biopharma // peptide therapeutics & diagnostics // endocyclic
Los Angeles, CA
Joined January 2019
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One player, one season, one page: read the way a club reads him. Five style bands scored against Big-5 positional peers, the season shot map, the eight players he most resembles, where he lines up and where he actually lives. Erling Haaland's 2025/26 condenses to 27 goals off 25.8 non-penalty xG.
shauntstats-production.up.ra…
been inspired by all of your guys' work
@MarkCarey93
@pranav_m28
@chadha_ishdeep
@CannonStats
@StatmanDave
@fc_mossman
@joeladejola
quite clearly an imitation of the Athletic's beautiful design system, but made available for all to play around with
using this as a playground to see what's possible to ship
great guest, must listen
The new Huberman Lab episode is out: Peptides: The Science, Uses & Safety | Dr. @AbudBakri
0:00 Abud Bakri
3:33 What are Peptides?, Receptors
6:26 BPC-157, Discovery, Animal Proteins
11:19 BPC-157, Animal Data, Regeneration
12:27 Sponsors: Eight Sleep & Lingo
14:51 BPC-157, Regeneration & Healing, Neurological Effects
19:27 Adverse Events, Clinical Trials & Legality of BPC-157
29:41 GLPs & Compounding Pharmacy; Peptides & Gray Market
35:25 Manufacturing, Compounding Pharmacies, Gray Market, Black Market
41:32 Peptides & Tumor Growth?; Angiogenesis
45:17 Sponsor: AG1
47:01 Pharmaceutical Patents, Clinical Trials for BPC-157, Potential Outcomes
54:19 BPC-157 Healing, Patient Experiences
1:01:22 Physician Counsel, FDA Legality, Malpractice
1:07:25 Pinealon, Epithalon, Discovery; Sleep & Cognitive Performance, Risks
1:18:17 Sponsor: Function
1:19:55 Pineal Age Deterioration, Epithalon, Eye Health
1:29:38 Thymus, Age Shrinkage; Thymosin Alpha-1, Immune Function
1:38:13 TB-500; Pet Health; Thymic Peptide Doses, Thymulin, Zinc
1:49:13 Sponsor: LMNT
1:50:33 GHK-Cu (Copper GHK), Collagen
1:55:32 Illness Recovery, Thymic Score, Tool: Blood Test & Immune Cell Counts
2:04:01 Growth Hormone Secretagogues, Age Decline, Cancer Risk, Insulin
2:15:36 GHK-Cu, Topical Cream, Red Light Therapy
2:20:25 GLPs, Discovery, Physical & Cognitive Long-Term Effects, Fertility
2:33:53 Retatrutide; Drug Patents & Nomenclature
2:39:03 Peptides: Women Reproductive Disorders; TBI, Neurologic Effect; Safe Sources
2:45:34 Zero-Cost Support, YouTube, Spotify & Apple Follow, Reviews & Feedback, Sponsors, Protocols Book, Social Media, Neural Network Newsletter
Includes paid partnerships.
skip the telehealth grifting men's health clinic funnel BS and just read this
jamal understands the biochemistry of androgen/endocrinal signaling at a level the clinic funnel guys don't even know exists
- How to optimize your diet is here.
- How to improve mitochondrial energy production is here.
- How to reduce gut irritation, endotoxin, serotonin, and inflammation is here.
- How to improve liver function, bile flow, thyroid conversion, and estrogen clearance is here.
- How to optimize thyroid function naturally is here.
- How to lower cortisol is here.
- How to lower excess serotonin is here.
- How to lower prolactin is here.
- How to reduce estrogen load and aromatase activity is here.
- How to understand progesterone’s role in male physiology is here.
- How to support DHT, 5α-reductase, and androgen signaling is here.
Everything you need to restore your natural testosterone production and understand why testosterone is the final output, not the first lever, is here, except sleep, but I’ve already made enough posts about sleep too.
Use this thread as a case study. Grok’s first reply read as authoritative. It was incomplete. The distinction between DXA-measured LBM and skeletal muscle catabolism wasn’t in the first answer because the first question didn’t surface it. AI is a force multiplier on whatever level of analysis you bring to it. Bring shallow questions, get shallow answers that sound expert.
Valid distinction. DXA LBM includes water, glycogen (~3-4 g water/g), organs like liver, and more—not pure skeletal muscle. Retatrutide's glucagon effect + major hepatic fat clearance (81-86% relative reduction in phase 2 MASLD substudy) shrinks liver mass substantially, which counts as LBM loss on DXA without equaling muscle catabolism. Glycogen/water shifts from caloric deficit add to it.
Still, proportion of total LBM loss to weight loss mirrors other incretins; direct skeletal muscle metrics (MRI/CT) would clarify further. Protein + resistance training remain the proven levers.
What you're describing is real, not in your head. Fin tanks allopregnanolone downstream of 5AR and that hits libido and motivation in a chunk of guys. For some it doesn't bounce back off the drug.
the DHT causes MPB story is also weaker than HIMS makes it sound. HMI-115 (prolactin receptor antibody) is in phase 2 for hair, +14 hairs/cm² at 24wk in phase 1b. fin's pivotal was ~+21 at 52wk. similar ballpark. and blocking PRLR actually raises LH/T/DHT, plus prolactin suppresses 5α-reductase on its own. hair still grows. that shouldn't work if DHT was the whole story.
@BerbarianWizard was the first to alert me on it. No comments on its efficacy for Endo but it's interesting to say the least.
This conflates two completely different industries.
Regulated therapeutic peptides (Novo, Lilly, PeptiDream, the cyclic peptide companies) already have the “verification infrastructure.” It’s called cGMP, ICH stability protocols, USP monographs, release testing, cold chain validation, FDA inspections.
The peptide industry’s biggest bottleneck was never synthesis. It was trust.
We figured out how to manufacture molecules decades ago. What we still haven’t solved is proving, at scale, that what’s inside the vial survives shipping, storage, reconstitution, oxidation, heat exposure, and human handling exactly as advertised.
The next billion-dollar companies won’t be the ones discovering new peptides. They’ll be the ones building the infrastructure layer for verification: real-time stability analytics, chain-of-custody testing, degradation tracking, endotoxin transparency, and consumer-level authentication.
Right now people buy peptides the same way people bought supplements in the 1990s: mostly on faith.
Whoever turns peptide quality from ‘trust me bro’ into measurable infrastructure wins the entire industry.
“Build measurable infrastructure for peptide quality” = reinvent the FDA and Eurofins for products whose entire appeal is regulatory arbitrage.
The minute you make that quality signal credible, you invite the regulator in.