🚨Excited to share our research on #translocationRCC #tRCC published in @NatMetabolism, in collaboration with @lironbarpeled. We reveal how the TFE3 fusion drives a key oxidative phosphorylation (OXPHOS) metabolic program in this kidney cancer. 1/ @DanaFarberNews
Mingkee Achom retweeted
Our @DanaFarber_GU colleague @srviswanathan awarded today the Team Science Award for his basic work on X chromosome and translocation renal cancer !
@harvardmed @DanaFarberNews @DanaFarber
Throughout my career, I had heard many people say computation is just a tool with no impactful biology. Well, this year’s Nobel theme seems to resonate around big predictive biology from big data! :)
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
Mingkee Achom retweeted
What kind of childhood makes a top scientist? Is it enough to have all the right traits (brilliance, grit, etc) or do you need the right family too?
And why should we care? A 🧵 on our paper on the Nobel Laureates.
A teaser: the income distribution of the laureates' fathers.1/N
Small and micro but mighty RNA!
This year’s medicine laureates Victor Ambros and Gary Ruvkun studied a relatively unassuming 1 mm long roundworm, C. elegans.
Despite its small size, C. elegans possesses many specialised cell types such as nerve and muscle cells also found in larger, more complex animals, making it a useful model for investigating how tissues develop and mature in multicellular organisms.
Read how the 2024 medicine laureates’ investigations into C. elegans revealed an entirely new dimension to gene regulation: bit.ly/4dlPE6f
#NobelPrize
Mingkee Achom retweeted
Today's @NobelPrize to Ambros and Ruvkun an impt reminder of how much of our knowledge about human health and disease stems from foundational basic science & discoveries in model organisms - even when arc to translation may be very long.
This Post is from an account that no longer exists. Learn more
Mingkee Achom retweeted
Our paper on how X chromosome alterations drive sex differences in translocation renal cell carcinoma is now out in print @CellCellPress! Link to explainer thread if you missed it 👉: teapawt.net/srviswanathan/status/1…
The new issue is out 👉cell.com/cell/current
Featuring how X chromosome genetics constrains somatic alterations and underlies cancer sex differences, the functional mapping of RAD51C variants in cancer and single-cell genomics identifying markers of neuronal vulnerability and glial states in neurodegenerative disorders.
The cover image shows a stylized representation of a rearrangement of the inactive X chromosome that causes activation of X-linked oncogenes (colored region).
📷credit: Hans Haag Studios.
Mingkee Achom retweeted
Thank you @CD_AACR for highlighting our work on #ResearchWatch!
Read Cancer Discovery's #ResearchWatch: X Chromosome Translocations Drive Sex Bias in a Rare Kidney Cancer Subtype. bit.ly/3TnIabJ
Mingkee Achom retweeted
My favourite discovery ever has just come online. Can I please tell you about some seriously wacky molecular biology? The story starts with a reverse transcriptase that SOMEHOW defends bacteria from viruses.
(👇 I recommend sound ON for the video 🎹)
1/
Mingkee Achom retweeted
Liquid biopsy in renal cell carcinoma | @OncJournal | with @MarcMachaalani @KarlSemaan @marc_eid @RashadNawfal @RazaneHChehade @SylvanBacaLab from @DanaFarber_GU
academic.oup.com/oncolo/adva…
Mingkee Achom retweeted
Our own @DanaFarber_GU super star physician-scientist @srviswanathan and team committed to unlock the mysteries behind this rare #kidneycancer subtype : Translocation Renal Cell Carcinoma
@DanaFarber @DanaFarberNews @OncoAlert
His paper is in @CellCellPress !
Our study on sex differences in Xp11 translocation renal cell carcinoma is out @CellCellPress! We ascribe a genetic basis to the female bias in tRCC, which is driven by a translocation of the TFE3 gene on the X chromosome. w Zhang lab @danafarbernews bit.ly/4dtpNtP 🧵1/
We’re just one of the many examples that science cannot excel when done in solitude! Extremely grateful to be a member of such a dynamic group and proud to be a mentee of @srviswanathan. I keep learning every day!
This was true team science & only possible b/c of close collaboration w/ C-Z Zhang lab, talented co-first authors @m_achom @sadagopan_A @ChunyangBao & coauthors. 10/
Mingkee Achom retweeted
Our study on sex differences in Xp11 translocation renal cell carcinoma is out @CellCellPress! We ascribe a genetic basis to the female bias in tRCC, which is driven by a translocation of the TFE3 gene on the X chromosome. w Zhang lab @danafarbernews bit.ly/4dtpNtP 🧵1/
A year after we put it at bioRxiv, I am thrilled to see our work and effort on female sex-bias of translocation renal cell carcinoma (tRCC) to be finally online on @CellCellPress! A 🧵
cell.com/cell/fulltext/S0092…
7/8 Feel free to learn more about our exciting findings of how X chromosome reactivation can explain cancer sex-bias using whole genome sequencing, bulk-RNA seq, scRNA-seq and methylation data!
8/8 Lastly, many thanks to all of our hardworking co-authors especially @Sadagopan_A and Chunyang for their extensive contributions and to the reviewers for their valuable suggestions that improved this paper significantly!