@mkuchroo

Internal Medicine Resident @MGHMedicine | MD PhD @YaleMed

Joined May 2013
  • Tweets23
  • Following127
  • Followers139
Excited to have our article "Trellis tree-based analysis reveals stromal regulation of patient-derived organoid drug responses," out in @CellCellPress today!! Great collaboration with @christophertape lead by @Maria_Ramos_Z and @AlexanderTong7! authors.elsevier.com/sd/arti…
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(1/n) Happy to share our work Time-Inhomogeneous Diffusion Geometry and Topology, published in the SIAM journal on the Mathematics of Data Science (SIMODS) ! epubs.siam.org/doi/abs/10.11… – at Berne, Switzerland

Time-Inhomogeneous Diffusion Geometry and Topology | SIAM Journal on Mathematics of Data Science

Abstract. Diffusion condensation is a dynamic process that yields a sequence of multiscale data representations that aim to encode meaningful abstractions. It has proven effective for manifold...

epubs.siam.org
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(1/n) We are excited to present a new multiscale data exploration tool called CATCH to identify signatures of immune activation in the first single cell atlas of human retinas affected by age-related macular degeneration (AMD) nature.com/articles/s41467-0… – at Madison Center, CT
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(1/n) Today I'm proud to present our work on learning dynamics in cancer using neural ODEs and optimal transport! biorxiv.org/content/10.1101/…

Learning transcriptional and regulatory dynamics driving cancer cell plasticity using neural...

While single-cell technologies have allowed scientists to characterize cell states that emerge during cancer progression through temporal sampling, connecting these samples over time and inferring...

biorxiv.org
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Spotted - Malcolm Gladwell in Miami with @mkuchroo . Thought of asking him if 10000 hrs of abuse as a resident would make me a better doctor & human but worried that was too spicy for our 1st meeting so settled for this pic instead #medtwitter #malcolmgladwell #imresidency
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Grateful for the privilege to pump/breastfeed but incredibly saddened for other mamas by empty formula shelves in stores SO many months after the #formulashortage began - @USSupremeCourt @WhiteHouse how about you help us feed our children instead of taking our rights away? – at Brookline, MA
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Incredible week of Harvard commencements for classes of 2020-2022 - officially Juhi R. Kuchroo MD PhD and Karan Ganjawalla MD DMD! @KuchrooLab @mkuchroo @HarvardMITmdphd
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We made the cover!! Check out multiscale phate in this issue!!
Nature Biotechnology
@NatureBiotech16 May 2022
The May issue is live nature.com/nbt/volumes/40/is… On our cover, disease signatures in high-dimensional biomedical data are detected with a visualization algorithm go.nature.com/3K0QCqi
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Female scientists at NYU feel utterly betrayed today, myself included. Where does Title IX start and end? If you’re willing to support the women at NYU, we would appreciate if this were spread far and wide. #WomenInScience #WomenInSTEM @NIH @HHMINEWS #Cancer #Science
News from Science
@NewsfromScience25 Apr 2022
Biologist David Sabatini, who has been forced out of or fired from three leading institutions for sexual misconduct, may now be hired by the New York University Grossman School of Medicine. fcld.ly/m23kyhr

NYU may hire biologist pushed out of MIT, Whitehead for sexual misconduct

David Sabatini, forced out of three institutions, appears to have support from NYU medical school dean and a New York billionaire philanthropist

science.org
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I would like everyone in science to read the painful, poignant description of what, exactly, Sabatini did to women under his mentorship. It should make you sick to your stomach. I don't think I could still be in science if I'd faced any of this. docdroid.net/IbuM7VK/searchp…

search.page.3.pdf

13 COMMONWEALTH OF MASSACHUSETTS MIDDLESEX, ss. SUPERIOR COURT DEPARTMENT OF THE TRIAL COURT Civil Action No. 21CV02828. __________________________________________ DR. DAVID M. SABATINI, ) ) Plaint...

docdroid.net
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NBC news coverage of @VirusesImmunity and I speaking about the project nbcconnecticut.com/news/coro…

