@nlweilinger

Postdoc in Neuroscience at UBC

 Vancouver, British Columbia
Joined May 2018
  • Tweets50
  • Following411
  • Followers154
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Our paper is out! nature.com/articles/s41467-0… With genetic Ca2+ clamping and chemogenetic activation of astrocytes, we show that astrocytes enhance neurovascular coupling when neuronal activation is sustained but not when activation is brief.
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Nick Weilinger retweeted
Katalin Toth@mossy_fibers11 Nov 2022
This is such a shocking graph. 🇨🇦 is falling behind in science, already existing investments lose their value due to diminishing support for science, our best trainees won’t return after their postdocs. Canada urgently needs long-term vision and plan for science
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Check out our new paper in @CellReports where we image pathological chloride microdomains and swelling in dendrites using FLIM. cell.com/cell-reports/fullte…

KCC2 drives chloride microdomain formation in dendritic blebbing

Neuropathological dendritic swelling and blebbing are shown by Weilinger et al. to be triggered by pathological, non-uniform [Cl–]i accumulation driven by NMDAR overstimulation and Ca2+ entry that...

cell.com
Brian macvicar@brian_macvicar25 Oct 2022
j.celrep.2022.111556 Alert- How do neurons swell and die? A surprising twist in Cl- dysregulation in dendritic blebs from KCC2 reversal!
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Do microglia generate oxidative stress in Alzheimer’s? Apparently not! Shown in this paper by Stefan Wendt and my lab microglia are protective and lysosome dysfunction seems to be key. doi.org/10.1016/j.redox.2022…
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Nick Weilinger retweeted
Tim Murphy@vangreenmouse21 Apr 2022
Postdoctoral position available in Tim Murphy's Lab at the University of British Columbia, Brain Circuits mediating Recovery After Stroke and also Mouse Social Interaction. Please send CV to Tim Murphy [email protected] murphylab.med.ubc.ca/ please re-tweet
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Nick Weilinger retweeted
CAN ACN@CAN_ACN27 Apr 2021
We encourage all MPs to support M-38 today, to create a dedicated @HoCCommittees on Science & Research - to embed science in our democratic institution + provide a way for scientists to engage with our gov. Thank you @KirstyDuncanMP for proposing this!
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Depressing quote from the article below: "...Canada’s current expenditures on science that are by far the lowest in the G7. Over the decades, the CIHR budget has dropped from approximately 10 percent to now barely two percent of the U.S. NIH budget." universityaffairs.ca/opinion…
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Lots of exciting new data out there showing metabolism regulates microglia in the brain! Read all about it in our new review in @TrendsNeuro! sciencedirect.com/science/ar…
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Nick Weilinger retweeted
Eli York@elimyork18 Sep 2020
Turns out metabolism controls more than just energy production! Check out our new paper showing microglial metabolism controls cytokine release - and neuronal communication! Great work, Jingfei Zhang, @HyunBChoi, and @brian_macvicar dx.doi.org/10.1002/glia.2391…
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Make sure to join us when we go live in 30 minutes to learn more about #COVID19 R&D! WATCH LIVE: ow.ly/NHUG50zMBpx Have a question for the Panelists? Comment below and we'll answer it live! #science #research
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Microglia are the immune cells of the brain, so it's important for them to function in any environment. New research from @brian_macvicar lab shows they can still do their job even when there's no glucose around! Check out their findings in @NatureComms go.nature.com/2xrVjcU
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Congratulations to my colleagues @LPBernier and @elimyork on their latest publication! Happy to be a part of it 👍
Louis-Philippe Bernier@LPBernier25 Mar 2020
Proud to share our work on the unique metabolic flexibility of microglia in the brain! These microglia won’t stop working, even without glucose! nature.com/articles/s41467-0…

Microglial metabolic flexibility supports immune surveillance of the brain parenchyma

Nature Communications - Glucose is the main source of fuel in the brain. Here, the authors show that in the absence of glucose, glutamine is required for microglia to maintain their immune...

nature.com
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Same Celebration with Nick and Ali just joining us after working hard in the lab.
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Congratulations to my PhD supervisor and friend, @neurophy! Very exciting day!
Roger Thompson@neurophy23 Jan 2020
Yesterday in the span of 10 minutes I received word that my @CIHR_IRSC project grants were funded and the work of @JennyBialecki and others made the cover of @SfNJournals. #surreal Congrats to @nlweilinger for amazing cover art!
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Nick Weilinger retweeted
Matt Hill@canna_brain11 Dec 2019
At long last, the elegant work from @neurophy on how pannexin-1 channels regulate synaptic anandamide actions at TRPV1 receptors to gate glutamate release is out in @SfNJournals. Congrats to @JennyBialecki @nlweilinger @haleyv and everyone else involved! jneurosci.org/content/early/…
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A new elementary school in Calgary will be named after #SKResearch Scientist Dr. Freda Miller for her outstanding contributions in cell and molecular developmental neurobiology. Congratulations Dr. Miller! #WomeninSTEM calgaryherald.com/news/local…

New elementary school in Calgary named after scientist

calgaryherald.com
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Optimists who reduce stress in their lives may enjoy “extraordinary longevity”, that is, live past 85. Dr. Jaideep Bains & colleagues in his @stressynomics lab study how neural circuits in our brains respond to & adapt for stress, & its contagious nature. bit.ly/2m2MaS5
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This was a fun intra-lab collaboration with @elimyork and @JeffLeDue that should serve as a cautionary tale if you're considering imaging NADH-FLIM in GFP-expressing cells.
Eli York@elimyork6 Aug 2019
Excited to share a recent paper with @nlweilinger, @JeffLeDue, and @brian_macvicar showing how GFP affects metabolic lifetime imaging of NAD(P)H. doi.org/10.1364/BOE.10.00438…
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Congratulations Eli! Very impressive defense. It was a pleasure to watch and a well deserved outcome!
Brian macvicar@brian_macvicar17 Jun 2019
Congratulations to the amazing Eli York who just passed her PHD exam with flying colors. What a wonderful student and colleague!! Presenting Dr. York!
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