Nick Light (@nick_light) header
Nick Light (@nick_light) profile picture

Nick Light

@nick_light

Medicine, genomics, science, NBA (Raptors), running, PGY4 in Medical Oncology at @UofT_DOM, MD/PhD @UofTMDPhD (He/him)

 Toronto, Ontario
Joined February 2019
  • Tweets134
  • Following316
  • Followers285
7Media
Photo by Nick Light (@nick_light)Photo by Nick Light (@nick_light)Photo by Nick Light (@nick_light)Photo by Nick Light (@nick_light)Photo by Nick Light (@nick_light)Photo by Nick Light (@nick_light)Photo by Nick Light (@nick_light)
✨Check out our study✨We use germline genetic and epigenetic data to identify diagnostic biomarkers, prognostic signatures, actionable therapeutic targets and correlates of clinical heterogeneity that will allow for improved clinical management of LFS patients!
Cancer Research Communications (@CRC_AACR) profile pictureCancer Research Communications@CRC_AACR4 Apr 2023
Just published— Multiple germline events contribute to cancer development in patients with #LiFraumenisyndrome, by @vallisubasri et al. bit.ly/3U5KG5L @UofT @sickkids #openaccess
Image from Cancer Research Communications (@CRC_AACR)
2
4
16
2,364
Amazing work by @vallisubasri comprehensively investigating the ways in which germline genetic variants and epimutations effect cancer risk in patients with Li-Fraumeni syndrome, using whole genome sequencing and methylation data from 396 LFS patients.
Valli Subasri (@vallisubasri) profile pictureValli Subasri@vallisubasri3 Apr 2023
Multiple germline events contribute to cancer development in patients with Li-Fraumeni syndrome aacrjournals.org/cancerresco…
2
2
8
1,514
@vallisubasri used this to develop a machine learning model which can predict cancer risk in patients with Li Fraumeni Syndrome.
1
1
294
In the future this holistic approach could be used to develop tailored strategies for cancer surveillance in patients with this rare and devastating cancer predisposition syndrome.
2
239
Happy to share our preview on the spatial organization of microbiota in cancer published in @ImmunityCP. Original paper by: @CJohnstonLab1 @BullmanLab @fredhutch cell.com/immunity/fulltext/S…
Putting bacteria on the cancer map

Putting bacteria on the cancer map

In a study recently in Nature, Galeano Niño et al. use spatial profiling and single-cell RNA sequencing to delineate the spatial organization of microbiota in cancer. Their findings demonstrate that...

cell.com
3
9
26
5,570
Our study is out today in @NatureComms ! We analyzed cancer genomes from patients with Li-Fraumeni syndrome and found early copy number gain of the mutant allele of TP53 to be a characteristic feature of these tumours. nature.com/articles/s41467-0…
Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis

Germline TP53 mutations undergo copy number gain years prior to tumor diagnosis

Nature Communications - Li-Fraumeni syndrome (LFS) is associated with pathogenic germline TP53 variants and predisposes patients to cancer; understanding the evolution and drivers of LFS-related...

nature.com
6
28
4
97
18,784
Amazing to watch this study grow over the past 7+ years. Congrats to the entire KiCS program!
Nature Cancer (@NatureCancer) profile pictureNature Cancer@NatureCancer2 Jan 2023
💫ONLINE NOW @NatureCancer – „The clinical utility of integrative genomics in childhood cancer extends beyond targetable mutations” by #DavidMalkin #AdamShlien & Co. 👇 nature.com/articles/s43018-0… nature.com/articles/s43018-0…
2
9
1,691
Who else thinks that instead of wasting millions of tax dollars on private, for-profit agencies to provide hospitals with temporary nurses...the Ontario government should just provide ALL nurses with proper wages, permanent jobs & benefits? ✋🏾
266
1,145
109
6,422
Congrats @cd_steele and @NischalanP ! Glad to have made a small contribution to this foundational work!
Christopher Steele (@cd_steele) profile pictureChristopher Steele@cd_steele16 Jun 2022
We have expanded our previous method of copy number signatures developed in sarcomas to identify a reference set of pan-cancer copy number signatures. These are available on @cosmic_sanger now! 1/2 nature.com/articles/s41586-0…
Signatures of copy number alterations in human cancer

