Rory Vu Mather (@rvmather) profile picture

MD-PhD Candidate @harvardmitmdphd @mit_hst | Neural Engineering & Pain Research @mghbostonanes @purdonlab @stanfordanes | @WUSTL Alum | Viet đŸłïžâ€đŸŒˆ he/him

Boston, MA
Joined February 2023
Photo by Rory Vu Mather (@rvmather)Photo by Rory Vu Mather (@rvmather)Photo by Rory Vu Mather (@rvmather)Photo by Rory Vu Mather (@rvmather)Photo by Rory Vu Mather (@rvmather)Photo by Rory Vu Mather (@rvmather)Photo by Rory Vu Mather (@rvmather)Photo by Rory Vu Mather (@rvmather)Photo by Rory Vu Mather (@rvmather)Photo by Rory Vu Mather (@rvmather)
Rory Vu Mather retweeted
Excited to share some of my PhD work out today in @NatureCancer! Integrating bulk and single-nucleus genomic approaches, we identify distinct determinants of survival and acquired resistance to ICB versus standard chemoradiation in glioblastoma. nature.com/articles/s43018-0

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Rory Vu Mather retweeted
Excited to share a new perspectives piece on AI in surgery! Instead of making every surgeon an AI expert, we centralized risk assessment to a small team & screened 2200+ GI patients, moving AI from proof-of-concept to real clinical workflows. Read it here: journals.lww.com/aosopen/ful

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Rory Vu Mather retweeted
Happy Holidays from the Purdon Lab! As we wrap up the year, we’re grateful for the collaborations, progress, and community that made this such a meaningful year for our lab. We’re excited to share a few highlights from the past months and to look ahead to what’s coming next.
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Rory Vu Mather retweeted
Please do apply in our rich PHD program if you are interested in computational Neuroscience or Cog Sci. I am hiring and we will have a fantastic time with human neuroimaging and behavioral studies.
🎓 NBRC Ph.D. Admissions 2025 Applications are open! 📅 Last date to apply (Online/Offline): 12 Nov 2025 đŸ’» For more details, visit: nbrc.ac.in/html/nbrc/index.h
 @BricDbt @DBTIndia @rajesh_gokhale @DrSagarSengupta @PsethNbrc @arpansview @urssahu #NBRC #PhDAdmission #Research #Neuroscience
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A new retrospective study indicates that peripheral nerve block administration in orthopaedic surgery is associated with increased short-term opioid prescriptions but a reduced incidence of chronic pain diagnosis at 1 year. bjanaesthesia.org/article/S0

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Prescription opioid harms are worse than the headlines suggest. Our new JAMA Viewpoint shows where FDA oversight hasn’t kept pace—and how to fix it. jamanetwork.com/journals/jam
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Behind-the-scenes: Vijay Sankaran @bloodgenes (left) and first author, Michael Poeschla @michaelpoeschla (right) in the lab!
What are the mechanisms underlying variable expressivity in monogenetic disorders? @bloodgenes, @michaelpoeschla @BostonChildrens show polygenetic modifiers affect penetrance and expressivity in telomere biology disorders. jci.org/articles/view/191107
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Rory Vu Mather retweeted
New publication from our lab investigating hand conditions in pregnancy and postpartum @JHSGlobalOnline. Great work @gabysmith36, Bill Young (MS3), and @ATitanMD!
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A new paper discussing the importance of federal, institutional, and programmatic support for physician scientist trainees. The same can easily apply to biomedical trainees. We as a nation need to support the next generation of doctors and researchers! rdcu.be/etaiE
A powerful new piece in @NatureMedicine by APSA past presidents & board members discusses how funding cuts could disrupt the physician-scientist pipeline and future of biomedical innovation, and outline urgent solutions to safeguard the next generation. rdcu.be/etaiE
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What does surgery reveal about brain resilience? Anesthesiologists Martin Angst & Igor Feinstein are studying older adults before, during & after cardiac surgery to explore how stress impacts the brain—why some recover cognitively while others decline. 🔗brainresilience.stanford.edu

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You’re in great hands America! Here are the 2025 Harvard/MIT MD-PhD graduates who have dedicated their lives to providing the best care to your families & delivering you medical cures from their groundbreaking science. @NIH @NIHDirector_Jay @HHSGov @SecKennedy @harvardmed @MIT
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Rory Vu Mather retweeted
Viewpoint: Expanding the pipeline of social sciences and humanities physician-scientists is both feasible and critical to tackling medicine’s evolving demands. ja.ma/43hWiZq
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To illustrate how brain rhythms may affect cognition, Purdon sings a few bars of “Fly Me to the Moon.” EEG data collected by his team during surgical anesthesia suggest these brain-wave recordings may reflect brain health and could be further developed to help measure resilience.
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Can brain waves during surgery predict who’s at higher risk after? What’s going on: Every year, millions of people die after surgery. Doctors need better ways to spot who’s most at risk—while the surgery is happening.
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Stanford research says using EEG to guide anesthesia in a pediatric patient with Alexander's Disease reduced recovery time by 50%. This approach showed how EEG can improve anesthetic care, particularly for patients with rare neurodevelopmental diseases. hubs.ly/Q03dqtfF0
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New research by @PurdonLab shows that brain waves during surgery, specifically alpha waves (8-12 Hz), may predict recovery risks. EEG monitors, already available in hospitals, could offer real-time, low-burden risk assessments. hubs.ly/Q03cc1yn0
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Here we highlight the impact of physician social scientists and the imperative to expand the pipeline through advocacy and enhanced support for MD-PhD training in the social sciences. The need has never been greater. @NIHAging @NIH @harvardmed @MIT jamanetwork.com/journals/jam

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Rory Vu Mather retweeted
Viewpoint: Expanding the pipeline of social sciences and humanities physician-scientists is both feasible and critical to tackling medicine’s evolving demands. ja.ma/4irTRbz
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Rory Vu Mather retweeted
We are excited that Mae’s case report has been published! Here we show that anesthetic-induced neural signals from EEG can be used as a direct measure of an Alexander’s Disease young patient’s anesthetics sensitivity. pmc.ncbi.nlm.nih.gov/article
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