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Joined May 2009
Mark Daniel retweeted
Researchers cut open the brains of Alzheimer’s patients and found a bacteria living inside 90% of them. It’s the exact same bacteria that lives in your mouth right now. we’ve treated Alzheimer's as a genetic curse. A random misfolding of proteins. An inevitable disease of aging. We poured billions into trying to clear amyloid plaques out of the brain. It hasn't worked. But, a landmark paper published in Science suggests we might have been looking in the wrong place entirely. Researchers analyzed the brains of Alzheimer’s patients and found something that should not be there. Porphyromonas gingivalis. That is the exact same bacteria responsible for chronic gum disease. It turns out, this bacteria doesn't just stay in your gums. It travels. It crosses the blood-brain barrier. Once inside your brain, it releases highly toxic enzymes called gingipains. These enzymes literally chew up and destroy human neurons. When researchers infected healthy mice with this exact gum bacteria, the mice developed the exact same amyloid brain plaques that define Alzheimer's. This flips our entire understanding of the disease upside down. We thought the amyloid plaque was the disease. It turns out, the plaque might just be the brain's immune system desperately trying to trap a bacterial infection. The researchers didn't just find the problem. They tested a solution. They designed a drug that blocks these toxic bacterial enzymes. When they gave it to the infected mice, the brain damage stopped. The neurodegeneration halted. We have spent generations terrified of losing our minds to an incurable, invisible enemy. But the front line of defense against cognitive decline might not start in a billion-dollar neurology lab. It might start with dental floss.
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Sixteen years ago, when @William_Blake and I were on the founding team of the Thiel Fellowship, we called it an older young person’s homeschool program. In a very Thiel-ian way, we built something that fostered independent thinking by giving young people permission to explore what interested them in an environment that trusted them to make decisions and execute on their work. @firstround’s editorial team wrote a really thoughtful piece about those first years of the fellowship. It also covers my journey — going from school founder to handing out $100K grants to teenagers. So wonderful to chronicle that very special time that has become the genesis of 1517 💗 (Link in comments)
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Michael and I were on the founding team of the Thiel Fellowship and left to scale our work backing young ambitious minds and builders before anyone else. 1517 turns 12 next year. And though we fly humbly under the radar, you know some of our greats: Lambda, Loom, Mach, Positron, ntop, Deepgram, Rainmaker. As of last week, Fund I is at a 5X DPI. We were the first check before anyone else would have a serious conversation with these founders and by doing that, we (a teacher and philosopher) have turned $20M into over $100M which doesn't even include our SPVs to continue driving our wins home. There is nothing like building a small community that you believe in before anyone else, you see something special and cultivate the hell out of it, and then grow that into a force of nature with multiplying effects. Best is yet to come!
One of the crazier facts about venture is that it seems consistently possible to build a small community of college-aged kids that is incredibly talent dense, e.g.: - Thiel Fellows (ETH, Figma, I think Cognition) - KP Fellows (Opensea, also Figma) - Dorm Room Fund (Cursor) - Prod (Mercor, Etched, also Cursor) - Neo Scholars (Cog, also Cursor) Other than Neo (@neo) though, this hasn't really become anyone's dominant strategy.
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Mark Daniel retweeted
Today we're announcing our Series D: $1.37B in new capital at a $7.87B valuation to Reindustrialize America. Thank you to all our investors. WCM Investment Management, @WashingHarbour, Valor Equity Partners, @137ventures, and @BaillieGifford led the round. @jpmorgan Chase's Strategic Investment Group acted as anchor co-lead, investing through the firm's Security and Resiliency Initiative. The round also included major participation by @1789capital, as well as participation from @MorganStanley Wealth Management, @apolloglobal, @TRowePrice, @a16z, @CapitalG, @foundersfund, @lux_capital, @AltimeterCap, @constructcap, and existing investors. This round confirms our belief in a few simple things: America needs to Reindustrialize, Physical AI is real, transforming the world of atoms matters 100x more than the world of bits, and, most importantly, that the New American Workforce is the center of everything we do. Here's what we've built, and what comes next.
