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Joined December 2024
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"I am a computer program!" Embodiment is basically irrelevant for consciousness, so says @DavidDeutschOxf... and he brings the proof.
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People who cured / are curing their own cancer on X: 1/ @sytses - bone cancer, billionaire founder of Gitlab, developed 10+ personalized therapies for himself. 2/ @paul_conyngham - shrank his dog Rosie's mast cell cancer tumors after chemo and surgery weren't enough. Now backed by YC and Founders Fund 3/ @miriamgonp - stage 4 breast cancer, tumor sequenced, searching for vaccine manufacturer now 4/ @kevinace - stage 4 lung cancer, angel investor in 300+ companies, first drug stopped working after 18 months. Vaccine designed, now paying $300k out of pocket for the vaccine 5/ @masonbgrant: going founder mode on his his 32-year-old wife's rare liver cancer, sequencing her tumor with AI agents 6/ @ArunRLverma: former product leader at Atoms and Shopify, brain tumor, built a vaccine from his tumor. Now building an AI health agent startup based on what he went through We're going to make it
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Hey Claude, give me a summary of @DavidDeutschOxf's Beginning of Infinity:
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The internet is amazing
I've attempted to map everything in oncology in a public website and open source repo for all. The site is trying to get all cancers, products, technologies, bottlenecks, people, startup opportunities with 1000+ ideas for upgrading the field. If you have a loved one with cancer and you are technical or can engineer, go take a look, file improvement requests or bugs or help with the open repo and make this the best open and free info resource for individuals, researchers and educational use. This should save people time, aid AI oncology projects and generate positive action. If you are not technical just complain in this thread about broken or annoying or things you want and I'll fix them live. Some of the interesting pages: Treatments: onco.cc/drugs A gallery of the molecules being used onco.cc/molecules/ And targets: onco.cc/targets/ The technologies in oncology: onco.cc/technologies/ 1100 ideas for helping oncology: onco.cc/ideas/ Bottlenecks on oncology: onco.cc/bottlenecks/ Open questions (LETS GO RESEARCH PEOPLE) onco.cc/open-questions/ Startup requests (LETS GO STARTUP PEOPLE) onco.cc/startup-requests/ Mechanics of cancer: onco.cc/mechanics Battlefronts: onco.cc/fronts/ Isotope supply: onco.cc/isotopes Key papers: onco.cc/key-papers Pipeline funnels: onco.cc/pipeline Cancer by type: onco.cc/cancers/ Institutional rankings: onco.cc/institutions/ The startups: onco.cc/startups/ Heros and heroines : onco.cc/heroes/ Key medical people: onco.cc/people/ Here is the project roadmap: onco.cc/roadmap/ Models and data sets: onco.cc/models/ There are other views as well, take a browse. Try making a PR if you have an upgrade to this on the repo here: github.com/judegomila/OnCo If you are biologically/medically minded and something is wrong, file a bug as well or say on the thread and we will get it fixed live. If this is a useful project star the repo and help get it calibrated. I've tried to add some other languages but I cannot speak them so tell me if that doesnt work well. I believe we will crack oncology and having total information dominance is key to the problem. Let the feedback flow!
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I was there:
Can LLMs reach AGI—and genuine explanatory creativity? A discussion at Oxford Physics with David Deutsch, Adam Brown, Nick Bostrom, Vedika Khemani, Roger Myerson, Rahul Nandkishore, Toby Ord, Martin Rees, Anders Sandberg, Umesh Vazirani & K. VijayRaghavan drive.google.com/file/d/1kxv…
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Here is the quick version: Out of college I was a Mortgage Loan Officer for ~2.5 years. Real boiler room style bank - cold calling off of call sheets etc… In 2016 I decided I was miserable enough to make a real change and went to General Assembly Coding Bootcamp 1/1/2017 I started my first job in tech at a small AdTech startup. 10 people in a room at a wework I spent the next ~8 years bouncing around different Technical Account Manager & Sales Engineering jobs until I landed at (what I thought) was the pinnacle - my last job I held making about the number I mentioned in the quoted tweet Fast forward to 2023 and to no surprise… I was still miserable The problem: I had a wife, kid on the way, mortgage, 2 cars, a dog, and a white picket fence I started The Outgoing Co (Ramp Health then) at the beginning of 2023 Shipped out first orders by July 2023 By November 2024 we were doing ~$50k/mo and I decided to grab my nuts and quit Liquidated investments & 401k, opened an “oh shit” line of credit, and took on an investment partner That was almost 2 years ago and here we are 🫡
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I just fixed my dishwasher with the help of ChatGPT. A trivial task. I had been about to order a new one. So this software has increased the country's real wealth yet decreased the measured GDP. The main economic indicator is structurally incapable of registering the thing that actually makes people better off, namely the growth of knowledge
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Best way to “rehab” the shoulder (aka how to use it correctly) is to get the big arch out of the low back This is forcing the scaps to adduct (squeeze together) and rotate down when they need to do the opposite. This just feeds the problem you probably already have.
