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“...Time is the fire in which we burn.” -Delmore Schwartz
🪡 🧵 thread about #lactate oxidation and metabolic heat 🔥. /1
frontiersin.org/articles/10.…
Daniel Kane retweeted
Wonderful to have played a small role in this effort. This century of biochemistry will place the staggering numeracy in the systems we study at the forefront of our science. Looking forward to more thinking like this👏 #Biochemistry #Redox #Bioenergetics
Pleasure to collaborate with @PanosChatz1 and @CAS_ReproLab on this work dealing with the i-space a proteoform centric theory of redox regulation sciencedirect.com/science/ar…
Daniel Kane retweeted
Here's the link to the paper. Download in the next 50 days for free! @ECU_Biology @ECUResearch @EastCarolinaDOI authors.elsevier.com/c/1iFnL…
Daniel Kane retweeted
New publication from my lab about the metabolic (mitochondrial) effects of Yerba Mate (YM). We found disparate effects of YM in fat tissue and muscle tissue. In fat, YM increased metabolic rate (via greater mitochondrial uncoupling). However, in muscle, YM had no such effect--mitochondria were as efficient as ever. Overall, a uniquely beneficial series of changes that helps explain the general observations of YM facilitating weight loss and exercise performance. @dan_hues @Unicity mdpi.com/2072-6643/15/20/445…
Daniel Kane retweeted
Since the discovery of CRISPR-Cas systems, people have wondered if a similar type of system exists in eukaryotes. Today, we report in @Nature the characterization of Fanzor, a eukaryotic RNA-guided system that can be reprogrammed for human genome editing. nature.com/articles/s41586-0…
🔥thread alert: origins of the Crabtree effect
Time for summer fun 🌞⛱️: let's talk about the Crabtree effect 🦀🦀, an ultimate #metabolismclassic, describing the ability of glucose to represses mitochondrial respiration ncbi.nlm.nih.gov/pmc/article… 1/n
The pyruvate dehydrogenase complex: Life’s essential, vulnerable and druggable energy homeostat.
By P.W. Stacpoole and C.E. McCall.
2023.
🔥
pubmed.ncbi.nlm.nih.gov/3686…
“In conclusion, lactate is less effective than glucose and potentially detrimental during neural network rhythms featuring high energetic costs, likely through the lack of some obligatory ATP synthesis by aerobic glycolysis at excitatory and inhibitory synapses.”
Lactate as a supplemental fuel for synaptic transmission and neuronal network oscillations: Potentials and limitations - PubMed pubmed.ncbi.nlm.nih.gov/3730…
Daniel Kane retweeted
Excited to announce our group's latest preprint led by @IlyaNBoykov + @Mcmontgomery11
biorxiv.org/content/10.1101/…
In it we compared OXPHOS expression/function, across various murine tumor types, matched normal tissues and other organs -- all normalized to mito content.
🧵below
A mechanistic link between the hyperglycemia of T2D and Alzheimer’s Disease involving KATP channels 👇
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Otto Warburg (of the “Warburg effect”) features prominently in Bound by Muscle as a mentor to Meyerhof.
More about this in recently published book, Bound by Muscle: Biological Science, Humanism, and the Lives of A. V. Hill and Otto Meyerhof g.co/kgs/fTXXU5
The periodic table of elements came to Mendeleev in a dream?! themarginalian.org/2016/02/0…
“An important, unresolved issue in these studies is that the carbohydrate taken up in excess of oxygen during exhaustive exercise does not accumulate in brain (2)...” – G. Dienal, 2019 (1)
1. pubmed.ncbi.nlm.nih.gov/3056…
2. pubmed.ncbi.nlm.nih.gov/1865…
The ⬇️ in 🧠 O2/[glucose+0.5lactate] with exerc has been interpreted to reflect declining complete oxidation but not accumulation of glucose and lactate taken up by the 🧠. /20
ncbi.nlm.nih.gov/pmc/article…
More on this from Brooks: sciencedirect.com/science/ar…
And a podcast: foundmyfitness.com/episodes/…
This view was revised for mammalian metabolism vis-a-vis @GeorgeABrooks3’s Lactate Shuttle model. First conceived by Brooks (1985), a central tenet of the model was that lactate travels within and between cells as an oxidizable fuel /7
link.springer.com/chapter/10…
“Lactate is the universally available form of carbohydrate” - J. Rabinowitz, 2022
👆More about this in podcast form: peterattiamd.com/joshrabinow… The important role of #lactate as an alternate fuel begins around 36:30.
While research has increasingly confirmed Brooks’ model and the centrality of lactate metabolism (e.g., pubmed.ncbi.nlm.nih.gov/2904… @realTonyHui), work on the physical bioenergetics of lactate metabolism has been relatively sparse since the time of Hill & Meyerhof. /8
More about this in recently published book, Bound by Muscle: Biological Science, Humanism, and the Lives of A. V. Hill and Otto Meyerhof g.co/kgs/fTXXU5
Shout out to collab’s Alex Foo, Erin Noftall, Karen Brebner, and @gmsprezman
And to the helpful reviewers, one of whom (revealed later to be THE Lee Hansen) provided exceptional feedback and guidance.
✌️/fin