Researchers at Yale Find Scientific Way to Predict Outcomes of COVID-19 in Patients

Since COVID-19 hit our state two years ago, more than 10,000 residents have died, but what if there was a scientific way to predict who would live and who would die? A team of researchers at Yale...

nbcconnecticut.com
Nature Biotechnology
@NatureBiotech28 Feb 2022
Multiscale PHATE identifies multimodal signatures of COVID-19 go.nature.com/3K0QCqi
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1/5 Check out SCAVENGE, led by @fulong_yu in the Sankaran Lab (@bloodgenes) - a new method which maps causal variants to their relevant cellular context using single-cell epigenomic data: biorxiv.org/content/10.1101/…
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Excited to have our work on Multiscale PHATE, COVID19 with @VirusesImmunity, @fperrywilson, Yale Impact, @Mila_Quebec, @mrguywolf out in @NatureBiotech! Spearheaded by @mkuchroo, @JcsHuang and Patrick Wong. We explore 54 million cells to find features predictive of mortality.
Nature Biotechnology
@NatureBiotech28 Feb 2022
Multiscale PHATE identifies multimodal signatures of COVID-19 go.nature.com/3K0QCqi
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Proud to announce the dissertation defense @mkuchroo, who has worked on amazing projects involving coarse graining of data, visualization and multimodal data integration. DM me for zoom link!
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Hey everyone! I recently started writing for @Medium and just published my first article in their @TDataScience publication! I write about an innovative data visualization algorithm my lab uses frequently called PHATE from the @KrishnaswamyLab. towardsdatascience.com/why-y…

Why you should be using PHATE for dimensionality reduction

An intuitive and effective way to visualize the beauty and complexity of your data

towardsdatascience.com
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Manik Kuchroo retweeted
Kuchroo Lab@KuchrooLab3 Jul 2021
New work from our lab and @YosefLab just out in @CellCellPress. A wonderful collaborative effort spearheaded by @DrChaoWang1 and Allon Wagner. We developed and validated a computational algorithm to decipher metabolic networks from transcriptional data! authors.elsevier.com/c/1dL6b…
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Manik Kuchroo retweeted
Karen Dixon@KarenODixon9 Jun 2021
Happy to share our recent work on the role of Tim-3 on Dendritic cells in Cancer! Huge thanks to all involved especially my mentor maximus Vijay @KuchrooLab. nature.com/articles/s41586-0… @BrighamResearch @BWHNeurology @broadinstitute @Nature
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Our lab, along with @YaleGenetics @YaleSEAS is excited to bring you the third edition of our Machine Learning for Single Cell Analysis Workshop, totally virtual in January! eventbrite.com/e/machine-lea…
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(1/n) Excited to present collaborative work with @VirusesImmunity @fperrywilson, Yale Impact, @Mila_Quebec, @mrguywolf! We explore 54 million cells, 18 clinical variables from YNHH patients with Multiscale PHATE to find features predictive of outcome. biorxiv.org/content/10.1101/…

Multiscale PHATE Exploration of SARS-CoV-2 Data Reveals Multimodal Signatures of Disease

The biomedical community is producing increasingly high dimensional datasets, integrated from hundreds of patient samples, which current computational techniques struggle to explore. To uncover...

biorxiv.org
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There is some panic and confusion about whether we will ever get an effective #COVID19 vaccine. @RMedzhitov and I discuss immunity that develops after viral infection vs. vaccines, and our outlook on why vaccines are likely to work. (1/n)
New York Times Opinion
@nytopinion31 Jul 2020
Concerns about the staying power of Covid-19 immunity “are confused and mistaken,” write @VirusesImmunity and @RMedzhitov nyti.ms/2Xg7Iue

Opinion | Scared That Covid-19 Immunity Won’t Last? Don’t Be (Published 2020)

Dropping antibody counts aren’t a sign that our immune system is failing against the coronavirus, nor an omen that we can’t develop a viable vaccine.

nytimes.com
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