grateful retweeted
this might be my last normal tweet before biotech goes vertical
i'm not a whistleblower. I don't work at Lilly, Novo or any of the big labs
but there is a massive shift happening in human biology right now.
it's sitting in press releases and almost nobody reads them
the last 6 months alone:
- a once-daily pill roughly doubled median survival in metastatic pancreatic cancer (13.2 vs 6.6 months)
- a one-time gene editing infusion cut hereditary angioedema attacks 87%, and 62% of patients stayed attack-free and off all other prevention for 6 months
- a one-time gene edit for cholesterol dropped LDL up to 62%, and it held for over a year
- a personalized mrna vaccine beat keytruda alone in a 1,137 patient melanoma phase 3
- retatrutide hit ~28% weight loss in a phase 3
- an ai-designed drug entered phase 3
- a pill that regrows hair passed its second phase 3
- an immunotherapy that could let some rectal cancer patients skip surgery, chemo and radiation just got fda approved
- a man lived 271 days off dialysis on a pig kidney
- human cells were caught passing chromosome-sized chunks of DNA to their neighbors, and it changes how the neighbors behave
we are on the verge of an era where the human body is a software problem and the update cycle gets shorter everyday
stick around, it's going to get weird
bio/acc
grateful retweeted
It feels like the West has been at war with reality for a few decades now.
So many social problems are downstream of masses of people pretending that reality isn't real.
Comforting lies take precedence over uncomfortable realities. People want to feel good, not do good.
grateful retweeted
I've lived in the same apartment building in Tokyo for 11 years.
I know zero names.
That's normal here. We nod in the elevator. We do not speak.
Then Mike moved in on the third floor.
Ohio. Six-foot-four. Laughs like a truck starting up.
Day 1: He knocked on every door with a plate of cookies.
(In Japan, when you move in, you give your neighbors a small towel. Then you leave. Mike gave cookies. Then he stayed and talked.)
Week 1: He knew everyone's name. Including the dog's.
Then there was Mrs. Sato on the first floor.
She's 84. Her husband passed away ten years ago. She lives alone.
In 11 years, I had never heard her voice.
Every Tuesday, Mike carried her groceries up the steps. She didn't speak English. He didn't speak Japanese.
They talked anyway. Mostly about the photo of her husband by the door.
Then one morning, her curtains stayed closed.
Mike noticed.
Nobody else did. I didn't.
He knocked. No answer. He called the building manager.
She had fallen the night before. She'd been on the floor all night.
She's okay now.
But the building isn't the same.
People say good morning. The elevator has conversations.
Last month, we had our first rooftop potluck. Nobody knew what a potluck was. Mike explained it twice.
Mrs. Sato brought 40 rice balls.
And then she laughed at something Mike said.
That was the first time I ever heard her voice.
Mike moved back to Ohio this week.
On his last morning, the whole building came down to the lobby. Kids. Grandparents. The dog.
Mrs. Sato handed him a box.
Inside: one thousand paper cranes.
In Japan, you fold a thousand cranes for someone you want to protect. Her hands shake. She had been folding them since the day he found her.
Then she said the English sentence she had practiced every day for a week.
"Please... come back."
Mike was crying too hard to answer in English.
So he answered in the Japanese he had been secretly practicing.
"Kanarazu kaette kimasu."
In Japanese, that doesn't mean "I'll visit."
It's what you say when you're coming home.
grateful retweeted
The government today will introduce sweeping censorship that @AlboMP & @AnikaWells lie about. Below she claims the government wants to create a bot army of fake accounts for “research” when the bill clearly intends for them to be used in partisan warfare against fooled citizens.
grateful retweeted
Marcus Aurelius wrote this over 1800 years ago:
“Do not disturb yourself by imagining your whole life at once.”
🔎 Free murder-mystery logic puzzles — a new case every day.
Cross-reference the clues, eliminate the innocent, name the killer.
murderbylogic.com
grateful retweeted
Neverrrrrrrr Everrrrrrr underestimate how much of a blessing it is to have zero health problems and your mom still alive.
grateful retweeted
If I’d had a PE teacher like this, I might have had a brighter childhood and grown into someone who doesn’t live on Twitter 24/7.
grateful retweeted
Marcus Aurelius wrote this over 1800 years ago:
“When you arise in the morning think of what a privilege it is to be alive, to think, to enjoy, to love.”
grateful retweeted
The soy sauce packet in your takeout bag isn't soy sauce. The biggest maker, Kari-Out in New Jersey, lists water, salt, hydrolyzed soy and corn protein, caramel color and sodium benzoate. No fermentation, no brewing. It's made in a couple of days by boiling defatted soy meal in hydrochloric acid, neutralizing it, then adding color and corn syrup so it looks and tastes close enough.
A lot of the bottles on the grocery shelf are the same thing. Kikkoman and the Japanese government went to the UN food standards body years ago and asked that the chemical version not be allowed to use the name soy sauce. The hydrolyzed protein industry and the USDA pushed back and it stayed. The brewed ones say naturally brewed on the label. If the bottle doesn't say it, it isn't.
