Pranav Lalgudi (@plalgudi11) profile picture

PhD student at @Stanford Genetics @mfgrp, previously @MIT Biology '21

Joined December 2020
A special shoutout here to @plalgudi11, seen here helping to spot *the grids* almost four years ago to the day at MIT!
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Today in @Nature we report a systematic strategy to activate & identify gene sets in plants. We identify 8 new genes from the yew tree's Taxol biosynthetic pathway, enabling us to engineer tobacco with 17- & 20-gene pathways to Taxol precursors baccatin III and dBz-deoxy-Taxol. a thread 1/x.. nature.com/articles/s41586-0… With amazing coauthors @Sattely_lab @ctliu629 @fordycelab @Stanford_ChEMH @StanfordEng
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In this week’s @Nature, we report that nutrients do not activate mTORC1 through degradation of GATOR1 component DEPDC5. Other molecular events signal the presence of amino acids to this essential growth pathway! nature.com/articles/s41586-0…
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Pranav Lalgudi retweeted
Today we report that an engineered skin bacterium, swabbed gently on the head of a mouse, can unleash a potent antibody response against a pathogen. Could lead to topical vaccines that are applied in a cream. @DjenetBousbaine led the charge... @Nature 1/55
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Out in @PNASNews now, we find that the Rag-Ragulator heptamer anchors the GATOR supercomplex to the lysosome. Our results highlight the complex role the Rags play in regulating mTORC1 activation and lysosomal homeostasis (1/2)
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Pranav Lalgudi retweeted
Super excited to share this collaborative work @Nature that focuses on the roles of Sestrin-mTORC1 in organismal dietary leucine response. So much fun working with @PJouandin from @PerrimonLab. Thank all co-authors for their very valuable contributions.nature.com/articles/s41586-0…
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Excited and grateful to share this with the world! Our structure of the mysterious GATOR2 complex sheds light on the ways that mTORC1 receives and integrates nutrient signals. Thank you to everyone who contributed to this work! 🐊🐊
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🤯 KLAY THOMPSON 💪 #KlayThompson || #NBAAllStar
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Pranav Lalgudi retweeted
Welcome 𝗵𝗼𝗺𝗲, @Cristiano 🔴 #MUFC | #Ronaldo

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