Natalia Gumińska (@nemitheasura) profile picture

Natalia Gumińska

@nemitheasura

postdoc at Laboratory of RNA Biology, IIMCB Warsaw, Poland

 Warsaw, Poland
Joined December 2021
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  • Following114
  • Followers23
8 Arabidopsis genotypes, 24 DRS runs, 1 question: what happens to poly(A) tails when 3'-end processing,U1snRNP or m6A is disrupted? Check our new data descriptor in Sci Data: nature.com/articles/s41597-0… #nanopore #polyadenylation #sequencing #ninetails

Arabidopsis nanopore direct RNA sequencing data for mutants in splicing, polyadenylation, and m6A...

Scientific Data - Arabidopsis nanopore direct RNA sequencing data for mutants in splicing, polyadenylation, and m6A methylation

nature.com
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Happy to share another paper published by our lab! It was a great pleasure to be involved in this project! Many thanks to my collaborators, especially Michał Mazur and our PI, prof. Andrzej Dziembowski. nature.com/articles/s42003-0… #nanopore #polyadenylation #RNA #erythropoiesis
Efficient globin production during terminal erythropoiesis in mice depends on the cooperative...

Efficient globin production during terminal erythropoiesis in mice depends on the cooperative...

Communications Biology - In mice, the cytoplasmic poly(A) polymerase TENT5C and RNA-binding protein LARP4B cooperatively protect and re-extend globin mRNA poly(A) tails during terminal...

nature.com
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Hi folks. My software for non-adenosine detection in ONT DRS data is now compatible with pod5 format/Dorado output. Check it out! #ninetails #iimcb #lrb #oxford_nanopore #nanopore github.com/LRB-IIMCB/ninetai…
GitHub - LRB-IIMCB/ninetails: An R package for finding non-adenosine residues in poly(A) tails of...

GitHub - LRB-IIMCB/ninetails: An R package for finding non-adenosine residues in poly(A) tails of...

An R package for finding non-adenosine residues in poly(A) tails of ONT direct RNA sequencing reads - LRB-IIMCB/ninetails

github.com
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Behold! Our new paper in RNA Journal is finally here. This was a highly collaborative work with loads of nanopore data, poly(A) measurements and unexpected results sheding new light on mRNA 3'end processing in brain. Enjoy! rnajournal.cshlp.org/content…
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Natalia Gumińska retweeted
Pawel Krawczyk (@pakraw) profile picture
Pawel Krawczyk@pakraw17 Apr 2025
🎉 Incredibly proud to share my first-author paper in @Nature! Heartfelt thanks to my mentor @AndrzejDziembo1 and the brilliant team at @DziembowskiLab. More details in the 🧵below ⬇️ nature.com/articles/s41586-0…
Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines

Re-adenylation by TENT5A enhances efficacy of SARS-CoV-2 mRNA vaccines

Nature - Upon intramuscular administration, COVID-19 mRNA vaccines are primarily taken up by macrophages, in which the cellular machinery extends their poly(A) tails, thereby increasing mRNA...

nature.com
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Forum Akademickie (@ForumAkad) profile picture
Forum Akademickie@ForumAkad16 Apr 2025
🆕 Nasza droga na łamy @Nature była długa i wyboista. To pierwsza w XXI wieku publikacja w dziedzinie nauk o życiu w tym czasopiśmie wypracowana wyłącznie przez polskie jednostki – mówi o dzisiejszym artykule @AndrzejDziembo1 @IIMCB_Poland forumakademickie.pl/badania/…
Image from Forum Akademickie (@ForumAkad)
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And another work, this time related to excitatory balance in mouse #brain. A fruitful colab with at least 2 papers produced. Hera are #TENT2 mice. researchgate.net/publication…
(PDF) Terminal nucleotidyltransferaseTent2microRNA A-tailing enzyme regulates excitatory/inhibitory...

(PDF) Terminal nucleotidyltransferaseTent2microRNA A-tailing enzyme regulates excitatory/inhibitory...

PDF | One of the posttranscriptional mechanisms regulating the stability of RNA molecules involves the addition of nontemplated nucleotides to their 3′... | Find, read and cite all the research you...

researchgate.net
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I am happy to share our most recent results published in Nature Communications. Ninetails - a pipeline for detection of non-adenosines in poly(A) tails of Oxford Nanopore Direct RNA Sequencing reads. Many thanks to LBR lab members for this work. nature.com/articles/s41467-0…
Direct profiling of non-adenosines in poly(A) tails of endogenous and therapeutic mRNAs with...

Direct profiling of non-adenosines in poly(A) tails of endogenous and therapeutic mRNAs with...

Nature Communications - Ninetails, a neural network that uses Nanopore Direct RNA sequencing data to identify non-A residues in mRNA poly(A) tails is presented. Particularly non-A of therapeutic,...

nature.com
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Let me share with you our latest results describing #polyadenylation in the #rat #brain. The very same results I received #prize at #RNA2024 in Edinburgh. biorxiv.org/content/10.1101/…
The polyadenylation landscape after in vivo long-term potentiation in the rat brain

The polyadenylation landscape after in vivo long-term potentiation in the rat brain

Local protein synthesis in neurons is vital for synaptic plasticity, yet the regulatory mechanisms, particularly cytoplasmic polyadenylation, are not fully understood. This study employed nanopore...

biorxiv.org
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Natalia Gumińska retweeted
bioRxiv (@biorxivpreprint) profile picture
bioRxiv@biorxivpreprint8 Jun 2024
The polyadenylation landscape after in vivo long-term potentiation in the rat brain biorxiv.org/cgi/content/shor… #bioRxiv
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Natalia Gumińska retweeted
bioRxiv (@biorxivpreprint) profile picture
bioRxiv@biorxivpreprint30 Nov 2023
Circular extrachromosomal DNA in Euglena gracilis under normal and stress conditions biorxiv.org/cgi/content/shor… #bioRxiv
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Natalia Gumińska retweeted
Michał Brouze (@mbrouze) profile picture
Michał Brouze@mbrouze15 Dec 2022
My first manuscript, both as a co-author and first author, summarising one of my Phd projects realised in Andrzej Dziembowski lab @IIMCB_Poland, now available as a preprint. biorxiv.org/content/10.1101/…
DIS3L, cytoplasmic exosome catalytic subunit, is essential for development but not cell viability...

DIS3L, cytoplasmic exosome catalytic subunit, is essential for development but not cell viability...

Among numerous enzymes involved in RNA decay, processive exoribonucleases are the most prominent group responsible for the degradation of the entire RNA molecules. The role of mammalian cytoplasmic...

biorxiv.org
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Natalia Gumińska retweeted
Pawel Krawczyk (@pakraw) profile picture
Pawel Krawczyk@pakraw1 Dec 2022
It's my pleasure to share with you are latest preprint demonstrating that #COVID-19 #mRNA #vaccine is re-adenylated in vivo. biorxiv.org/content/10.1101/… @IIMCB_Warsaw 1/n 🧵
SARS-CoV-2 mRNA vaccine is re-adenylated in vivo, enhancing antigen production and immune response

SARS-CoV-2 mRNA vaccine is re-adenylated in vivo, enhancing antigen production and immune response

Though mRNA vaccines against COVID-19 have revolutionized vaccinology and have been administered in billions of doses, we know incredibly little about how mRNA vaccines are metabolized in vivo . Here...

biorxiv.org
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