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maybe fasting while doing combo therapies was more helpful than i realized open.substack.com/pub/danilo…
Rohan retweeted
Dr. Tim Henrich presented new findings surrounding long term persistence of SARS-CoV-2 proteins & RNA in Long COVID gut tissue at PolyBio’s recent Spring symposium. “We actually see [gut viral persistence] in both areas, the epithelium—which turns over every several days to week—to the lamina propria where you have long-lived myeloid immune cells… suggesting there may even be replication in some individuals,” said Henrich.
Using a highly sensitive method of detecting viral RNA, “around 20-25% of the time, we see detection… all the way up until 3-4 years after initial infection” in Long COVID patients.
Rohan retweeted
People who tested positive for #COVID have a higher risk of being diagnosed with other infections in the following months. This has been shown for years and hundreds of publications in the topic. Covid has an impact on the immune system we still don't fully understand.
Why Covid could be to blame for the rise in deadly meningitis, according to scientists - and the early symptoms of the disease that patients must act on trib.al/XW4xOX8
Again and again we see viruses linked to dementia and neurodegenerative disorders. This new study (n>160,000) showed high dose flu vaccines reduces Alzheimer's dementia.
We've seen the Shingles vaccine is linked with reduced risk of Alzheimer's and dementias in 4 large natural experiments.
Today, the potential of high-dose flu vaccines vs standard dose for the same in a large retrospective age 65+ cohort [N>160,000). More pronounced in women (like Shingles vaccine)
neurology.org/doi/pdf/10.121…
What about dementia, specifically? We may need to wait for researchers with access to large epidemiological datasets to find out.
If anyone is working with large datasets that might be relevant here, please reach out to @longcovidlabs - we'd love to help support this research.
Rohan retweeted
Lots of clinical trials for Long COVID coming out. Here's a quick guide on how to assess it.
A study is getting quite a bit of coverage, suggesting that the antidepressant fluvaxamine is effective for Long COVID. We'll use it as an example.
acpjournals.org/doi/10.7326/…
One of those "hand-washing reduces infections" paradigm shifts - the role of viruses in accelerating aging is still not fully acknowledged.
I predict COVID-19 will, unfortunately, be a prime catalyst for this.
Fascinating. May explain the micro-dosing GLP-1 protocols for Long COVID - we know there is significant dysautonomia and vagus nerve dysfunction.
Ozempic and GLP-1 cause weight loss via the vagus nerve. In people whose vagus nerve was surgically cut (below the diaphragm, not in the neck), GLP-1 did not reduce food intake or accelerate metabolism. These drugs work through the vagus, in ways we still do not fully understand.
ALT https://pmc.ncbi.nlm.nih.gov/articles/PMC8714868/
Rohan retweeted
National Taiwan University researchers analyzed data from over 97 million individuals and found that COVID-19 is linked to a 49% higher risk of developing autoimmune diseases.
The risk rose after severe infection but dropped by 44% in vaccinated people.
link.springer.com/article/10…
Rohan retweeted
A new RECOVER study of 6.4M health records shows Long COVID risk has not decreased from 2020–2024. Incidence stayed stable across variants, reinforcing Long COVID as an ongoing public health priority.
Read the study: doi.org/10.1093/cid/ciaf046
ALT New Study: Long COVID Risk Has Not Decreased Over Time Image of a virus (Arrow pointing right) Small Citation
3 years after antivirals and monoclonal antibodies cured my long COVID symptoms. Science can feel painfully slow. But hats off to the scientists, doctors and companies pushing the rock up the hill.
We need a global Moonshot for Long COVID, now.
New cases series: @Invivyd's Pemgarda (Pemivibart) monoclonal antibodies shown to reduce PEM in three heterogenous Long COVID cases
Is this the first evidence published in a scientific journal of COVID-specific mAbs treating PEM in Long COVID?
Rohan retweeted
Urine tells the story of #LongCOVID:
➡️ New study identifies a molecular fingerprint for #LongCOVID (PASC) — using just a urine test.
➡️ Researchers found 195 urinary peptides that can accurately distinguish Long COVID patients from healthy and ME/CFS controls (AUC > 0.95). 1/
Long COVID is now the most common childhood disease in the U.S. -- so predictable, and so sad.
PBS: What do you want people who haven’t been affected by LC to know about this community?
@meighanstone: Americans may feel like the pandemic is over.. but even in just last few months we saw the announcement that #LongCovid is now the most common childhood illness in the US
It’s a slow-moving spiral: first their health, then their grades, then their future. Those for whom Covid looms very present are feeling forgotten, subject to pervasive skepticism and a kind of cultural fatigue when it comes to their illness.
🔗 rollingstone.com/culture/cul…
