Psychiatrist | Assistant prof, medical director at @JHPsychedelics. Interested in addiction, psychedelics, behavior change, Bayesian stats.

Joined March 2009
Sandeep Nayak retweeted
‼️ New paper! MDMA "blue Mondays" & "suicide Tuesdays" are familiar phrases in recreational MDMA culture, describing low points in the days post-use. But do these aftereffects actually exist? Current research shows conflicting results. Thread👇
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Sandeep Nayak retweeted
4-arm psilocybin for depression trial out of Pakistan: geneticsmr.com/index.php/gmr…
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4 years and 6 rounds of review later, our mega-entropy analysis is published in Nature Communications! Major points: most previously reported fMRI entropy metrics don't replicate, some do, and they have very little to do with each other, so be specific! xx nature.com/articles/s41467-0…
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Sandeep Nayak retweeted
Presumably, someone somewhere has done the experiment of training a reasoning model exclusively on, say, pre-1900 math, and observing how fruitful it is at developing post-1900 math. This would give some indication of just how useless mathematicians are going forward.
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Sandeep Nayak retweeted
I spoke with Joji Suzuki, who has received a NIDA grant of up to $11M to seek an IND for ibogaine and conduct a Phase I, and possibly Phase IIa, study.
Backed by $11M NIDA Grant, Harvard Moves Forward on Ibogaine for Opioid Use Disorder Research Read more on our website: psychedelicalpha.com/news/ba…
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Grateful that Dr. @PraachiTiwari has agreed to join us as faculty @JHPsychedelics - Praachi is leading an effort to build out transformative translational science at the center. Welcome to the team!!!
Congratulations to Dr. @PraachiTiwari on her promotion to faculty at the Johns Hopkins University School of Medicine! Dr. Tiwari joins the Division of Behavioral Biology and the Center for Psychedelic and Consciousness Research, where she will conduct both preclinical neuroscience and clinical studies to explore translational research on psychedelics.
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Excited that Dr. Gideon Naudé will be joining us as Research Associate @JHPsychedelics - Gideon has been a critical asset in leading both early-stage and and RCT work at the center. Welcome to the team, Gideon!!
Congratulations to Dr. Gideon Naudé on his promotion to Research Associate in the School of Medicine! Dr. Naudé contributed substantially on recent trials of psilocybin-assisted treatment for tobacco smoking cessation and post-treatment Lyme disease. We look forward to his continued research studying pharmacology and drug dependence at the CPCR! 🎉
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Sandeep Nayak retweeted
Excellent work by @DanielCohrsMD and @BShapiroMD 👇🏽
Extending the model findings to a dose-effect analysis yields the figure below. The red curve is just the dose-occupancy curve for sertraline. The blue curve is a dose-5HT curve. As you can see, the blue curve is “smoother”--less flat in the therapeutic dose range, and somewhat less steep at lower doses. Significant changes in 5HT levels are seen within the therapeutic dose range, which provides a potential mechanistic explanation for withdrawal in this range, as well as dose-response effects with SRIs (e.g. therapeutic effects in OCD, anxiety, and side effect trends).
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Sandeep Nayak retweeted
India makes it easy to access opioids. Prescription-only rules often aren't enforced, and cheap painkillers like tramadol and tapentadol are sold over the counter. India also makes it hard to access opioid treatment. The main treatment, opioid agonist therapy, is cheap and works well, but fewer than 2% of people addicted to opioids get it, compared with more than 80% in France. Private psychiatrists are technically allowed to prescribe it, but the drug sits under four conflicting laws and some doctors have been arrested for prescribing it without the right licenses, so almost none offer it. Official policy also pushes patients off the medication within a year or two, even though it's generally recommended people stay on it long term. And more than three quarters of patients at government clinics receive a dose below the WHO's recommended 8 to 24 mg a day. As a result the rate of opioid use is about three times the world average, and at least 77,000 people die from drug-related causes each year. Underdosing and rushing people off the medication makes relapse more likely. That's dangerous, because when someone relapses their tolerance has dropped but their cravings are still strong, so overdoses are more likely.
The last piece of the first issue of @indevmag is out! There are 7.7 million people with opioid use disorder in India. Only 45,000 of them are receiving evidence-based treatment. Akshay Narayanan explains how this happened. indevelopmentmag.substack.co…
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The serendipitous discovery of stimulants in childhood behavioral disorders (1930s) -- hospitalized children given benzedrine for post lumbar puncture headaches were found to have dramatic improvement in school performance and behavior pmc.ncbi.nlm.nih.gov/article…
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Sandeep Nayak retweeted
It's assumed that psychedelic therapy is unique as drug + psychotherapy, but it's not! Here's some ritalin assisted psychotherapy ads from the 50s
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New preprint on BP effects of psilocybin, drawing from 536 high-dose sessions across 14 studies from @JHPsychedelics BP changes generally modest, transient, and self-limiting, similar in magnitude to moderate exercise or sex. We argue for allowing up to 160/100 baseline BP
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Current exclusion criteria (≥140/90 mmHg) aren't supported by these data. We propose: - Broadening eligibility to BP <160/100 mmHg (dosing day flexibility up to 170/105 per MD discretion) - continue to exclude significant CV disease - No HR-based exclusions
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Now out in JoP with @zarmeen_z and Rick Strassman: 5HT-1A blockade with pindolol increases the subjective effects of DMT. This is the first quantitative analysis of 1A blockade on a psychedelic in humans., from data previously collected by Strassman but never analyzed
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Surprisingly, pindolol greatly amplified the hypertensive effects of DMT We speculate that 5-MeO's unique effects profile are due to 1A predominance, and its blockade would remove these, making it more DMT-like
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