This is incredible
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uatx.substack.com/p/forget-y… Hmm. I'd say the Enlightenment version of individualism is the historically unique idea that individuals exist not for the sake of their ruler, their class, their ancestors, their gods, or any other such superstition, but for their own sake. Meaning does not require subordination to something "greater than oneself". It is created by the idea that progress is possible and desirable – not by a leap to utopia, but endlessly into the future by undirected problem-solving, carried forward voluntarily by individuals for their own reasons.
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More than can go into one tweet! I’d start by doing one of the following (or both, frankly). Full disclosure: I’m the creator of Option A. Option A: 1. Install Tailscale on your computer and phone to create a secure device-to-device connection tbat works over cellular and wi-fi, and log in on both. Takes 2-3 minutes. tailscale.com/download 2. Install VoiceClaw Realtime on your iPhone and install the Voiceclaw Realtime computer Companion app on your computer. Takes 2 minutes. voiceclawrealtime.com 2. In VoiceClaw Realtime on your phone, tap sign in with ChatGPT using the in-app button. This lets you use OpenAI models, including its Realtime/Live two-way voice models. 3. In VoiceClaw Realtime on your phone, press the QR button and scan the QR code from the VoiceClaw Realtime desktop companion app to securely pair it to your phone. (Note: the data is not transmitted to a third party; the QR pairing is just a convenient way to send VoiceClaw Realtime’s desktop settings to the iOS app, instead of manually typing in the settings yourself.) Now you can live voice chat continuously with natural voice to operate OpenClaw, have it do real computer work (anything you can think of), and send/receive files, right in the app. (To have it do computer work even more effectively, install the ChatGPT app on the computer as well, sign into it with your ChatGPT account, tell OpenClaw “please set up the OpenClaw ChatGPT/Codex Computer Use feature/plugin and restart the OpenClaw gateway,” wait five minutes, restart the VoiceClaw Companion desktop app and re-scan the QR code.) That’s Option A. (Note: with VoiceClaw Realtime, you can live voice chat without using computer-side agents if you skip the desktop Companion / QR code computer-pairing step, and can still upload files/images for analysis while voice chatting with GPT Realtime / Live. ————- Option B 1. Install Tailscale on your computer and phone to create a secure device-to-device connection tbat works over cellular and wi-fi, and log in on both. Takes 2-3 minutes. tailscale.com/download. When it’s set up, go to settings and note your private Tailscale “tailnet” URL (it ends in “ts.net”). 2. Install Matrix (a free self-hosted chat server that runs on your computer) and set its “homeserver URL” to be that computer’s tailscale URL (like bobscomputer.yourfreetailsca…) or to be a new Tailscale subdomain (like matrix.yourfreetailscaleurl.…). You can ask OpenClaw (or OpenAI’s Codex, within the ChatGPT desktop app) to do this for you, end-to-end. It will take 15 minutes or so. If you don’t have auto-approve settings on, stay by your computer so you can click “Approve” a bunch of times. 3. Create a Matrix user account for yourself and one for your OpenClaw agent (or more accounts for multiple OpenClaw agents, if you have multiple OpenClaw agents). OpenClaw or Codex can do this for you, too. 4. Add the OpenClaw Matrix messaging plugin to your OpenClaw installation and configuring each OpenClaw agent to a Matrix user account (like “AgentA” in OpenClaw is “AgentA” in Matrix). OpenClaw or Codex can do this for you, too. 5. Download the free Element chat apps on your phones, tablets, and/or other computers and log in using the homeserver URL you created and the Matrix username you created for yourself. Create a room, give it a name, and invite your OpenClaw agent by typing their name in the “invite user” screen. Now you can chat with and send/receive files from your OpenClaw agent(s) in a convenient secure chat app, and create new chat rooms that you can label however you like (for projects, clients, different areas of your life, etc.). Or, just use one Matrix chat room for everything. That’s option B. —— I say do both Option A and Option B: Option A for live, real-time, continuous, two-way natural language voice operation; you just talk, and if you want OpenClaw (or Codex / Hermes) to do computer work, just say so. Option B for the traditional chat-app approach.
