Resident in Internal Medicine and Clinical Immunology - MD-PhD @APHP @InstitutPasteur @criu1149
Paris, France
Joined May 2022
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Marie Robert retweeted
New Research Letter! Anti-Ku positivity in primary #Sjögren's disease is associated with a more severe disease course.
➡️Primary Sjögren’s disease is a common autoimmune disease with systemic manifestations in 40%–60% of patients.
🔗doi.org/10.1111/joim.70169
#autoimmune #AntiKu
Marie Robert retweeted
Anti-Ku antibodies are uncommon—but ILD is not.
In a multicentre study of 154 anti-Ku-positive patients:
🔹 39% developed ILD
🔹 75% showed ILD progression during follow-up
🔹 Male sex predicted faster progression
🔹 Baseline pulmonary fibrosis was associated with worse survival
These findings support systematic ILD screening and long-term monitoring in anti-Ku-positive patients
🔗 rmdopen.bmj.com/content/12/3…
#ILD #Myositis #SystemicSclerosis #AutoimmuneDisease #Rheumatology
Marie Robert retweeted
Maladaptive trained immunity in viral infections
In this Review, Dmitri Sviridov et al. @GWTweets posit maladaptive trained immunity arises from contextual factors and discuss its contribution to system disease and viral vaccine responses.
jci.org/articles/view/192469
Marie Robert retweeted
A 79 y/o man with an 8-month history of VEXAS, with myelodysplastic syndrome, presented with acute-onset fever, bilateral anterior nodular scleritis, and a pustular skin rash. Exam showed large, widespread, non-follicular pustules
Clinical images in A&R
doi.org/10.1002/art.43361
Captions:
Large, widespread, non-follicular pustules were observed (A and B). Skin biopsies from two separate lesions revealed a dense neutrophilic infiltrate in the superficial dermis containing poorly differentiated neutrophils similar to band neutrophils and prominent leukocytoclasia, with no evidence of vasculitis (C, D, and E)
ALT Large, widespread, non-follicular pustules were observed (A and B).
ALT Skin biopsies from two separate lesions revealed a dense neutrophilic infiltrate in the superficial dermis containing poorly differentiated neutrophils similar to band neutrophils and prominent leukocytoclasia, with no evidence of vasculitis (C, D, and E)
Marie Robert retweeted
Anti-ADAMTS13 antibodies trajectory is associated with ADAMTS13 recovery in immune-mediated #TTP
doi.org/10.1002/ajh.70005 #hematology
Marie Robert retweeted
Impaired cytotoxic function and exhausted phenotype of natural killer cells in VEXAS syndrome
Congrats @PBreillat @TerrierBen @KosmiderO ashpublications.org/blood/ar…
Marie Robert retweeted
ICYMI: Chemotaxis as a driver in immune privilege.
O. Thaunat & team dissect the mechanisms of endothelial preservation during cellular rejection and identify mechanisms underlying graft vasculature immune privilege.
jci.org/articles/view/155191
Our paper with @ArthurMageau is out in @AjHematology 🗞️
Close monitoring of anti-ADAMTS13 antibodies titer may guide immunomodulation strategies #iTTP 🩸
Thanks to the wonderful team of CNR MAT 🤝🏼 🇫🇷
onlinelibrary.wiley.com/doi/…
Marie Robert retweeted
🔍 New study: Cluster analysis identifies 3 distinct clinical patterns among patients with systemic autoimmune diseases & anti-Ku antibodies
🫀 Cardiac involvement is common & evolves differently across clusters—highlighting need for vigilant follow-up
👉rmdopen.bmj.com/content/11/2…
Marie Robert retweeted
NEW RESEARCH for #LUPUS2025—Maternal autoantibodies to the sodium potassium pump α1 subunit AT1A1 and fetal autoimmune congenital heart block: a case-control study bit.ly/43lRzol
Plus, linked Comment bit.ly/3STJLoV
Marie Robert retweeted
Chilblains were reported in #SARSCoV2–exposed individuals without PCR- or serologically defined #COVID19. Saidoune, Gilliet, @AhmadYatim_ et al. show that excessive TLR7 responses to SARS-CoV-2 by pDCs are linked to I-IFN–driven chilblain development. hubs.la/Q03hcY8_0
Marie Robert retweeted
#NewNProt: Protocol Extension describing joint spatially resolved epigenomic and transcriptomic profiling on a tissue section using #microfluidic chips bit.ly/4hLs7xT #spatialtranscriptomics #spatialepigenomics see also associated News&Views
Marie Robert retweeted
Five years after the first description by our group and others of SOCS1 insufficiency as a new cause of monogenic immune dysregulatory disorder, we are very pleased to share this international cohort of patients just published in @TheLancetRheum
thelancet.com/journals/lanrh…
Marie Robert retweeted
Trained immunity in chronic inflammatory diseases and cancer bit.ly/4jCG2IK
Marie Robert retweeted
.@Clemence_Dvd et al. @crow_lab suggest that UNC93B1 mutations cause monogenic systemic #lupus erythematosus or chilblain lupus due to differentially enhanced TLR7 and TLR8 signaling. hubs.la/Q033w5Y-0
📘 In our #Immunology update collection: hubs.la/Q033vWth0
See our Comment on: Inflammatory plasma protein levels are elevated years before sarcoidosis diagnosis 🇸🇪🇫🇷 thanks to Etienne Villain @NaderYatim @ArthurMageau @RaphaelBorie @nathanpsmad @darragh_duffy and all co-authors
publications.ersnet.org/cont…
Marie Robert retweeted
Nonischemic cardiac involvement in VEXAS syndrome is rare, primarily pericarditis, myocarditis, and heart vasculopathy; these are directly linked with VEXAS’s systemic inflammation. ja.ma/3VBtNBJ @mimrobert @TerrierBen @mekinian2 @RimBourguiba1 @SophieGeorgin
💙🤍♥️
Le 13-Novembre est gravé dans nos mémoires en lettres de douleur.
Le Bataclan, les terrasses, le Stade de France. Paris, Saint-Denis. La France. Marqués à jamais par l’effroi.
Les victimes, les familles, ceux qui ont tout donné pour préserver la vie, à jamais dans nos cœurs.
Ce soir de 2015 et les jours qui ont suivi, face à l’horreur et à la haine, notre courage a redoublé.
Toujours, nos valeurs et notre unité sont demeurées inébranlables.
Nous n’oublierons jamais.