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Mark Daniel retweeted
After 15 wonderful years @generalcatalyst I am moving on to new adventures. The best days for GC are ahead! Super grateful to every single one of my teammates that I had the fortune to work with over the years. I learned a lot. Very thankful to our limited partners too for their long-term support. Equally importantly, it's been the privilege of a lifetime to work with so many inspiring tech startup founders from the very early days.
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Mark Daniel retweeted
**how @joinswsh went from a greek life photo sharing app to powering the world's largest events** @joinswsh is building shared albums for live experiences first, it was campus life - Greek Week, parties, tailgates. then swsh users took us with them: to concerts, music festivals, and game days. so we followed. now, we power the world's largest events including @RollingLoud, @BreakawayFest, @nyjets, @insomniacevents, @EDC_LasVegas, and more ready to take your event to the next level, let's get use swsh-ed up learn more here: joinswsh.com/
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🚀 Big day for EWOR! We’re committing €60M to back the world’s most exceptional founders in building game-changing companies. Empirically, EWOR Fellows raise €1M - €11M before even finishing the fellowship. (1/4)
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Vices that look like virtues are more dangerous than vices that look like vices
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Mark Daniel retweeted
I’m launching Topology, an early-stage venture firm dedicated to frontier technology. We've raised an oversubscribed $75M Fund 1. Topology backs founders who put everything on the line to bend the arc of human progress. Meet us at the edge. @topology_vc
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I’m extremely honored to be nominated by @realDonaldTrump and excited to support @RobertKennedyJr and the great people of @HHSGov to make America healthy again.
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Had to see it to believe it. Instagram, WhatsApp, Google, TikTok, YouTube, Uber ...and Polymarket. The election will pass, but Polymarket as a format of information for the masses, and a way of thinking about current events + the future, is unquestionably here to stay.
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who would’ve predicted this
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Emerging evidence suggests falling fertility rates are partially influenced by endocrine disrupting plastics
Replying to @natfriedman
Seems like the majority of us are eating a lot of plastic every day, and this might be having society-level effects that we attribute to other things
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Mark Daniel retweeted
HADRIAN DEEP DIVE DOCUMENTARY It covers: - Competition with China - The massive $117 million Series B - Why America must win space race 2.0 - How to combine manufacturing & software talent - Why an Australian is fixing American manufacturing
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Honored to host George Church, PhD - Professor of Genetics at Harvard Medical School & pioneer in genomics on ep2 of pod! "I think the trend is going to be towards everybody getting IVF as the main way of having babies. I think that's a plausible future." @geochurch
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Mark Daniel retweeted
BIG @ACMomento update live in the App Store... and we think you are going to love it. We are introducing our own Scores product, with the initial goal of delivering the fastest and easiest to use multi-sport Scores experience in the industry. ⚡️ To learn more, see my next post!
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Mark Daniel retweeted
Back at the beginning of the summer when just a couple hundred people were on @ACMomento, we really started to feel like we were onto something when we reached 10,000 Momentos. 1 MILLION Momentos later, we know we are. A HUGE thanks to everyone who's joined the app! 🫡
Over 10,000 Momento's have already been added by just a couple hundred fans on @ACMomento. If you're a sports fan that loves going to games, DM me for early access to the private beta. ⚽️🏀⚾️
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Mark Daniel retweeted
We just flipped the switch on over 500 new football (soccer) leagues and competitions on @ACMomento. Not 5… not 50… 500+ ‼️ This includes Men’s & Women’s Friendlies, and just about everything else you could imagine. Happy Friday 🫡
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"Thiel fellows have achieved shocking success, enough to merit a reconsideration of our current approach to college." bloomberg.com/opinion/articl…
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Mark Daniel retweeted
The Design Miami/ furniture fair has been acquired by e-commerce platform Basic.Space trib.al/wvIbQ8d
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