Replying to @BenjaminBadejo
You have any recommendations on how to best set up Openclaw and run it? I have it installed and set up currently.
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My life is a near constant state of mild annoyance, discomfort, foiled expectations, and boredom, and yet I’ve never been happier. I’ve transitioned to stay-at-home dad to five kids aged 2-8 and, on a moment to moment basis, it’s rarely fun. It’s almost never the case that all five are in a good mood, that nobody is asking me for something, nobody is disappointed or outright upset. The plans I make for the day rarely work out, and almost never work out for everyone. I make blatant mistakes all the time - I forgot the diapers, I left the crocs somewhere, the kids were too hungry and started fighting at the science museum, the water was too cold, etc etc. And I rarely get a chance to have an extended conversation with an adult, to read/listen to a good book, or to write out my thoughts on X (posting has fallen off dramatically this summer.) But, I’ve never been “happier.” This is easily the greatest period of my life, and I’m not sugarcoating it just to pretend that I’m a devoted husband/father. I also reject the “no pain, no gain” ethos that says that hard things are inherently satisfying, or that satisfaction can only come from struggle. (I absolutely cannot stand the common practice of rationalizing an unpleasant existence instead of improving it.) How can this be, that I’m both happy and unhappy at the same time? It’s because the word happy has several uses, and this has caused a lot of confusion. A simple clarifying distinction is between happiness as feeling good, and happiness as satisfaction. Writing this strikes me as so obvious that I’m tempted not to post it, but the confusion runs quite deep. I started following the happiness research in 2006 when I read Jonathan Haidt’s Happiness Hypothesis and then Daniel Gilbert’s Stumbling on Happiness and Csikszentmihalyi’s Flow and Barry Schwartz’s The Paradox of Choice, and their arguments were based on these experiments where they’d measure happiness with surveys, with asking people how happy they were in various circumstances. They called this science because they did all this scientific stuff around these surveys and published it as the psychology of positive emotions, of happiness. I lapped it up because it made so much sense. Before these guys, psychologists only studied pathology, depression, insanity, addiction, stuff like that. What about happiness? These guys did acknowledge, almost in passing, that what someone says about their state of mind (a survey response) is not actually their state of mind, but they said that if they simply collect enough responses and average them together, then the result would actually reflect their state, at least to some statistical probability. And after all, is there a better way to get at someone’s state of mind other than just asking them? I remember sitting on the floor and watching them sweep this ugly little fact under the rug and calling it good myself. Heck, this stuff was published psychology, and to my 2006 self, that was good enough for me, especially when the stuff they wrote in their books and said in their TESTalks made so much damned sense. But I never forgot that rug sweeping definitely happened. Fast forward to 2018 and it all crashed down with a paragraph in my favorite book, The Beginning of Infinity. Throughout the book, @DavidDeutschOxf is at pains (quite happily, I bet) to make the case that we don’t understand stuff that we can’t explain, and if we can’t explain it, then we can't make meaningful predictions. We certainly can make predictions, they're just not meaningful. Take astrologers, they make lots of predictions, but since astrology lacks an explanation of HOW star positions affect human affairs, astrology can only succeed by getting its patrons to ignore this lack of understanding, usually by misdirecting their attention on mumbo jumbo like mystical vagaries and credulous testimonials. In other words, charlatans use various methods to sweep their lack of an explanation under the rug, and science (and knowledge creation in general) is about pulling things OUT from under the rug! (Deutsch references conjuring tricks multiple times throughout the book.) In Chp 12 A Physicist’s History of Bad Philosophy he addresses happiness research head on. He notes that we don’t have an explanatory theory of what happiness is, so, like astrology, predictions about happiness are bullshit. Instead, happiness research is full of supposedly happy behaviors, like checking boxes on surveys that say “I am happy." But we don't have an explanatory connection between those checkmarks, those behaviors, and the actual state of someone's mind, just like astrologers don't have an explanatory connection between the location of stars and their patron's romantic prospects. Deutsch notes that, not only do we have no way of measuring happiness (measuring happiness without understanding it is like measuring temperature without a theory of thermodynamics), we know that "some people believe that behaving in 'happy' ways is a remedy for unhappiness, so, for