Prevention of respiratory insuffiency after surgical management (PRISM) trial: an international multi-centre RCT of CPAP after major abdominal surgery.
Europe
Joined January 2015
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PRISM Trial retweeted
8/ A big thank you to our international teams of investigators across Europe & South Africa and to our funders @NIHRresearch @Barts_Charity @Assoc_Anaes @intersurgical & @unirome1 Thank you! @IbJammer @BruceBiccard @caldecoaal @iamyourgasman @prismtrial @CCPMG_TEAM
PRISM Trial retweeted
7/ The results of @prismtrial do not support the routine use of postoperative CPAP to prevent pneumonia, re-intubation or death after major abdominal surgery. sciencedirect.com/science/ar… @rupert_pearse @CCPMG_TEAM @QMULWHRI @QMULBartsTheLon
PRISM Trial retweeted
6/ We found no differences between CPAP and standard postoperative care for any of our pre-specified secondary outcomes. sciencedirect.com/science/ar… @prismtrial
PRISM Trial retweeted
5/ 8.1% of patients in the CPAP group met the primary outcome of pneumonia, re-intubation or death within 30 days after randomisation compared to 8.2% of patients in the usual care group (odds ratio 1.01, p=0.95). sciencedirect.com/science/ar… @prismtrial
PRISM Trial retweeted
4/ The primary outcome was a composite of pneumonia, endotracheal re-intubation or death within 30 days after randomisation. We undertook an intention to treat analysis according to published protocol minervamedica.it/en/journals… @prismtrial
PRISM Trial retweeted
3/ Patients were randomly assigned to receive either Continuous Positive Airway Pressure (CPAP) within 4hr after the end of surgery or usual postoperative care. @prismtrial sciencedirect.com/science/ar…
PRISM Trial retweeted
2/ We included 4793 patients aged over 50 years undergoing major open abdominal surgery from 70 hospitals across Italy, Spain, Norway, Sweden, South Africa & the UK between Feb 2016 & Nov 2019. @prismtrial @BruceBiccard @IbJammer @caldecoaal @CCPMG_TEAM sciencedirect.com/science/ar…
PRISM Trial retweeted
Published today in @LancetRespirMed is the final report of @prismtrial, an international multi-centre phase-3 randomised trial of routine postoperative CPAP to prevent pneumonia, re-intubation & death after major abdominal surgery sciencedirect.com/science/ar… @rupert_pearse @QMULWHRI
The final report of PRISM trial has been published by @LancetRespirMed Here, @rupert_pearse gives a video summary youtu.be/kYSHWmluwPc Thread below: @_tomabbott gives a summary of the key results.
Link to download paper: sciencedirect.com/science/ar…
Published today in @LancetRespirMed is the final report of @prismtrial, an international multi-centre phase-3 randomised trial of routine postoperative CPAP to prevent pneumonia, re-intubation & death after major abdominal surgery sciencedirect.com/science/ar… @rupert_pearse @QMULWHRI
PRISM Trial retweeted
Interesting trial of CPAP vs usual care post-op for major surgery by @rupert_pearse’s team. No difference between the groups though.
Important trial, especially as we might assume treatments like this work, they certainly make our numbers better. #Anaesthesia2021
For those that missed the talk at #Anaesthesia2021 you can see a pre-recorded video of @rupert_pearse presenting the results of @prismtrial here: youtu.be/kYSHWmluwPc
Or visit our website: prismtrial.org doi.org/10.1016/S2213-2600(2…
@prismtrial found no difference in the incidence of pneumonia, re-intubation or death within 30 days of surgery between patients randomised to CPAP or usual postoperative care. #Anaesthesia2021
PRISM Trial retweeted
.@rupert_pearse explains in the prelude to @prismtrial - there *may* be a @CochraneUK signal towards the use of CPAP in abdominal surgery
#Anaesthesia2021
We are excited that @rupert_pearse will be presenting the results of @prismtrial at #Anaesthesia2021 at 12.10 today. Find out about routine postoperative CPAP here. @CCPMG_TEAM @RCoANews
PRISM Trial retweeted
1/ Increasing numbers of patients aged 75 or older are undergoing surgery, but it is unclear whether these treatments are needed or whether they improve quality of life. academic.oup.com/bjs/article… @_alexfowler @rupert_pearse @BJSurgery
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PRISM Trial retweeted
Patients with covid at ‘very high risk of death’ after surgery | Evening Standard Research from @_tomabbott @_alexfowler @rupert_pearse @CCPMG_TEAM @QMUL @standardnews standard.co.uk/news/health/p…
PRISM Trial retweeted
We estimate that the financial cost of clearing the current backlog of postponed operations in @NHSEngland is ~£1.3bn. This could increase to over ~£5bn by March 2021 as the reintroduction of elective surgery will be gradual. medrxiv.org/content/10.1101/… (Pre-print. Not peer-reviewed)
Our modelling analysis suggests that ~750,000 operations may have already been postponed in @NHSEngland due to COVID-19, which could increase to ~2.2 million by March 2021 as elective surgery is gradually reintroduced medrxiv.org/cgi/content/shor… (Pre-print. Not yet peer-reviewed).
PRISM Trial retweeted
Our modelling analysis suggests that ~750,000 operations may have already been postponed in @NHSEngland due to COVID-19, which could increase to ~2.2 million by March 2021 as elective surgery is gradually reintroduced medrxiv.org/cgi/content/shor… (Pre-print. Not yet peer-reviewed).
Last weekend our @BJSurgery article on elective surgery cancellations due to COVID-19 was covered last weekend by the Sunday Express and Daily Mail
Key message- health systems including UK's NHS should urgently plan how to tackle the surgery backlog
🔗bjssjournals.onlinelibrary.w…
We're still celebrating the end of recruitment! Massive thank you to the fantastic recovery team at @RoyalLondonHosp ... we couldn't have done it without you! (And yes, that is more cake) @peri_team @rupert_pearse @MariaFer_RLH @ResearchTim @SurgeryRlh @PabloRubioRogla @awleitch
