Simon retweeted
Excited to share our new work on transgenerational adaptation science.org/doi/epdf/10.1126… out today spearheaded by outstanding former undergraduate Kathleen Kim NOT C. elegans adapt to repeated generational stresses and no longer display altered fertility, fat content,+ longevity 1/9
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Excited to share a manuscript out online today nature.com/articles/s41590-0…, which we had a supporting role for (as Judy Lieberman is NOT). The manuscript found that emerging tumor repression of immune recognition is reversed by inhibiting DNA methylation. A forthcoming synopsis:1/18
Congrats Hao-Ching, Paul and team! Hard work nicely done!
I am thrilled to announce that my PhD research has been published online in @NatureComms today. rdcu.be/dE8B7
I would like to express my sincere gratitude to my advisor, Dr. Paul Greer, for his valuable guidance and support!
Simon retweeted
I am thrilled to announce that my PhD research has been published online in @NatureComms today. rdcu.be/dE8B7
I would like to express my sincere gratitude to my advisor, Dr. Paul Greer, for his valuable guidance and support!
I'm delighted to share the latest work from our lab in which @HaoChingJiang1 and SungJin Park demonstrate that MS4A1/CD20 functions as a mammalian odorant receptor in a previously uncharacterized population of sensory neurons.
rdcu.be/dE8B7
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Excited to share our paper out online today! We labeled and tracked heritable non-genetic info transmitted from parents to their children. We found that starvation in ancestors leads to transgenerational phenotypes in naïve well-fed descendants, ... 1/9
sciencedirect.com/science/ar…
That’s a cool paper! Congratulations to Liz!
A cool new paper from @pollinalab, Daniel Gilliam (NOT), and @MEGNeuro! Identifying a new neuronal specific repair mechanism in active neurons. How do neurons, which can last 80 years, balance transcription induced DNA damage and repair. nature.com/articles/s41586-0…
Thanks Eric for being the constant resource of support over the years! I would like to share our proposed cover although not selected😊
Congrats @simonyuanwang for his 3rd 1st author paper from my lab! He found hypoxia causes heritable reduced lipids and fertility in C. elegans. Small RNAs were sufficient to induce phenotypes and labeled and tracked an endogenous dsRNA across generations.
cell.com/cell-reports/fullte…
Simon retweeted
The peer-reviewed version of our chromatin evolution paper is now out in @NatureEcoEvo @CRGenomica @xgraubove nature.com/articles/s41559-0…
Link to the PDF: sebepedroslab.org/_files/ugd…
Check out our latest work on chromatin evolution: we reconstruct the origin and evolution of eukaryotic histone marks and modifiers, including their archaeal roots.
biorxiv.org/content/10.1101/…
👇Summary below by @xgraubove.
Simon retweeted
Means, mechanisms and consequences of adenine methylation in DNA go.nature.com/3tFz1gS #Review by Konstantinos Boulias & @EricGreerLab
@BostonChildrens @harvardmed
Simon retweeted
Excited to share a preprint that has been quite a few yrs in the making! We track heritable epigenetic info for the 1st time and show that methylation of the 18S rRNA is passed from parents to kids to set up altered translation 1/13 biorxiv.org/content/10.1101/…
Simon retweeted
The molecular arms race continues: @EricGreerLab @BostonChildrens and @vsv512 @WUSTLmed show how viruses hijack one of our methylating enzymes to methylate their own messenger RNAs, helping them evade our #immune response ms.spr.ly/6010nep1I
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Horizontal Transfer of Histone H3 by Mammalian Cells biorxiv.org/cgi/content/shor… #bioRxiv
No need to say much. 1. An inspiring mentor who treats mentee’s success as his success. 2. A hard-working scientist, you just need to follow his pace and then develop your own. 3. An empathetic person whom you can always talk to any time as chat with a friend.
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The amoeba #Dictyostelium discoideum morphs between unicellular and multicellular states. @EricGreerLab compared epigenetic signatures in both states offers clues to the #evolution of life: ms.spr.ly/6018Vtp1s
Simon retweeted
Study of histone modification and open chromatin in Dictyostelium, from @simonyuanwang, @EricGreerLab and co, to see how changes in chromatin control the switch to multicellularity. Histone deacetylation and methylation inhibitors delay multicellularity genomebiology.biomedcentral.…
Very excited to see the Dictyostelium story online today. Before folding this page, I want to express my gratitude for everyone's help Liz, @IHaoWang1, @lkpino, Henry, Ken, Colette, George, Ben, Paul @Greer_Lab, and @EricGreerLab! This journey is like a marathon, just keep going!
@simonyuanwang's paper examining the role of epigenetics in multicellularity is now published! genomebiology.biomedcentral.… Comparative epigenomic profiling and genetic manipulations identified genes which were necessary and sufficient for multicellularity based on their epigenome 1/7
Simon retweeted
We are tremendously excited to share a new 5-year project led by Linda Zhou doi.org/10.1101/2021.04.23.4…. By way of the 3D genome and inter-chromosomal interactions we discover short tandem repeat instability and heterochromatin silencing on autosomes in fragile X syndrome. 1/n
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Very nice overview: Tutorial: guidelines for the computational analysis of single-cell RNA sequencing data. nature.com/articles/s41596-0…
Simon retweeted
Role of Epigenetics in Unicellular to Multicellular Transition in Dictyostelium
biorxiv.org/cgi/content/shor…