Aditya Anand (@scienceaditya) header
Aditya Anand (@scienceaditya) profile picture

Aditya Anand

@scienceaditya

Interested in how cells maintain balance and resilience during periods of stress. Postdoc @Genentech. Alumnus @UCSF - @BerkeleyMCB. 🏳️‍🌈

Joined July 2018
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Photo by Aditya Anand (@scienceaditya)
My first preprint! The huge protein complex eIF2B senses cell stress via its conformation. How is conformational change coordinated across its 10 subunits? We discover that a central helix acts as a fulcrum to allosterically control ISR stress sensing. biorxiv.org/content/10.1101/…
A central helical fulcrum in eIF2B coordinates allosteric regulation of Integrated Stress Response...

A central helical fulcrum in eIF2B coordinates allosteric regulation of Integrated Stress Response...

The Integrated Stress Response (ISR) enables cells to survive a variety of acute stresses, but chronic activation of the ISR underlies age-related diseases. ISR signaling down-regulates translation...

biorxiv.org
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The Peter Walter lab at UCSF is seeking a SRA to work in an exciting collaborative environment on projects related to the Integrative Stress Response. Please RT and share with graduating seniors--we look forward to more in person lab time soon! bit.ly/3sKfvxK
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Interested in learning about industry postdocs? SACNAS@Genentech is hosting an info meeting on March 31st from 4-6pm PST (1hr panel, 1hr networking). If so, please fill out the form below: Interest Form: forms.gle/HVM5FRkN2aRi3j9N7 gene.com/careers/university-…
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An exciting next chapter in the ISRIB story from Walter lab colleagues, w/ a unified look at the mechanism of this cognition-enhancing small molecule. More @biorxivpreprint biorxiv.org/content/10.1101/…
eIF2B Conformation and Assembly State Regulate the Integrated Stress Response

eIF2B Conformation and Assembly State Regulate the Integrated Stress Response

The integrated stress response (ISR) is activated by phosphorylation of the translation initiation factor eIF2 in response to various stress conditions. Phosphorylated eIF2 (eIF2-P) inhibits eIF2’s...

biorxiv.org
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Aditya Anand retweeted
Xin Jin, PhD (@xinjin) profile picture
Xin Jin, PhD@xinjin27 Nov 2020
Our paper is online🦃! no better timing to thank my mentors collaborators and colleagues @zhangf @ArlottaLab Aviv R @jzlevin @seankenneths @Ashwins_shetty @LodatoS_Lab @elisebrobinson grateful to learn from you & proud of the work we accomplished together science.sciencemag.org/conte…
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Aditya Anand retweeted
Zibo Chen (@ZiboChen) profile picture
Zibo Chen@ZiboChen30 Nov 2020
A protein design algorithm that takes both the red pill and the blue pill
Sergey Ovchinnikov (@sokrypton) profile pictureSergey Ovchinnikov@sokrypton30 Nov 2020
Constrain part of the protein, hallucinate the rest? biorxiv.org/content/10.1101/… exciting work from Doug, @sid_thesci_kid, @jueseph, Runze, Ivan, Lukas, and @UWproteindesign!
Image from Sergey Ovchinnikov (@sokrypton)
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In a major scientific breakthrough, the latest version of #AlphaFold has been recognised as a solution to one of biology's grand challenges - the “protein folding problem”. It was validated today at #CASP14, the biennial Critical Assessment of protein Structure Prediction (1/3)
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Aditya Anand retweeted
Zibo Chen (@ZiboChen) profile picture
Zibo Chen@ZiboChen2 Apr 2020
Excited to share CIPHR 🖥️ -- logic gates constructed from scratch, using de novo designed proteins (1/5) science.sciencemag.org/conte…
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Today we are pleased to announce a new policy that provides a fair and unobtrusive way for authors, editors and reviewers to retroactively change their name in papers published in eLife elifesciences.org/inside-eli…

eLife Latest: New policy allows for name changes in published papers

eLife has announced a policy which enables authors, editors and reviewers to retroactively change their name in published papers and accompanying decision letters.

elifesciences.org
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Aditya Anand retweeted
The Associated Press (@AP) profile picture
The Associated Press
@AP8 Nov 2020
"Stacey had the vision." Democrat Stacey Abrams raised millions of dollars to organize and register hundreds of thousands of voters in Georgia, long a GOP stronghold. With her work, President-elect Biden is now on track to carry the state. apne.ws/pjn5Og4
Stacey Abrams credited for boosting Democrats in Georgia

Stacey Abrams credited for boosting Democrats in Georgia

ATLANTA (AP) — Stacey Abrams spent years working to convince political power players that Georgia is a genuine two-party battleground, a Deep South state where the left could compete if it organized...

apnews.com
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Cryo-EM analysis of human mitochondrial Hsp90 in multiple tetrameric states biorxiv.org/cgi/content/shor…
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Aditya Anand retweeted
Eric Topol (@EricTopol) profile picture
Eric Topol
@EricTopol5 Nov 2020
Exciting, elegant, potent 2nd generation #SARSCoV2 neutralization via nanobodies, 2 new reports @ScienceMagazine today science.sciencemag.org/conte… synthetic @UCSF @AashishManglik science.sciencemag.org/conte… camelid @PittTweet @xiang_yufei
Image from Eric Topol (@EricTopol)
Image from Eric Topol (@EricTopol)
Image from Eric Topol (@EricTopol)
Image from Eric Topol (@EricTopol)
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New work out today on the design of new protein inhibitors of #SARSCoV2 led by @tlinsky00 and Daniel-Adriano Silva’s talented team @neoleukin. Happy to provide structural context to these designs! #COVID19 #CryoEM #BlackandSTEM ✊🏾
Science Magazine (@ScienceMagazine) profile pictureScience Magazine
@ScienceMagazine5 Nov 2020
Researchers using a computational approach designed a protein “decoy” that could neutralize #SARSCoV2 infection in cells and protect hamsters from a SARS-CoV-2 challenge. fcld.ly/8kti2lo
Image from Science Magazine (@ScienceMagazine)
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⚠️BREAKING—Huge CDC study says #COVID19 not only caused 285,000 excess deaths— but CDC also found, surprisingly, that it has struck 25-44-year-olds very hard: Their “excess death” rate is up 26.5% over previous years, the largest change for any age group! washingtonpost.com/health/co…
The coronavirus pandemic has caused nearly 300,000 more deaths than expected in a typical year

The coronavirus pandemic has caused nearly 300,000 more deaths than expected in a typical year

About two-thirds are from covid-19, with the rest from other causes, according to a CDC report.

washingtonpost.com
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Meet @LouridoLab postdoc @LizBoydston, who studies Toxoplasma, a pathogen that can recognize and invade cells from many different species—including humans. Read the Q&A: ow.ly/jXhs50ASPI8 #WhiteheadPostdocProfiles
Head and shoulders shot of Elizabeth Boydston next to a quote

ALT Head and shoulders shot of Elizabeth Boydston next to a quote

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The fires across the West Coast are just the latest examples of the very real ways our changing climate is changing our communities. Protecting our planet is on the ballot. Vote like your life depends on it—because it does.
Image from Barack Obama (@BarackObama)
Image from Barack Obama (@BarackObama)
Image from Barack Obama (@BarackObama)
Image from Barack Obama (@BarackObama)
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Excited to share a collaborative project led by the van Kuppeveld lab @UtrechtUni...we studied a Beluga Whale 🐳 coronavirus protein that directs translation machinery to bypass host defenses. nature.com/articles/s41564-0…
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