Our science approaches treating pain in a new way that is targeted and highly selective, resulting in non-addictive solutions to address the opioid epidemic.
Tucson, AZ
Joined August 2017
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Regulonix Holding, Inc retweeted
Here is the PubMed link to the paper:
Druggability of CRMP2 for neurodegenerative diseases pubmed.ncbi.nlm.nih.gov/3269…
New @KhannaLabUA manuscript, in press @ACSChemNeurosci - with @AubinMoutal @a_chfdvlle @mpatek_ @LisaBoinon Perez-Miller - reviews discovery, functions, & current putative pre-clinical/clinical therapeutics targeting CRMP2, a protein linked to the pathomechanisms of many diseases
ALT Finding 'druggable' pockets on CRMP2 sets the stage for optimization of current pre-clinical and clinical compounds (e.g. Edonerpic maleate, lanthionine ketimine ester, Naringenin, Lacosamide) as well as for de novo drug discovery targeting this multifunctional protein.
Regulonix Holding, Inc retweeted
Very excited to share this preprint implicating the SARS-CoV-2 Spike protein in analgesia, now out in @biorxiv_neursci. First, so incredibly proud of the entire @KhannaLabUA and @AubinMoutal team @LisaBoinon @DrSong13 @Kimgmz6 @HJStratton13 and Laurent Martin and others for this – at Catalina Foothills, AZ
Regulonix Holding, Inc retweeted
In this review in Neurobiology of Pain we describe a new target in #pain - the large amino acid transporter LAT1 (aka Slc7a5).
What is it & what does it do, you ask?
1. It’s an essential amino acid transporter.
2. LAT1 is expressed in the dorsal root ganglia and spinal cord – at Catalina Foothills, AZ
Regulonix Holding, Inc retweeted
A new paper from @KhannaLabUA with @AubinMoutal @UAZMedTucson @UAZBIO5 in Molecular Brain rdcu.be/b47Xj
1. we show immunohistochemical analysis of CRMP2 expression & phosphorylation in sciatic nerve, skin, DRG & spinal cord from rats with a spared nerve injury.
Regulonix Holding, Inc retweeted
Regulonix: A Scientific Quest youtu.be/vTEwX3U9GUA via @YouTube
Watch the compelling story behind the unique mechanism of selectively regulating the trafficking and surface concentration of #sodiumchannel Nav1.7 - @regulonix @KhannaLabUA #opioidcrisis #ionchannels
Regulonix Holding, Inc retweeted
Congrats to the new cohort!
We are kicking off our S20 AEP off with a (virtual) bang!
The five teams of #entrepreneurs that make up our newest AEP cohort are sharing their intro pitches about the innovative ways they seek to solve the biggest problems of our time.
#FORGEAhead
Regulonix Holding, Inc retweeted
Fresh from the Khanna lab @KhannaLabUA - a new T-type #calcium #ionchannels blocker with large spectrum analgesic properties #chronicpain. Very nice work! Congrats to the team! pdfs.journals.lww.com/pain/9…
Regulonix Holding, Inc retweeted
Preparing for the video abstract for our CRM2-SUMO null mouse and sex-specific regulation of NaV1.7 paper accepted in @PAINthejournal and selected as an for Editor’s choice article ... stay tuned!
Brevet délivré au Canada! INHIBITEURS DE LA SUMOYLATION DE CRMP2 ET UTILISATIONS ASSOCIEES
Patent granted in Canada! CRMP2 SUMOYLATION INHIBITORS AND USES THEREOF
Regulonix Holding, Inc retweeted
Way to go @KhannaLabUA!
I would like to congratulate the four @uarizona researchers who were named as senior members of the National Academy of Inventors. Here's to creating a better, healthier world #wildcatexcellence bddy.me/39JQ1Xp
Regulonix Holding, Inc retweeted
I would like to congratulate the four @uarizona researchers who were named as senior members of the National Academy of Inventors. Here's to creating a better, healthier world #wildcatexcellence bddy.me/39JQ1Xp
Regulonix Holding, Inc retweeted
Kalirin-7, a guanine-
nucleotide-exchange factor (GEF) for Rho GTPases- a new player in persistent nociceptive signaling? Another cool story from Rohini Kuner’s lab @UniHeidelberg
qxmd.com/r/25865668
Regulonix Holding, Inc retweeted
@KhannaLabUA first virtual lab meeting. Good to see everyone healthy and in good spirits.
Regulonix Holding, Inc retweeted
See also a related paper published by @UTDPainLab and Greg Dussor et al.:
Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex‐dependent onlinelibrary.wiley.com/doi/…
A UArizona Health Sciences research team led by Dr. Frank Porreca points to prolactin, a neurohormone related to lactation, as the underlying reason women experience more #pain than men, and even more so when taking #opioids. More: bit.ly/3cPLtBu
Regulonix Holding, Inc retweeted
See a synopsis of the @FASEBorg The Ion Channel Regulation Conference: Molecules to Disease held July 7-12, 2019 | Lisbon, Portugal Co-chaired by Henry Colecraft @Columbia and @KhannaLabUA -
Ion channel regulation: Molecules to disease faseb.onlinelibrary.wiley.co…
Fantastic recognition @KhannaLabUA -- congratulations! Thank you @UAZBIO5 #Spotlight focused on relieving #chronicpain
Researcher Spotlight: Dr. Rajesh Khanna is a @UAZMedTuscon professor & recent @AcadofInventors inductee. Dr. Khanna co-founded & is the chief scientific officer of @regulonix, where he works to develop non-opioid therapeutics for chronic pain relief. bit.ly/3caGkUm
