@rishabrama

Neurosurgery Resident @PennNSG | MD @HarvardMed | BS @RiceUniversity | Passionate about brain tumors, immunotherapy, cell therapy, bioethics

 Philadelphia, PA
scholar.google.com/citations?user=riErOE8AAAAJ&hl=en
Joined September 2013
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  • Following1K
  • Followers623
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🚨1/8 Excited to share the final version of our #meningioma #mesothelin #CART-cell paper, now published @NeuroOnc with corrected proofs! This preclinical work lays the foundation for applying CAR T-cell therapy to aggressive and treatment-refractory meningiomas. Highlights ⬇️
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Emre Kocakavuk, MD, PhD@ekocakavukOct 14
Our study on IDHmut glioma evolution is out now in @Nature nature.com/articles/s41586-0…

Divergent genomic evolution in astrocytomas and oligodendrogliomas

Nature - Longitudinal genomic analyses in patients with astrocytoma or oligodendrioglioma suggest that these two types of tumour differ in the mechanisms by which they become resistant to...

nature.com
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Iahn Cajigas, MD PhD@iahncajigasOct 15
Thank you to my mentors @halpernc, Bijan Pesaran (@pesaranlab), and Michael Beauchamp, to @DanielYoshor and everyone at @PennNSG, staff and residents included. And to my patients, who trust us with the hardest problems. This one is for you. @NINDS #BCI
Penn Neurosurgery@PennNSGOct 14
Congratulations to @iahncajigas on being awarded a 5-year, $3.1M @NIH R01 grant for the proposal, "Microscale Spatial and Temporal Dynamics Of Premotor And Motor Cortex For Enabling Brain Computer Interface Based Motor Restoration Of Arm and Hand Function."
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NS Tumor Section@NSTumorSectionSep 28
Interested in a career in neurosurgical oncology? Join the AANS/CNS Joint Section on Tumors Resident Subcommittee at #CNS2026 for our Fellowship Meet & Greet. 📅 Nov 1 | 8:15–10:45 PM 📍 Flight Club DC 🎟️ FREE registration Register: rebrand.ly/TSCNS2026
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Neurosurgery Podcast
@NSGYPodcastOct 7
🚨 E-bike injuries are on the rise! Drs. @JohnMaaMD and Blake Taylor discuss the case of Amelia Stafford, a 15-year-old who survived a devastating e-bike accident and went on to inspire new legislation to prevent more injuries like hers. Learn why e-bikes behave more like mopeds than bicycles, how helmet use and speed drive traumatic brain injury risk, and how physicians can push for change. And stick around for Dr. Maa's update on new laws in California, New Jersey, and beyond! youtu.be/j41ivQQ3AyQ?si=KX1X… #neurosurgery #meded #neurotrauma @AANSNeuro @AANSNeurosurg @NeurosurgUCSF @UCSFSurgery @AmCollSurgeons @UMneurosurgery @AANSCNStrauma @JPGK_MD @councilsns @neurosurgery @CaNeuroSurgeons @DrDiGiorgio

E-Bike Safety: New Rules of the Road

A conversation with Drs. John Maa and Blake Taylor

youtube.com
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Penn Neurosurgery@PennNSGOct 1
Our residents led us through a fantastic clinical conference this morning where we discussed some very interesting cases that happened at each of our hospitals recently.
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Register today!
NS Tumor Section@NSTumorSectionSep 22
🚨 TUMOR WARS III: Neuro-Onc Jeopardy 🧠⚡ The showdown returns! Med students, residents & fellows will compete in a fast-paced neuro-onc Jeopardy battle. 👉 Register: forms.gle/pY27qDL6pVb9XsMo9
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Eric Topol
@EricTopolSep 10
In 2025, Keytruda (pembrolizumab) was the number one drug for global sales ~$32 billion, targeting PD-1, for cancer immunotherapy. But we didn't know precisely how it works until today @ScienceMagazine science.org/doi/10.1126/scie… science.org/doi/10.1126/scie…
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Rashad Jabarkheel@RJabarkheelSep 6
Great run up the Rocky steps this morning w/ some of our subis! @PennNSG @visishs @rishabrama
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Julia Carnevale
@jccarnevaleAug 13
Incredibly excited to share the first major paper from my lab @carnevale_lab led by postdoc Qi Liu @GladstoneInst @UCSF executing the first ever genome-wide in vivo screens for genetic modifications to enhance human T cell therapies for solid tumors. Now in @Nature: nature.com/articles/s41586-0…

