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Just learned that Patrick Stewart has passed away. Such a sad loss. Here he is in one of the best things ever put on television, the Star Trek episode “The Measure of a Man.” I show it to my students in Philosophy and Science Fiction every year.

Our second product is called Blindsight and it will, as the name suggests, enable even those who are completely blind or have never seen to see. It is ready from an engineering standpoint. Just waiting on regulatory approval.

In lieu of flowers, memorial contributions may be made to: Johns Hopkins Alzheimer’s Disease Research Center Fund    alzresearch.org/giving/ Alzheimer’s Foundation of America Caregiver Resources     alzfdn.org/donate/ Photo Credit: Tommy Garcia

We’re glowing with excitement over the new MacBook Pro. You’ve gotta touch it to believe it.

Today, in collaboration with Anthropic, we’re excited to share rapid initial progress towards an antibody treatment for food allergy, which affects over 200 million people worldwide, discovered with the help of Claude. At Divergence Labs, we believe that AI can unlock the next generation of antibody therapeutics with more effective mechanisms than before. Such mechanisms are urgently needed in food allergy, which involve overcoming one of the tightest affinity protein pairs in immunology, IgE and its receptor FcεRI, on mast cells. Treatment with Xolair—the only approved antibody for food allergy—sequesters circulating IgE, but mast cells remain sensitized for weeks to months due to the extraordinarily slow dissociation of IgE from FcεRI. We envision a treatment that actively pulls IgE off of FcεRI, without waiting for natural dissociation. Like picking a lock, this requires the right combination of geometry and force. Our research team, working with Claude, ideated on mechanisms to accomplish this disruption, and converged on an antibody format with two arms with different functions and epitopes. Within one month, we designed, synthesized, and experimentally confirmed the biophysical function of the two arms, which we are now assembling into full therapeutic formats.

AI is now taking on some of the hardest open problems that scientists have posed. But research is broader than solving problems. Can AI also propose research questions that experts find genuinely interesting? We built After42 to find out. Experts judged 45 of its 135 final questions genuinely interesting, across mathematics, statistics, theoretical computer science, and physics, with wide variation across subfields. The key idea: develop questions by trying to solve them. We also asked whether AI can judge which questions are interesting. We find that model judges' top choices align with expert consensus but do not consistently capture individual experts' preferences. We release the expert-assessed questions as an open resource for researchers to discuss, refine, and pursue, as a step toward integrating AI into the broader research enterprise. after42.org

Up to now all presentations I saw were very well presented and formatted, but all were also heavily prepared with the help of LLMs. I feel like we are loosing the nuances of each individual, what makes us unique, including our imperfections. #EMNLP2026

Mark Zuckerberg explains why he thinks Elon Musk got it right when he cut 80% of Twitter's staff: "Elon led a push early on to make Twitter a lot leaner. You can agree or disagree with exactly all the tactics, but a lot of the specific principles that he pushed on around basically trying to make the organization more technical, around decreasing the distance between engineers of the company and him, fewer layers of management, I think those were generally good changes" "I also think that it was probably good for the industry that he made those changes because my sense is that there were a lot of other people who thought those were good changes but who may have been a little shy about doing them" "Just in my conversations with other founders and how people have reacted to the things that we've done, what I've heard from a lot of folks is when someone like you, when I wrote the letter outlining the organizational changes I wanted to make back in March and when people see what Elon is doing, that gives people the ability to think through how to shape their organizations in a way that can be good for the industry and make all these companies more productive over time" "That was one where I think he was quite ahead of a bunch of the other companies on. Certainly his actions led me and I think a lot of other folks in the industry to think about, hey, are we kind of doing this as much as we should? Could we make our companies better by pushing on some of these same principles?" If you're new here, @GeniusGTX is a gallery for the greatest minds in economics, psychology, and history. Follow along for more similar content.

Me next Monday.

2026 has been about 5 years so far

Whoever thought about setting up security cameras watching the tv connections is a genius.