Mike Cooch

Best way to sandbox an AI is to put it on a Delta flight – it will have no chance of accessing the Internet!

Introducing Omanta (YC S26) the personalized research lab for each patient. Omanta integrates a patient's full medical record, personal genomics, and the latest scientific evidence to understand the molecular drivers of their disease. It maps existing and emerging therapies against their biology. And when the right treatment doesn't exist yet, it launches a personalized campaign to build it. Even the hardest cases rarely have a team dedicated to solving them. Physicians make high-stakes calls with limited time, while data and therapies emerge every week. Science moves fast, but reaching the patient can take years. That's the gap Omanta was built to close. Founders Alfredo Gonzalez, PhD and Ranad Humeidi, PhD spent years on some of the most difficult cancer cases. Alfredo led the personalized therapeutic campaign behind Sid Sijbrandij's complete remission. Together they've worked with leading institutions on personalized vaccines, CAR-T, drug repurposing, expanded access, and continuous molecular monitoring. They've seen what becomes possible when the full force of modern science is organized around one person. They met eight years ago doing early CRISPR cancer research at the Broad Institute of MIT and Harvard. Alfredo Gonzalez (CEO) has a PhD in bioinformatics from UCLA and led research projects across the Broad Institute, UCLA, and Harvard. Ranad Humeidi (CSO) has a PhD in chemical biology from Harvard, and has built and run rare-cancer programs for individual patients when standard options ran out. omanta.com A research lab, for one. Linked-in: bit.ly/omanta-linkedin YC Launch: bit.ly/omanta-yc

Today we're introducing Hark Handoff Handoff has been independently verified as the best internet-use model ever built, outperforming ChatGPT 5.4 & Opus 4.8 While others focus on coding, we focus on everyday life: ordering food, booking flights, shopping, & navigating the web

When I was 22 living in Vegas with my poker buddies we invented a game every time we went out. If you got REJECTED 5 times by girls you got the night FREE. All drinks & food was covered by the other guys. It made getting rejected a positive thing! You approached unattainable girls because you quickly realized there is no BAD RESULT. They say no, who cares, you never see them again & get a point. They say yes, you invite them to join, & have a fun night. Fear of failure & rejection stops 99% of people. This was a fun way to completely remove that fear from our lives!! Highly recommended to young single guys!!

This is an amazing quote from Lindsey Graham about when he realized how politics works. theatlantic.com/ideas/2026/0…

I am officially nominating Donald J. Trump (@realDonaldTrump) for the Nobel Peace Prize. No President in History has ended the same war so many times. Our Dear Leader has ended the war with Iran at least 38 times by CNN’s count. No President has ever done this before. And he is nowhere near finished ending it. It’s a record worthy of the Nobel committee’s recognition. Thank you for your attention to this matter!

The research on afternoon naps is more compelling than most people realize. A 26-minute nap improves cognitive performance by 34% and alertness by 100% according to NASA research on military pilots. The key is staying under 30 minutes to avoid entering slow-wave sleep and waking up groggy. If you cannot nap, 10 minutes of slow nasal breathing in a dim room restores alertness significantly.

We taught two F.03 robots to clean a room and make a bed in under 2 minutes - fully autonomous.

Christopher Nolan asked IMAX to build him a new camera. They did. Then he and Matt Damon spent four months filming The Odyssey on the open ocean, on the largest modern Viking longship in the world, with no green screens at all. The shoot ran 91 days, from late February to August 2025. Seven countries: Morocco, Greece, Italy, Iceland, Scotland, Western Sahara, and Malta. Aside from one indoor studio in Los Angeles, every shot was filmed on real ground. In Italy, the cast and crew climbed 900 feet up a mountain every morning. Imagine walking up a 60-story building before breakfast. In Iceland, they filmed the underworld scenes by lantern light while rain came at them sideways. The four months at sea actually happened at sea. Damon and the actors playing his crew sailed on a real ship called the Draken Harald Hårfagre, used here as a Greek warship. Nolan called the experience "primal." He said the cast and crew were exhausted in a way he had never seen before. The cameras were the other big problem. IMAX cameras have always been too loud to record clean dialogue, which is why directors mostly save them for big action scenes. Nolan asked IMAX to fix this. They engineered a new soundproof case for the camera, a kind of quiet jacket, that lets the lens get within a foot of an actor's face while they whisper and still pick up clean audio. The new cameras also came out lighter and about 30% quieter than the old ones. To prove it worked, the lead cameraman Hoyte van Hoytema filmed a tight close-up of a child reciting a David Bowie song, "Sound and Vision." Nolan watched the test and called it "electrifying." Damon went all-in on the role. He dropped to 167 pounds on a strict no-gluten diet. He grew a real beard for a full year because Nolan refused to allow a fake one. The crew built a full-scale wooden Trojan Horse and shot the attack scene at an ancient walled town in Morocco called Aït Benhaddou. Nolan himself climbed inside the horse with the cast and his cameraman to get the shot. Across the whole shoot they used 2 million feet of film. That comes out to around 380 miles of it, longer than the drive from Los Angeles to San Francisco. At about $1.50 a foot, they spent roughly $3 million just on the film itself. The full budget was $250 million, the biggest of Nolan's career. They wrapped nine days ahead of schedule. Tickets went on sale on July 17, 2025, exactly one year before the movie's release. That had never been done before in cinema history. Half of the 22 US theaters offering IMAX 70mm sold out within 12 hours, bringing in around $1.5 million in a single morning. Nolan called the shoot "an absolute nightmare to film, but in all the right ways." He did not destroy a single IMAX camera. He has wrecked several over his career.

Stripe Atlas just hit 100,000 all-time incorporations. Q1 2026 is +130% Y/Y.

Hello, New York City. 🗽 Over the next week, our electric air taxi will showcase a quieter, cleaner, faster way to move through New York, in partnership with the @PANYNJ, @NYCEDC, and @FAANews. The first ever point-to-point eVTOL flights in New York's history, connecting JFK to Manhattan's heliport network in minutes, demonstrate how we intend to integrate with the region's existing infrastructure. Our vision for New York is simple: make getting to the airport — one of the city's most daunting experiences — one of its best, through partnerships with @Delta and @Uber that connect ground transportation and air travel in a single, seamless journey. Full release + additional photos & videos ⬇️