In vivo genome-wide CRISPR screens of human T cells in solid tumours

Nature - An in vivo model that is able to recover human T cells from solid tumours can identify targets to help improve CAR T cell antitumour activity.

nature.com
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Bryan D. Choi MD PhD@BryanDChoiAug 8
Published this week @NatureMedicine, B7-H3 CAR T cells show promise in patients with rGBM! Congrats to all authors for another big step forward for our field. nature.com/articles/s41591-0…
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Visish M. Srinivasan, MD@visishsJul 31
Less than 24 hours to go. In the early AM we start our ascent on Mt. Whitney, the highest peak in the lower 48. As a cerebrovascular neurosurgeon at @PennMedicine @PennNSG, I'm climbing to raise #aneurysm awareness and support @bafound. Help our cause: bit.ly/4pQkgEU
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Penn Neurosurgery@PennNSGJun 18
Congrats to our Neurosurgery Department award winners for this year! @JohnDArenaMD - Resident Clinical Achievement Award and Resident Research Award @visishs - Faculty Rising Star Award Dr. Eric Zager - Outstanding Faculty Educator Award
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Really exciting work from the #Binder/@DrORourke2 group @PennNSG + collaborators highlights how intracerebroventricular CAR-T doesn’t exert anti-tumor effects in isolation but is heavily influenced by the balance of specific cell populations in the CSF.
DrORourke@DrORourke2Jun 15
Remarkable correlative biology defining responders and non-responders to bivalent #GBM #CART cells from our group at @PennCancer @PennMedicine @KitePharma sciencedirect.com/science/ar…
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Penn Neurosurgery@PennNSGJun 1
Now that's a good-looking group! 📸 Check out the new team photo for the @PennMedicine Department of Neurosurgery
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Zihai Li, MD, PhD@ZihaiJun 8
RIP @ProfRAScolyer. A brilliant scientist, physician, and extraordinary human being. His willingness to turn his own #GBM diagnosis into a scientific mission inspired the cancer community worldwide. So much more work remains to be done. #Glioblastoma bbc.com/news/articles/c14yz5…

Richard Scolyer: Australian doctor who underwent world-first brain tumour treatment dies

The melanoma doctor's brain cancer treatment experiment has sparked hope for a breakthrough.

bbc.com
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🚨NEW @NEJM CAR T cells expanding applications! Here CAR T facilitate kidney transplantation in highly sensitized people. dual CD19 + BCMA CAR T enabled kidney transplantation in two highly sensitized patients after reducing anti-donor antibody barriers, with no severe CRS/neurotoxicity. Another CAR T 1st @PennMedicine
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One and done gene therapy for high cholesterol? More data needed but IMHO this is the type of paper that will be taught for years to come. In Vivo Base Editing of PCSK9 with VERVE-102 for Hypercholesterolemia | New England Journal of Medicine nejm.org/doi/full/10.1056/NE…
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Steven Brem
@StevenBremMDMay 14
🧵1/3 Delighted that a scientific dream became reality today with the online publication @NatureComms, "Personalized machine learning-guided radiation dose escalation in newly diagnosed #glioblastoma: prospective pilot study" In an age of AI-everything, this pioneering work @PennCancer @PennRadiology @PennRadOnc @PennNSG from the original Penn Neuro-Oncology Translational Center of Excellence (TCE) could, if validated, could be a game-changer in our approach to #RT of #gliomas, improving survival by harnessing #ML and #AI to predict --- and #PPRT to delay --tumor recurrence, rather than simply focusing #RT on the tumor bed. nature.com/articles/s41467-0…

Personalized machine learning-guided radiation dose escalation in newly diagnosed glioblastoma:...

Nature Communications - As radiotherapy techniques improve so does the ability to more precisely target glioblastoma while sparing neighboring healthy tissue. Here, the authors present a...

nature.com
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John D. Arena, MD@JohnDArenaMDMay 14
CTE cannot be diagnosed during life. Our work published today in @NatureMedicine demonstrates that most individuals meeting proposed clinical criteria do not have evidence of #CTE neuropathology at autopsy (1/5) rdcu.be/fiFKk @PennNSG @PennMedCSO @WillStewNeuro
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Excellent reminder about how basic science, biotech, and academic centers can develop treatment ideas, in this case for RAS and pancreatic cancer. Strong argument for continuing robust funding for US science by the Federal government. nytimes.com/2026/05/12/healt…

How an ‘Impossible’ Idea Led to a Pancreatic Cancer Breakthrough

The new strategy also holds promise for lung and colon tumors. Here’s how scientists discovered it.

nytimes.com
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