Research Scientist - Work interests mostly related to the simulation of biomolecular systems - Graças a Deus nasci na América Latina 🇧🇷
United States
Joined December 2010
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🚀 Making it Rain ☁️💦 just got an AI-powered upgrade!
First, we made MD simulations rain down from the cloud. Now, we’re bringing deep learning into the mix! 🌩️🤖
Pablo Arantes - @pabloarantes.bsky.social retweeted
Ontem começou a derrocada da extrema-direita mundial.
Amanhã Netanyahu vai perder as eleições em Israel.
Terça que vem Trump vai perder a maioria no Congresso.
Ano que vem será a Argentina, depois vamos ganhar a França. Os povos do mundo vão aprender com o Brasil como derrotar os seus fascistas.
E aos poucos o fascismo vai se tornando mais uma vez uma mancha na História.
Pablo Arantes - @pabloarantes.bsky.social retweeted
É amanhã que você evitar que o Brasil, admirado por todo mundo, seja uma VERGONHA internacional, um MICO mundial, elegendo um GÂNGSTER apoiador de assassinos, sicários, milicianos, falsarios, golpistas, coaches e entreguistas.
Pablo Arantes - @pabloarantes.bsky.social retweeted
Que fala forte da Mônica Waldvogel na GloboNews sobre o sucesso das manifestações de Lula neste segundo turno!
“Tem essa emoção de ser o último ciclo eleitoral de Lula, como também o medo e o temor de que Flávio Bolsonaro não tem as credenciais democráticas necessárias para o nosso futuro próximo. E isso não é à toa, é porque passamos pelo governo Jair Bolsonaro, que culmina com uma tentativa de golpe. Embora a manifestação petista seja alegre, tem uma angústia, um temor de que não apenas o ciclo de Lula esteja se encerrando, mas um ciclo da democracia tal como conhecíamos.”
Pablo Arantes - @pabloarantes.bsky.social retweeted
Acertei que Flávio ultrapassaria Lula nas pesquisas , depois acertei que Flávio terminaria na frente , agora estava falando igual um papagaio tem duas semanas que nós íamos empatar entre quarta e quinta feira e ninguém me ouvia! Agora espero que acreditem em mim! Está sendo gerada uma onda e o ápice dela será no domingo! Uma onda que vai varrer a extrema direita do país, que fará com que o mundo inteiro veja no Brasil o último bastião da democracia no mundo , e que reelegerá LUIZ INÁCIO LULA DA SILVA presidente do Brasil!
Pablo Arantes - @pabloarantes.bsky.social retweeted
Public preview of BioEmu2! @MSFTResearch AI for Science’s new foundation model for biomolecular structure, dynamics and function. Open weights, MIT license.
github.com/microsoft/bioemu2
Movie: BioEmu2-simulated binding of intrinsically disordered peptide PUMA to MCL-1 receptor. 🧵⬇️
Pablo Arantes - @pabloarantes.bsky.social retweeted
Finally, we're releasing Chaperone, an agent framework extending upon RFD3 and many other tools for general bio-molecular design, widely used across the Baker lab and beyond!
Now available at: github.com/RosettaCommons/ch…
(more details & technical report coming soon!) 5/n
Pablo Arantes - @pabloarantes.bsky.social retweeted
Presidente Lula, vai descansar. Você é o último bastião de um sistema de democracia que ruiu.
Você transformou esse país e hoje amarga com os ressentidos e raivosos que melhoraram de vida.
O senhor não precisa mais provar nada. Já está na história.
Pablo Arantes - @pabloarantes.bsky.social retweeted
ʙɪɴᴅᴄʀᴀꜰᴛ2 is out, and we're not waiting for the paper. The full code drops today, free for academic and industry use.
