Natalie Patel (@natzpat) header
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Bay area pathologist with subspeciality interest in #GIpath and #liverpath Tweets ≠ medical advice

Mountainview, CA
Joined September 2015
Photo by Natalie Patel (@natzpat)Photo by Natalie Patel (@natzpat)Photo by Natalie Patel (@natzpat)Photo by Natalie Patel (@natzpat)Photo by Natalie Patel (@natzpat)Photo by Natalie Patel (@natzpat)Photo by Natalie Patel (@natzpat)Photo by Natalie Patel (@natzpat)Photo by Natalie Patel (@natzpat)Photo by Natalie Patel (@natzpat)
Barrett's Esophagus? Basal crypt dysplasia?
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54/M with a 1.3-cm well-circumscribed left paratesticular mass. #gupath #PathTwitter
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#SharkCore biopsy of a pancreatic solid-pseudopapillary neoplasm (SPN) from a 22-year-old female. While beta-catenin is a good marker, LEF1 is much easier to interpret. Corresponding gross specimen was unfortunately large (10 cm) but w/ negative margins. #GIPath #Pathology
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#surgpath🧩time! appendix showing acute appendicitis and this focus: 🔬❓🤔
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Fulminant herpes simplex virus hepatitis
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Easily missed virus- seen in the surface epithelium and some stromal cells in GI tract- Classical appearance of disrupted epithelium with tufting- IP to the rescue! @umiamipathology #pathresidents #pathology #virus @FLPathologists Am J Clin Pathol. 2016;146(5):627-631
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Colonic polyp from known Peutz-Jegher's syndrome. The smooth muscle bundles are splayed, giving an arborising pattern. #GIpath
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Pitfall Alert!!! Seen at the site of bowel perforation.. What do you think #pathtwitter #GIpath ? Signet ring cells?? Pseudo signet ring cells?? Answer in the next tweet...
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Subtle flat IBD-associated dysplasia in a patient with long term UC. In contrast to sporadic colorectal adenomas in which p53 is a late change (not seen in LG TAs), in IBD-dysplasia (and Barrett’s), p53 is aberrantly expressed early in LGD @RogerFeakins @jansen_marnix #GIpath
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Florid case of Mycobacterial avium affecting the colonic mucosa. Apart from the juicy histiocytes, MAC can be seen sneaking in the lamina propria of apparently normal appearing colonic mucosa (pic attached) #PathTwitter #MedTwitter #infections
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Synovial sarcoma of the colon. Another stunning example.
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This colonic tubular adenoma managed to catch cytomegalovirus.
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Eg. of hypermucinous dysplasia in a pt with ulcerative colitis. - Tubulovillous/villous architecture - Hypermucinous, bland cytology - ⬆️risk of HGD/CRC Non-conventional dysplasias are more likely to present as flat lesions & have ⬆️risk of advanced neoplasia #GIpath
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Brilliant! Twitter is alive. Esophageal biopsy - long standing Barrett's. Your diagnosis ladies and gentlemen! And does that P53 stain help? #GIpath
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Haven't posted a case for a while; courtesy of Klaudia Nowak who shared the case with me. Adult with abdominal pain and diarrhoea. @glinglerimek @vi_monappa @DrGeeONE @nusrat_xahra @TristanRutland7 @padmapathology1 @jansen_marnix @GIJamesMD @Vik_deshpandeMD @ariella8 @kriyer68
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A sigmoid colon sessile tumor from a 35-yo woman #pathology #GIpath #gastroenterology #PathTwitter #ImageOfTheDay
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SATB2, ER, and CD10~~~ It's in fact endometriosis!
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-Amyloid in somatostainomas is shown to be distinct - Prosomatostain is converted to two active peptides - somatost 14 & 28 - Post-translation modification (likely loss of S-14) results in formation of aberrant protein PMID 34541974 #GIpath #neuroendocrine #NET
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Dilated appendix with concern for LAMN. No LAMN, but the appendix was distended by thick mucous plug. Careful review of the chart revealed patient had cystic fibrosis(CF)! CF pts can have inspissated mucus in the GI lumen. The excess mucus can plug the appendiceal lumen.
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A Patho-ween story.. You are looking at a bile duct frozen…along creeps a PNI on the edge of the tissue and goes “BOO!” ☺️ #PathTwitter
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