those people, such behaviors might be a proxy for unhappiness." I never heard the happiness researchers account for that inconvenient little tidbit. The point I've been driving at so far is that we shouldn't put much stock in conventional ideas about happiness, including that it's a goal we should even strive for, because we don't understand it. What is the alternative? I think the alternative is rearranging the order. Instead of seeking the feeling or state of being, we should seek something meaningful, "satisfying," important, and let the feeling state derive from that. As @Supreme_Owl_FTW says, we need to avoid putting the cart (feeling) before the horse (meaning). For a longer treatment on this, I enjoyed Raymond Angelo Belliotti's Happiness is Overrated. In it he points out what I am currently experiencing, having a good life raising five kids with a loving wife even though my day-to-day is rarely happy. (It has its moments, don't get me wrong, but they are... infrequent.) Wrapping up with some basic points: I think it's a bad idea to constantly assess how we're feeling. I think it's a bad idea to ignore feeling bad. Feeling bad is always a signal that something can be improved. Problems are solvable. Also a bad idea to ignore feeling good, feeling good is great and amplifying the causes of good feels is great, all things considered of course. All things considered means amplifying feeling good (and alleviating feeling bad) often comes at a cost, and the costs may not be worth it. Ignoring the costs of optimizing how you feel is a good way to feel bad. Often I don't have the energy to solve a problem and I just endure it. It's easier to endure discomfort when I'm not pressuring myself to optimize my life. I often reevaluate my overall goals, how things are going with the kids, how they are doing/growing, how me and my wife are doing etc. This helps to avoid complacency and bullshitting myself, such as telling myself that, since I'm doing something wholesome like taking care of the kids, everything is fine. What is meaningful and important is very, very specific to each person. Beware off-the-shelf sources of meaning as they are almost always too blunt to fit one's specific life. And worse, they are loaded with social approval and other anti-rational reasons to adopt them. Finding meaning requires constructing meaning. Something that matters to you has to be deeply understood by you. It has to be deeply interesting. And the way to arrive there very likely involved allowing your creativity to engage with it at some length and with few restrictions.
Happiness is not the point, happiness is downstream of solving interesting problems. Progress expands the scope of available interesting problems.
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I found a lot of value in thinking this through and writing it down
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True invention is indeed unpredictable, not an efficient, undistracted straight line. Wandering invention is efficient in a different way, though. It is guided by problems, by intuitions and interestingness and taste, all of which can be highly sophisticated and selective.
Jeff Bezos explains the Wandering Rule behind real invention: "When I sit down to work on a problem, I know I don't know where I'm going." "To go in a straight line, to be efficient, efficiency and invention are sort of at odds." "Real invention, not incremental improvement... real lateral thinking... requires wandering." "You have to give yourself permission to wander." "A lot of people feel like wandering is inefficient." "I don't know how long the meeting is going to take if we're trying to solve a problem." The useful distinction: Use efficiency when the path is known. Use wandering when the problem is still being discovered. Most teams kill invention by demanding a straight line too early.
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1 Human progress (knowledge/problem solving) is amazing 2 Evolution is amazing I'm currently reading 'The Fabric of Reality' (again) by @DavidDeutschOxf - human knowledge is a fundamental force of Nature, it shapes the environment we live in.
Got an MRI of my heart yesterday. How is this thing the result of blind evolution?
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Transhumanism and Escaping Evolution As we create new knowledge, the proportion of genetic knowledge we depend on goes to zero. We keep making new stuff, while our genomes stay the same. ~Conjecture Institute Fellow @dela3499 w/ Ambassador @ToKTeacher
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.@DavidDeutschOxf on probability: "There is no such thing as probability at a fundamental level. The world is deterministic. We only need probability to make decisions." Determinism all the way down.
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One of the most profound insights from our chat with @DavidDeutschOxf. We cannot define creativity, knowledge or explanation. No “formal system” - no regular algorithm as we understand it - can bound them. Now why? Listen below. Featuring @naval getairchat.com/bretthall/the…
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