María Sáez (@saezgam) header
María Sáez (@saezgam) profile picture

María Sáez

@saezgam

Doctor in Neuroscience. I'm something of a scientist myself. Patch clamp aficionado.

Joined May 2018
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Photo by María Sáez (@saezgam)Photo by María Sáez (@saezgam)Photo by María Sáez (@saezgam)Photo by María Sáez (@saezgam)Photo by María Sáez (@saezgam)Photo by María Sáez (@saezgam)Photo by María Sáez (@saezgam)Photo by María Sáez (@saezgam)Photo by María Sáez (@saezgam)Photo by María Sáez (@saezgam)
1/15 Excited to share a new preprint from @RamonReig2 lab at @NeuroAlc! Dopamine enhances multisensory responses in the dorsomedial striatum, with @J_AlegreCortes, @nicomorgens, @crifri1492 and @RobertodelaTor Let’s go with a thread summarizing the story: biorxiv.org/content/10.1101/…
Dopamine enhances multisensory responses in the dorsomedial striatum

Dopamine enhances multisensory responses in the dorsomedial striatum

The brain operates with simultaneous different sensory modalities in order to engage adaptive responses. However, the question of how (and where) multisensory information is integrated remains...

biorxiv.org
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#SciencePhoto_IN “Two Perspectives, One Movement” Author: Olimpia Ortega Lab: @RamonReig2 "A corridor provides simultaneous lateral and ventral views of mouse locomotion to study coordination and subtle motor changes in Parkinson's disease models. With @Basler_AG ace camera."
Image from Instituto de Neurociencias UMH-CSIC (@NeuroAlc)
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#SciencePhoto_IN “Dancing a Waltz” Author: @saezgam Lab: @RamonReig2 "Two medium spiny neurons in the striatum of a mouse, as recorded electrophysiologically, appear to intertwine their dendrites to the rhythm of a waltz. Imaged with a @LeicaMicro Thunder Cicero microscope."
Image from Instituto de Neurociencias UMH-CSIC (@NeuroAlc)
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#SciencePhoto_IN “Axonal Tract” Author: @saezgam Lab: @RamonReig2 "The path taken by neuronal projections from the primary somatosensory cortex through the corpus callosum. This pathway connects the cerebral hemispheres, enabling the exchange of information. @LeicaMicro Thunder."
Image from Instituto de Neurociencias UMH-CSIC (@NeuroAlc)
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#SciencePhoto_IN “Neural pareidolia” Author: @saezgam Lab: @RamonReig2 "Pareidolia is the brain’s tendency to recognize familiar shapes in ambiguous patterns. In this image, the region between the cerebral ventricles resembles the silhouette of an ace of spades. With @LeicaMicro.
Image from Instituto de Neurociencias UMH-CSIC (@NeuroAlc)
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🔥A new study led by @RamonReig2 and @J_AlegreCortes is now published on @iScience_CP 🙌 Researchers reveal how the brain organizes and directs its slowest activity: slow waves🧠 More info 👇 in.umh-csic.es/en/articulos/…
Image from Instituto de Neurociencias UMH-CSIC (@NeuroAlc)
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🔬Un estudio liderado por @NeuroAlc revela cómo el cerebro organiza y dirige sus oscilaciones lentas, unas ondas eléctricas que nunca descansan. 😴Ayuda a comprender mejor estados como el sueño profundo y la anestesia o patologías como la epilepsia. delegacion.comunitatvalencia…
Image from Casa de la Ciència CSIC València (@CSICval)
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María Sáez retweeted
CSIC (@CSIC) profile picture
CSIC
@CSIC23 Sep 2025
🧠 Un estudio del Instituto de #Neurociencias #CSIC-#UMH revela cómo el cerebro organiza y dirige su actividad más lenta   😴 Sus resultados podrían ayudar a comprender mejor el #sueño profundo, la #anestesia o patologías como la #epilepsia   ➡️ tiny.cc/nwxs001
Image from CSIC (@CSIC)
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¡Abierta la preinscripción! 📖Máster en Neurociencia Experimental y Clínica (título propio de la @uvic_ucc) 🖥️ Completamente Online 🗓️ Inicio curso: 27 de octubre de 2025 🔗 Más info: ineurocampus.com/master/173/… #iNeuroCampus #EvidenzeCampus #Neurociencia #Clínica #uvic #uvic_ucc
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#eNeuro | Cholecystokinin Modulates Corticostriatal Transmission and Plasticity in Rodents eneuro.org/content/12/3/ENEU…

