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Mike Weale (@mikeweale) profile picture

Mike Weale

@mikeweale

Statistical Geneticist at Genomics plc, using genetics to unlock precision health

Joined December 2013
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Proud to have been a part of this work, illustrating the clinical benefits of PRS-guided screening
Genomics (@Genomicsltd) profile pictureGenomics@GenomicsltdFeb 6
1/10 We’re excited to announce the publication of our work with @StanfordMed, examining the premature deaths that would be saved if PRS-guided screening was introduced across seven common disease screening programs nature.com/articles/s41467-0…
Image from Genomics (@Genomicsltd)
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1/13 Our evaluation of the UK Biobank Polygenic Risk Score (PRS) Release (Version 2, May 2024) is now out in @plosone (doi.org/10.1371/journal.pone…), with @Genomicsplc @uk_biobank @genomicsEngland. The traditional tweetorial/Xorial follows…
A systematic evaluation of the performance and properties of the UK Biobank Polygenic Risk Score...

A systematic evaluation of the performance and properties of the UK Biobank Polygenic Risk Score...

We assess the UK Biobank (UKB) Polygenic Risk Score (PRS) Release, a set of PRSs for 28 diseases and 25 quantitative traits that has been made available on the individuals in UKB, using a unified...

journals.plos.org
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12/13 The UK Biobank PRS Release provides a resource for research into the biological and clinical implications of inherited risk in this world-leading cohort. Version 2 - and future updates - will enable researchers to benefit from the latest advances in polygenic risk scores.
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13/13 Our thanks as ever to the many cohort and GWAS participants and investigators. Co-authors include @Deborah_J_T @DanielJohnWells @SaskiaSelzam @MartaFutema @gil_mcvean @VincentPlagnol @genemodeller @genomicsEngland @Genomicsplc.
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Mike Weale retweeted
Genomics (@Genomicsltd) profile picture
Genomics@Genomicsltd15 Feb 2024
📈Breaking barriers in healthcare! Check out @GenomeWeb's interview with @seamusharrison showcasing the power of genetic risk scores in clinical practice. Learn how it's shaping the future of medicine: genomeweb.com/genetic-resear… #Genetics #Innovation

Genomics Plc Shows Feasibility of Implementing Polygenic Risk Scores in Routine Clinical Care

Cardiovascular risk scores from a common tool and one with a PRS added correlated well with each other, with the added PRS impacting some care decisions.

genomeweb.com
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Proud to have been involved in this important study from Genomics plc
Seamus Harrison (@seamusharrison) profile pictureSeamus Harrison@seamusharrison31 Jan 2024
Exciting news in CVD prevention. Genomics plc and colleagues explore the integration of genetic risk factors into primary care for better heart disease prediction in the NHS. Check out the article here: academic.oup.com/eurjpc/adva… #Genetics
A polygenic risk score added to a QRISK®2 cardiovascular disease risk calculator demonstrated...

A polygenic risk score added to a QRISK®2 cardiovascular disease risk calculator demonstrated...

AbstractAims. The aim of the study was to assess the real-world feasibility, acceptability, and impact of an integrated risk tool for cardiovascular diseas

academic.oup.com
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#RAHChristmas RAH RAH violin, a performance never dialled in!
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Mike Weale retweeted
Genomics (@Genomicsltd) profile picture
Genomics@Genomicsltd24 Oct 2022
We're thrilled to provide the polygenic risk scores for the @ukfuturehealth programme. Together, we will transform the way we detect, prevent and treat many of the most common diseases. ✏️ @smithamundasad @bbchealth @BBCnews bbc.co.uk/news/health-633318…
Health of nation study calls on millions to sign up

Health of nation study calls on millions to sign up

The aim is to uncover better ways to prevent, spot and treat diseases like dementia and cancer.

bbc.co.uk
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Mike Weale retweeted
Genomics (@Genomicsltd) profile picture
Genomics@Genomicsltd10 Oct 2022
We are thrilled to announce our partnership with @ukfuturehealth, using polygenic risk scores to find new ways to prevent, detect, and treat common diseases Read the full story ➡️ genomicsplc.com/news/genomic… #Genomics #PolygenicRiskScore
Image from Genomics (@Genomicsltd)
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75% of my PhD students and many of my post docs work outside academia. In industry, third sector, biotech. I’m proud of every single one. Let’s move on from this insular, echo chamber perspective that universities are the only worthy post-PhD employment 1/2
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