Eleftheria (Ria) Kodosaki 👩🏻🔬🔬🧠 retweeted
What are the associations between serum estrogen and Alzheimer’s Disease biomarkers?
Analysis of over 800 female participants revealed neither estradiol nor estrone were associated with cerebral spinal fluid Aβ42 #AlzResearch
Full Study: alz-journals.onlinelibrary.w…
Eleftheria (Ria) Kodosaki 👩🏻🔬🔬🧠 retweeted
New UK guidance on Alzheimer's blood tests from @ABNeurologists and @rcpsych
p-tau217 is the test of choice, but only in a specialist assessment when Alzheimer's is already suspected. Not for screening or triage.
Plus a handy tool for clinicians 👇
dementiaresearcher.nihr.ac.u…
Eleftheria (Ria) Kodosaki 👩🏻🔬🔬🧠 retweeted
Inside the UK institute developing an Alzheimer’s disease blood test thetimes.com/uk/healthcare/a…
Eleftheria (Ria) Kodosaki 👩🏻🔬🔬🧠 retweeted
pn.bmj.com/content/practneur… uk guidance on use of blood biomarkers for AD diagnosis Practical Neurology
Eleftheria (Ria) Kodosaki 👩🏻🔬🔬🧠 retweeted
Excited to share our work in @JExpMed led by @t_stevenson95. We show that aggregated α-synuclein at CNS borders drives inflammation and impairs lymphatic function, positioning meningeal immunity as a driver of clearance deficits in Parkinsons disease.
tinyurl.com/5yvpsxhm
Eleftheria (Ria) Kodosaki 👩🏻🔬🔬🧠 retweeted
Mice engineered to overexpress klotho lived 20–30% longer with no signs of illness doi.org/10.1126/science.1112…
Eleftheria (Ria) Kodosaki 👩🏻🔬🔬🧠 retweeted
Exercise biologists! From @atul_deshmukh1 et al
High-resolution, time-resolved proteomics atlas across plasma, saliva & urine from healthy men in response to acute exercise. Exercise regulates >3,000 proteins via distinct, fluid-specific temporal dynamics.
nature.com/articles/s42255-0…
Eleftheria (Ria) Kodosaki 👩🏻🔬🔬🧠 retweeted
Embracing macrophage complexity for research and translation. cell.com/immunity/fulltext/S… @ImmunityCP
Eleftheria (Ria) Kodosaki 👩🏻🔬🔬🧠 retweeted
An aging-sensitive secreted phospholipase confers neuroprotection and cognitive resilience
@NatureNeuro
nature.com/articles/s41593-0…
Eleftheria (Ria) Kodosaki 👩🏻🔬🔬🧠 retweeted
New review in #TRCI- AD heterogeneity and co-pathologies: Defining novel targets, biomarkers, modalities, and research methodologies
Topics:
🧠AD heterogeneity
🧠Co-pathologies and treatment response
🧠Fluid biomarkers
🧠And MORE!
Read the full article: alz-journals.onlinelibrary.w…
Eleftheria (Ria) Kodosaki 👩🏻🔬🔬🧠 retweeted
Long-overdue study of menopause reveals it begins more than a decade before the final period. Uri Alon and collaborators analyze 300 million tests and use a mathematical technique from astronomy to shows HRT can delay many deleterious changes 🧵
Eleftheria (Ria) Kodosaki 👩🏻🔬🔬🧠 retweeted
The histone variant H2A.Z regulates sex differences in Alzheimer’s disease pathophysiology: @NeuroCellPress cell.com/neuron/fulltext/S08…
Eleftheria (Ria) Kodosaki 👩🏻🔬🔬🧠 retweeted
Data from the 90+ Study demonstrate multifactorial resilience #AlzResearch
Key findings demonstrate educational level and pulse pressure impact the association of amyloid burden and global cognition.
Learn More: alz-journals.onlinelibrary.w…
Eleftheria (Ria) Kodosaki 👩🏻🔬🔬🧠 retweeted
Thrilled to share our latest paper @ScienceTM! We found that human microglia clear intraneuronal α-synuclein aggregates by GPNMB-mediated trogocytosis. science.org/doi/10.1126/scit…
Eleftheria (Ria) Kodosaki 👩🏻🔬🔬🧠 retweeted
New in A&D: The impact of chronic stress and social support in cognitive decline #AlzResearch
Higher baseline chronic stress ➡️ greater decline in attention in women & greater memory decline in Hispanic vs non-Hispanic participants
Learn more: alz-journals.onlinelibrary.w…
Eleftheria (Ria) Kodosaki 👩🏻🔬🔬🧠 retweeted
In the new @ScienceMagazine special issue on women's health, a 5★ review of menopause hormone therapy to promote healthy aging
science.org/doi/10.1126/scie…
Eleftheria (Ria) Kodosaki 👩🏻🔬🔬🧠 retweeted
A map of fats across the whole mouse brain reveals a spatial architecture that differs from that seen in gene-expression and protein atlases
go.nature.com/3VQvDS7
Eleftheria (Ria) Kodosaki 👩🏻🔬🔬🧠 retweeted
Prion-like transmission of human tau strains in the mouse brain: nature.com/articles/s41586-0…
Eleftheria (Ria) Kodosaki 👩🏻🔬🔬🧠 retweeted
Super important work🔥 One of the first studies that actually has the power (n=250+ brains) to ask what changes during 'normal' brain aging (no Alzheimer's)
Surprising: Many discoveries we have made 3y ago on aging in brains of mice seem to happen in humans, too. Such as...👇
1) It's not the neurons that seem to be most affected by age! Instead, glia and microglia (the brain's support system) change the most.
2) Microglia launch ~2-3 main expression programs during normal aging: Up-regulation of known microglia aging genes (TSPO, CD22), antigen presentation genes (HLA), signs of an interferon response (IFI44L), induction of 'disease associated' program (GPNMB, SPP1, etc)
A paper in Nature presents the largest-known map of gene expression in the human prefrontal cortex region of the brain. go.nature.com/4yLUu82
ALT This is figure 1, which shows single-nucleus transcriptomic atlas of the human DLPFC across the lifespan.