JRF @stjohnscam & @DeptofPhysics//Light rules!//Alumnus @PhotonFactoryNZ//Loves history, horror, & pays no heed to science discipline boundaries 🇳🇿🇲🇾
Cambridge, UK
Joined February 2019
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Rakesh Arul retweeted
An extraordinary @Nature paper has just landed from the lab of @Sergiu_P_Pasca at @Stanford - led by Konstantin Kaganovsky. They have found a way to create "xenocortical mice" which have ~92% of their cortex occupied by a cortical organoid derived from human stem cells. This human-derived cortical graft integrates deeply with the host nervous system, supporting organised neural activity and behaviour.
This study is a milestone in synthetic biology and chimera research. It has the potential to generate multiple medical breakthroughs by providing an enhanced biological model of human brain tissue that allows behavioural as well as neural and genetic assays.
The Stanford team have been exceptionally thorough and proactive in addressing ethical concerns that comes from this frontier work. But their pioneering work nonetheless raises many open questions: are the xenocortical mice conscious? Do they have any human-like properties of consciousness or cognition?
@NitaFarahany and I will be addressing some of these questions in a forthcoming commentary - where we'll also offer an ethically-informed roadmap to guide this important research as it progresses. In this context, "pacing the frontier" really does make sense 😉
Read the Stanford @nature paper here, and buckle up. It's wild. nature.com/articles/s41586-0…
Rakesh Arul retweeted
Our group discovered that reasoning models produce fractals when asked to solve hard problems. We can use nonlinear dynamics to probe the thinking processes of recurrent depth models on Sudoku, mathematics, and even ARC-AGI (1/N)
arxiv.org/abs/2609.04963
Rakesh Arul retweeted
There were so many hilarious submissions (over 100!!) so I unfortunately can't highlight them all, but there are some that literally made me LOL
Rakesh Arul retweeted
hello there the jacobian conjecture is false thanx to my close friend akhil for asking about it and my other close friend fable for working during the world cup final
((1+xy)^3 z + y^2 (1+xy) (4+3xy), y + 3 x (1+xy)^2 z + 3 x y^2 (4+3xy), 2 x - 3 x^2 y - x^3 z): \C^3\to \C^3, has jacobian determinant -2, and sends (0, 0, -1/4), (1, -3/2, 13/2), and (-1, 3/2, 13/2) to (-1/4, 0, 0)
Rakesh Arul retweeted
Cavendish researchers have found a new way to make forbidden molecular triplet states shine. This could lead to brighter OLED materials, better imaging technologies, and future quantum sensing 👉️buff.ly/IbDB3N7
@HuangtianzhiZ @quantizedfella @zhongzheng_yu @stjohnscam
ALT Image description: Triplet states glowing on anthracene molecules attached to lanthanide nanocrystals in solution Image credit: Rakesh Arul, Huangtianzhi Zhu, Google Gemini, Powerpoint
Rakesh Arul retweeted
An excellent and thoroughly enjoyable retreat with the Rao Group in Fethiye, Türkiye. Thanks to Akshay and colleagues for the fun memories!
@NidhishSagar @quantizedfella @zhongzheng_yu @yunzhoudeng @Bofeng_Xue @HuangtianzhiZ @EbinZebu @harv_mac @kueyoung_k
Rakesh Arul retweeted
A tour de force single molecule review @ScienceMagazine
"the ongoing convergence of two foundational technologies in modern biology: sequencing and single-molecule biophysics......we are now poised to interrogate complex biological phenomena with previously
unattainable depth and precision."
science.org/doi/10.1126/scie…
Rakesh Arul retweeted
Nature research paper: Triplets electrically turn on insulating lanthanide-doped nanoparticles
go.nature.com/47O6qeO
Rakesh Arul retweeted
Cavendish researchers have developed a new technique using 'molecular antennas' to power nanoparticles that couldn't be electrically powered before🔋
This opens up exciting opportunities to use these excellent light emitters in everyday technology.
🔗buff.ly/GM1IBun
ALT Artist’s illustration of a lanthanide-doped nanoparticle: a black spider with its back glowing red, on a web which parts glow blue.
Rakesh Arul retweeted
Can a pinch of salt lead to better medical tests, cleaner energy, and smarter sensors?
Researchers have shown that a layer of chloride ions, like those in table salt, can fundamentally alter the behaviour of gold nanoparticles.
🧂 buff.ly/47wn7as
ALT Small floating balls coated in gold.
Rakesh Arul retweeted
Why fundamental research is fundamental to progress, seeding major breakthroughs
Editorial @Nature this week
And 7 basic science discoveries that changed the world
nature.com/articles/d41586-0…
nature.com/articles/d41586-0…
Rakesh Arul retweeted
Looking for an enthusiastic PhD student to come to Oxford next year to design and synthesise cool luminescent organics. Please share 🙂 @OxfordChemistry @ERC_Research
jobs.ac.uk/job/DOY750/dphil-…
Rakesh Arul retweeted
✨ Cavendish researchers have found a way to tune tiny clusters of metal nanoparticles to interact with light in surprising ways.
The findings could improve non-invasive sensing technologies for #healthcare and environmental monitoring.
Read the article: buff.ly/XFMKjCH
ALT Graphical representation of small molecule sensing using a mid-infrared metamaterial made of gold nanoparticles
Rakesh Arul retweeted
In 1974, the mathematician Douglas Hofstadter used a graphing calculator to find a fractal pattern in how electrons behave. His adviser dismissed it as numerology. The fractal, called the Hofstadter butterfly, is now known to be a real-life phenomenon. quantamagazine.org/ten-marti…
Rakesh Arul retweeted
The creative process in science has its thinking tools, which we all learn eventually. Here are the 12 articles that Martin and I wrote about them, including "It takes two to think" and "A hypothesis is a liability". night-science.org/home/learn… @nightsciencepod @MartinJLercher
Rakesh Arul retweeted
Next in our Cavendish research theme series: #NanoPhotonics
The science and application of light—at the tiniest scales imaginable.
At the Cavendish, researchers are exploring how to confine light to structures over 100 times smaller than its wavelength. 🔗buff.ly/OJTmGlo
Rakesh Arul retweeted
👉We just posted the final program for the 2025 Gordon Conference on Plasmonically Powered Processes: Transforming Elementary Plasmonic Excitations into Functional Devices. grc.org/plasmonically-powere…
🙏Proud to be Chair of this edition! ☀️We’ve got an amazing lineup of speakers!😍
Rakesh Arul retweeted
Huge update to our preprint today on the superhuman performance of reasoning models in medical diagnosis!
TL;DR – they don't just surpass humans in meaningful benchmarks, but in actual medical care from unstructured clinical data:
A 🧵⬇️:
teapawt.net/AdamRodmanMD/status/18…
Preprint out today that tests o1-preview's medical reasoning experiments against a baseline of 100s of clinicians.
In this case the title says it all:
Superhuman performance of a large language model on the reasoning tasks of a physician
Link: arxiv.org/abs/2412.10849
A 🧵⬇️
Rakesh Arul retweeted
🔥Super excited to share our latest work out now in @ScienceMagazine science.org/doi/10.1126/scie…
This paper describes the discovery of "glycosyrin" a small molecule produced by the bacterial pathogen P. syringae to manipulate glycobiology inside host plants during infection.🧵1/20
