Andrew Li Yim (@ndly91) profile picture

Andrew Li Yim

@ndly91

Bioinformatician. Data scientist.

 Amsterdam
Joined July 2017
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\1 Our new preprint investigates how DNA methylation of circulating monocytes is associated with the presence of CD as well as the presence of CD-activity. Thanks to @enricoferrero and other colleagues at the @amsterdamumc! disq.us/t/3muu8aq
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\4 Taken together, this suggests that the observed differences in methylation might be related to differences the monocyte subsets, which has been observed before (Koch et al. 2010).
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\5 Future Qs: While we have circumstantial evidence that some of the DMGs are differentially expressed among subsets, are they truly differentially methylated? Does an interaction exist between the transcriptome/methylome of the different monocyte subsets and CD(-activity)?
A thread of classifiers learning a decision rule. Dashed line is optimal boundary. Animations with #gganimate by @thomasp85 and @drob. #rstats Logistic regression {stats::glm} with each class having normally distributed features. (1/n)
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Interested in working on multiomics data from thousands of patients in phase III clinical trials? Then join us as a Bioinformatics Scientist working across the Research and Development organizations of Novartis! novartis.com/careers/career-…
Image from Enrico Ferrero (@enricoferrero)
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Excited to see this work now published in @FrontImmunol! We meta-analyse expression profiles of macrophages w/ different stimuli and build a classifier to label disease macrophages according to their activation status frontiersin.org/articles/10.… [1/5]
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Andrew Li Yim retweeted
Stephen Turner (@strnr) profile picture
Stephen Turner@strnr20 Nov 2019
Amazing. There's an R package for identifying and correcting gene names converted to date format by Excel. cran.r-project.org/web/packa… h/t @milothepsychic
Image from Stephen Turner (@strnr)
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Andrew Li Yim retweeted
AnaConesa (@anaconesa) profile picture
AnaConesa@anaconesa5 Nov 2019
Looking for datasets to develop your cool multi-omics integrative analysis method? Check out the @ScientificData Multi-omics Data Collection where six fully linked multi-omics datasets are made accessible. nature.com/collections/hbchc…
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I should have learned how to weld
Image from Andrew Li Yim (@ndly91)
Happy to have this study on bioRxiv where my colleagues and I integrated public datasets on macrophage activation to generate a classification model #elasticnet #immunology #macrophages
Assert Biorxiv (@assert_pub) profile pictureAssert Biorxiv@assert_pub30 Jan 2019
"Defining tissue- and disease-associated macrophages using a transcriptome-based classification model" is the #1 paper on bioRxiv today in immunology. Congrats @enricoferrero. See it at -> assert.pub/biorxiv/immunolog… and assert.pub/papers/532986. Please retweet.
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Our recent integrative analysis of the transcriptome and methylome of gut fibroblasts isolated from Crohn's disease patients is now out on @PLOSONE: journals.plos.org/plosone/ar… #bioinformatics #genomics #immunology
Image from Enrico Ferrero (@enricoferrero)
Image from Enrico Ferrero (@enricoferrero)
Image from Enrico Ferrero (@enricoferrero)
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Sensitive information leakage from functional genomics data: Theoretical quantifications & practical file formats for privacy preservation dlvr.it/QX3LrH
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