Cholecystokinin Modulates Corticostriatal Transmission and Plasticity in Rodents

Recent findings have shifted the view of cholecystokinin (CCK) from being a cellular neuronal marker to being recognized as a crucial neuropeptide pivotal in synaptic plasticity and memory processes....

eneuro.org
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Excited to share a new preprint! This is part of my postdoctoral work with @RamonReig2 and my first modelling paper. biorxiv.org/content/10.1101/… 1/n 🧵
Global and local nature of cortical slow waves

Global and local nature of cortical slow waves

Explaining the macroscopic activity of a recorded neuronal population from its known microscopic properties still poses a great challenge, not just because of the many local agents that shape the...

biorxiv.org
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Global and local nature of cortical slow waves biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Manuscript submitted to @biorxivpreprint ! Stay tunned if you are interested on the study of Slow Waves
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"I NEED THE DMSO!!"
Image from Oded Rechavi (@OdedRechavi)
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Empezamos septiembre con nueva exposición: 'Cajal, Ciencia y Arte', compuesta por facsímiles de dibujos originales del Nobel español conservados en el Legado Cajal del @InstitutoCajal del @CSIC. De lunes a viernes, de 10 a 16 horas. Entrada libre. delegacion.comunitatvalencia…
Image from Casa de la Ciència CSIC València (@CSICval)
Image from Casa de la Ciència CSIC València (@CSICval)
Image from Casa de la Ciència CSIC València (@CSICval)
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#SciencePhoto_IN "The Bat in the Brain" Author: Dr. Dorien Vandael Lab: Dr. Guillermina López-Bendito @GLB_Lab "Tamoxifen inducible Gbx2-mcherry expression in the more rostral part of the mouse brain where the thalamic nuclei take form of a bat. With a @LeicaMicro DMi8."
Image from Instituto de Neurociencias UMH-CSIC (@NeuroAlc)
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To what extent is the activity of a circuit shaped by its local properties or by global states? I explored this question with comp models of cortical populations under the SWO regime. Come to know more this afternoon to poster PS04-173! #FENS2024 @NeuroAlc @SENC_
Image from Javier Alegre Cortés (@J_AlegreCortes)
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María Sáez retweeted
SENC (@SENC_) profile picture
SENC@SENC_25 Jun 2024
🔉👏🏻 El Consejo de Ministros ha aprobado hoy el Real Decreto por el que se crea el Museo #Cajal 👇
Ministerio de Ciencia, Innovación y Universidades (@CienciaGob) profile pictureMinisterio de Ciencia, Innovación y Universidades
@CienciaGob25 Jun 2024
✅ El #CMin aprueba la creación del Museo Cajal para difundir el legado del científico y Premio Nobel español. 🗣️ @DianaMorantR ha destacado la importancia de "reivindicar su figura y conmemorar la ciencia como herramienta de progreso y desarrollo". ciencia.gob.es/Noticias/2024…
Image from Ministerio de Ciencia, Innovación y Universidades (@CienciaGob)
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Of course, the biggest meteorite fallen in Spain (140 kg!) had to fall in Murcia
Image from María Sáez (@saezgam)
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Image from Irena Buzarewicz (@IrenaBuzarewicz)
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The manuscript is almost finished....! If you are coming to #FENS2024, meet me at my poster (27th on the afternoon, PS04-27PM-173) or ping me if you want to talk about how we can study Up states as an opening window to local dynamics.
Image from Javier Alegre Cortés (@J_AlegreCortes)
Javier Alegre Cortés (@J_AlegreCortes) profile pictureJavier Alegre Cortés@J_AlegreCortes1 Mar 2024
I have settled an unrealistic deadline to finish this manuscript and now I'll have to work hard to meet it. Damn you recent past Javi
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