Signatures of copy number alterations in human cancer

Nature - A new framework enables a pan-cancer reference set of copy number signatures derived from allele-specific profiles from different experimental assays.

nature.com
4
Congratulations again to all of our 2022 MD/PhD Graduates: @AlainnaJJ, @nick_light, @skzahr, @TinaMarvasti, @ben_ouyang, @ayesh_sen & @ax_lozano 🎓🩺 #UofTGrad22 Alongside them are our Director, Dr. Nicola Jones (@NicolaJGI), and our Program Manager, Kendra Hawke 🤩
Image from Students of U of T's MD–PhD Program (@uoftmdphd)
Students of U of T's MD–PhD Program (@uoftmdphd) profile pictureStudents of U of T's MD–PhD Program@uoftmdphd14 Jun 2022
Today we celebrate a MAJOR milestone achieved by our MD/PhD students (@uoftmedicine @UofTMDprogram)! They have completed 8 yrs of training and are moving onto residency! Below is a thread sharing their wisdom from their time in the MD/PhD program 👩🏾‍🎓👩🏾‍🔬👩🏾‍⚕️
1
7
72
Congrats @andygxzeng! Amazing study characterizing and stratifying the stem cell hierarchy in >1000 AML patients into 4 major classes, with distinct biology, clinical outcomes and drug sensitivity @uoftmdphd
Andy Zeng (@andygxzeng) profile pictureAndy Zeng@andygxzeng26 May 2022
Super excited to share that our study on cellular hierarchies in acute myeloid leukemia has been released today in @NatureMedicine! nature.com/articles/s41591-0… A short tweetorial below: /1
2
13
Nick Light retweeted
Eric Topol (@EricTopol) profile picture
Eric Topol
@EricTopol12 May 2022
This week @TheLancet's cover
Image from Eric Topol (@EricTopol)
165
3,394
283
9,474
Incredibly thankful for the opportunity to train in Internal Medicine at UofT! Grateful for my 8 years @uoftmdphd and over the moon to be continuing my training here. I cannot thank enough all the amazing people who have supported me through this process. Excited to get to work!
Image from Nick Light (@nick_light)
14
4
1
211
My Dad and his friend just released their new book on life in Paris in the 70s, and its already got great reviews! "Both authors skillfully build on each other’s recollections to bring a vanished world to vibrant life" @KirkusReviews All royalties go to the @RedCrossUkraine🇺🇦
Image from Nick Light (@nick_light)
1
2
1
7
It's now available on amazon: amazon.ca/dp/B09W73Y1BP
Image from Nick Light (@nick_light)
5
Yay! Our review is paper out!!🤓🥳🕺💃🕺💃 Hope it is useful for the community! #MutationalSignatures : Emerging concepts, caveats and clinical applications Access it here: rdcu.be/cp5t9 🙌 @GeneChChKoh @_ADegasperi @xueqing_zou @SophieMomen
Image from Serena Nik-Zainal (@SerenaNikZainal)
10
89
2
321
Congrats @nathanielDA_PhD ! A massive advance in our understanding of leiomyosarcoma, pointing to a new therapeutic option for these patients.
Nathaniel D Anderson (@natedandy_PhD) profile pictureNathaniel D Anderson@natedandy_PhD24 Jul 2021
Our paper (from my PhD at @SickKidsNews) describing the mutational processes of primary and metastatic #leiomyosarcoma is out now in @NatureComms. Check it out here 👉🏽: rdcu.be/cpLue
Image from Nathaniel D Anderson (@natedandy_PhD)
1
5
Today is International Li-Fraumeni Syndrome Awareness Day, co-sponsored by the @theNCI‘s Division of Cancer Epidemiology and Genetics! As we fight for knowledge and treatment for LFS for all, use today to share your story and help us spread the word about LFS. #LFSAwarenessDay
1
2
2
4
Incredible. Uncanny. Unnerving. Also, kind of loveable.
Carole Cadwalladr (@carolecadwalla) profile pictureCarole Cadwalladr
@carolecadwalla29 Dec 2020
I went to a DARPA robotics challenge in 2015 & the robots could barely walk in a line without falling over. And now...
7
I have a joke about sequence variants but I always make a typo in the punchlinee
This Post is from an account that no longer exists. Learn more
6
Load more