Neuroscientist | Assistant Professor at Penn | Duke & NTU alum | Exploring brains—biological & artificial | We're hiring!
Philadelphia, PA
Joined July 2014
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Li-Feng Jiang-Xie retweeted
How does the brain track how much sleep has occurred, and gauge the likelihood of waking at each moment? Check out our new preprint: “A molecular integrator of sleep duration and interruption” biorxiv.org/content/10.64898… (1/10)
Li-Feng Jiang-Xie retweeted
How does the striatum help the brain identify what matters? Excited to share our new paper in @NatureNeuro. We show that opposing NAc D1/D2 pathways shape salience representation by regulating amygdalar ACh release, extending D1/D2 MSN models beyond action and reinforcement.
Li-Feng Jiang-Xie retweeted
I'm excited to share that I will be joining the @UBBiology as a TT Assistant Professor, starting in January 2027!
My lab will study the neural circuit mechanisms underlying internal states, with a particular focus on sleep, circuit plasticity, and behavioral regulation.
Li-Feng Jiang-Xie retweeted
Excited to share our latest work with @xiaoxiong2n in @NatureNeuro! 🧠⚡🐭
We uncover how vagus nerve stimulation alleviates pain and modulates pain-related negative affect via a cNTS–PAG–VTA–NAc dopamine circuit.
nature.com/articles/s41593-0…
Li-Feng Jiang-Xie retweeted
I got to spend all day today with Jensen in Taiwan: talking with thousands of engineers and eating street food at a night market. Jensen is received as a rockstar in Taiwan, like it's Beatles in the 60's. It's mind-blowing and fun to watch. But most importantly, through all the interactions and all my conversations with him, he remained the same humble, kind, thoughtful, funny guy he always was, even as a kid who went to these same night markets many years ago.
Btw, we tried a crazy amount of different street food. It's legit some of the most delicious food I've ever had. I can't wait to share video of it, including a ton of our conversations and hangout. When I can pause for a moment from all the travel to edit the video, I'll post it.
Can't wait to continue talking to Jensen and engineers at Computex this week, and exploring more of Taiwan, and of course roaming the night markets for some more delicious street food.
Days like these, even more than usual, I feel like the luckiest kid in the world.
Love you all! ❤️
Li-Feng Jiang-Xie retweeted
Excited to share my first postdoc work co-led with Yuichi Chayama, from @andcyang lab - now out in @CellCellPress! We created a genetic system to trace how the brain clears waste, uncovering surprising new biology about waste clearance pathways. 🧵1/9
🔗 cell.com/cell/fulltext/S0092…
Li-Feng Jiang-Xie retweeted
Congratulations to everyone at Setpoint Medical, present and past, who worked for 18 years to bring a brand new idea for the first time into a clinical reality. This begins a new era for millions of patients needing new options.
businesswire.com/news/home/2…
Li-Feng Jiang-Xie retweeted
Can synapses in the brain switch their signs between excitatory and inhibitory during learning🚦?
Can they act more like weights in artificial neural networks, able to switch signs based on experience 🔃?
Excited to share my thesis work in @blsabatini lab!
🧵 ⬇️ (1/13)
Li-Feng Jiang-Xie retweeted
1/ 🚨 Our new paper is online in @Nature !
As its first author, I’m enthusiastic to finally share it with you all!🎉
🧠 We discovered a mechanistic link between cellular energy metabolism and the control of the need to sleep 💤
👉 nature.com/articles/s41586-0…
@OxfordDPAG 🧵👇
Li-Feng Jiang-Xie retweeted
It’s been a rewarding journey studying sleep as a postdoc, and I’m now exploring faculty positions in neuroscience.
My latest work uncovers a neural circuit mechanism for homeostatic sleep.
Open to opportunities and always happy to chat!
🔗 linkedin.com/in/sang-soo-lee…
Li-Feng Jiang-Xie retweeted
Our review, led by @SamanthaKeilPhD , providing a critical and up-to-date assessment of the role that glymphatic dysfunction plays in the development of clinical Alzheimer's disease, was published in @ScienceMagazine today: science.org/doi/full/10.1126…
Li-Feng Jiang-Xie retweeted
Thank you Jonathan, Mina and Joe for having me on @Morning_Joe to discuss #TheGreatNerve!
Li-Feng Jiang-Xie retweeted
Great progress here in this elegant work revealing new #vagus mechanisms as the basis for future therapeutics. @changsbrain
Dr. Park from the Chang @changsbrain & Tracey lab @KevinJTraceyMD presenting a novel noninvasive model of Red-shifted Optogenic Stimulation of the Inflammatory Reflex 👍🏻 at #Shockcon2025 #proudmentor #FIMR @NorthwellHealth @ShockSociety
Li-Feng Jiang-Xie retweeted
Our new paper with Applied Cognition in @natBME . Using a wearable device that captures different determinants of glymphatic activity to define sleep-related features of glymphatic function in the human brain. nature.com/articles/s41551-0…
My lab at Penn is actively seeking motivated and creative Postdoctoral researchers to join our team. Candidates with strong experience in electrophysiology, imaging, proteomics, or molecular biology are especially encouraged to apply.
med.upenn.edu/jiangxielab/
Li-Feng Jiang-Xie retweeted
How does the brain work?
Scientists are closer to the answer with the largest wiring diagram and functional map of a mammalian brain to date. 🧵
Li-Feng Jiang-Xie retweeted
David Liu wins the Breakthrough Prize in Life Sciences for developing gene-editing technologies, including a "molecular word processor" that can find and replace whole sequences of DNA. His tools are already impacting diseases including cancer. breakthroughprize.org/News/9…
@broadinstitute @HHMINEWS @Harvard
Li-Feng Jiang-Xie retweeted
I'm really excited to introduce our new paper @DulacLab on the neurobiological original of "sociality" (the need of being together), recently published in Nature (see detailed digest below).
nature.com/articles/s41586-0…
My lab at Penn is hiring at all levels! We have posted a Research Specialist position on Careers@Penn (link below), and we are also actively looking for postdocs and graduate students. If you're interested in the science of sleep and neurodegeneration, please consider joining us!
wd1.myworkdaysite.com/recrui…
I sincerely thank everyone for your interest in my lab. I also want to apologize if I was unable to reply to your messages in a timely manner. For the Research Specialist position, please apply through the link. Postdoc candidates and current Penn students are welcome to contact me. Prospective students can apply through our amazing Neuroscience Graduate Group program. Thank you all again!
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