We're releasing it early so you can start designing right now, and bring its full power to the current Adaptyv competition.
github.com/PacesaLab/BindCra…
Pablo Arantes - @pabloarantes.bsky.social retweeted
ColabFold 1.6.3 is out! 2.5x faster, pip-installable, ipSAE+pDockQ2 scores. Thanks Choonghwan Lee, Marielle Russo, Gyuri Kim, Martin Steinegger, Milot Mirdita
🐍 pip install colabfold[alphafold]
(1/3)
Pablo Arantes - @pabloarantes.bsky.social retweeted
🏆 Proud to share our team won an award at @databricks AI World Tour for our drug discovery pipeline! One of the first South American pharma companies building a complete drug design pipeline natively on the platform. 🚀🧬
#DAIWTSP #DataAIWorldTour
🏆 Proud to share our team won an award at @databricks AI World Tour for our drug discovery pipeline! One of the first South American pharma companies building a complete drug design pipeline natively on the platform. 🚀🧬
#DAIWTSP #DataAIWorldTour
Pablo Arantes - @pabloarantes.bsky.social retweeted
I gave a workshop on AlphaFold & related programs @ the University of Utah. Part 1 covers protein structure prediction before/after AlphaFold & deep learning neural networks. Part 2 covers the math behind the scores. Part 3 covers PyMOL & the webservers.
youtube.com/@rolanddunbrack
Pablo Arantes - @pabloarantes.bsky.social retweeted
DO YOURSELF A FAVOR: GO DOWNLOAD THIS NEW LOCAL MODEL AND KEEP IT IN STORAGE.
Even if you don't have a massive GPU setup, having offline access to an intelligent model is a crucial insurance policy.
Free API access won't necessarily last forever.
Right now, the 12B-27B range is the absolute sweet spot, and Hugging Models just highlighted a perfect candidate to download today:
→ GEMMA 4 12B CODER on @huggingface 🤗
It packs Google’s latest architecture into a GGUF format optimized for consumer hardware.
What it delivers locally:
→ Fast, private code completion without the cloud
→ Real-world debugging and reasoning capabilities
→ Smooth performance on 12GB+ VRAM or a standard CPU
Don't wait until you need it.
Grab the weights and keep them locally 👇
Gemma 4 12B Coder is here and it's a game changer for local code generation. This GGUF model packs Google's latest gemma-4 architecture into a compact 12B size, perfect for running on consumer hardware. It's optimized for reasoning and thinking, making it ideal for developers who want fast, private coding assistance without the cloud.
Pablo Arantes - @pabloarantes.bsky.social retweeted
Today we’re introducing Gemma 4 12B — our latest open model that brings advanced agentic reasoning, vision and audio directly to your laptop.
It delivers performance nearing our larger Gemma models with a much smaller total memory footprint, while being small enough to run locally with just 16GB of VRAM. It’s open and accessible for everyone to use under a permissive Apache 2.0 license.
This is all made possible by our new, unified architecture that removes separate multimodal encoders. Here’s how we did it 🧵
ALT Promotional graphic on a black background featuring the large blue text "Gemma 4 12B" above smaller white text that reads "Unified Transformer." A glowing blue ribbon containing multi-modal icons (representing images, text, and audio) flows from the left into a central point, branching out into a complex, luminous blue neural network map on the right.
🚀 ParametrizANI is now a Python package!
What started as Google Colab notebooks is now a full pip-installable library for fast, accessible dihedral parametrization of small molecules, SMILES to AMBER/GROMACS/OpenMM in one script.
🧵 [1/3]
Uses neural network potentials (TorchANI, MACE-OFF, AIMNet2, xTB) to achieve DFT-level accuracy on CPU. Supports GAFF2 & OpenFF force fields, AM1-BCC/RESP charges, and built-in validation (RMSE, MAE, R²).
🧵 [2/3]
📦 pip install coming + full docs at:
📄 Paper: pubs.acs.org/doi/abs/10.1021…
💻 GitHub: github.com/pablo-arantes/Par…
📚 Docs: parametrizani.readthedocs.io
#CompChem #MolecularDynamics #Python #OpenSource
Pablo Arantes - @pabloarantes.bsky.social retweeted
Vibe code without internet 🚀
I built a vibe coding app powered by Gemma 4, running fully on-device on Mac with MLX. Pick your model, then chat or build with it.
Watch it build the Chrome Dino game offline using Gemma 4 27b.
Open sourcing all of it below👇