Advocate for Stargardtians - Sharing retina research advances, focused on Stargardt disease. #stargardt. By @rrelyea
Bellevue, WA
Joined February 2018
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Really enjoyed this new podcast episode with @quailty.
Three great segments. About his book about a country of all blind people. The history of braille. And living with low vision.
podcasts.apple.com/us/podcas…
Great news for people with age related macular degeneration. First FDA approved therapy for people living with geographic atrophy.
We are thrilled to announce the FDA has approved the first-ever therapy for people living with #GeographicAtrophy (GA).
GA is an irreversible and progressive retinal disease that impacts over a million people in the U.S.
5 years ago, I started tweeting additionally as @stargardtp focused on stargardtians and research advances for therapies and cures. Still much work to do! #abca4 #stargardt
Rob Relyea (Stargardtians) retweeted
Ascidian’s lead program addresses mutations of the #ABCA4 gene that lead to inherited eye disorders such as #Stargardtdisease, a genetically driven form of vision loss with no FDA-approved therapies.
Rob Relyea (Stargardtians) retweeted
Researchers home in on a new cause of Stargardt disease @ISSCR doi.org/gq44b7 medicalxpress.com/news/2022-…
Rob Relyea (Stargardtians) retweeted
Stargardt disease causes increasing loss of central and night vision. Researchers from our intramural program developed a model to better understand Stargardt and to develop treatments for it. Read more: nei.nih.gov/about/news-and-e…
#NEIResearchNews
ALT Lipid deposits in a cross-section of retinal pigment epithelium (the layer of tissue that protects and nourishes the light-sensing part of the eye). These lipid deposits are toxic to cells and are like those found in people with Stargardt disease. Image courtesy of the National Eye Institute. Image credit: Kapil Bharti, Ph.D.
Rob Relyea (Stargardtians) retweeted
In this week's #EyeOnTheCurePodcast episode, host Ben chats with Rando Allikmets, PhD, from @Columbia, about his remarkable and serendipitous discovery more than two decades ago of #ABCA4, the gene associated with #Stargardt disease. FightingBlindness.org/news/e…
ALT Eye on the Cure Podcast logo at the top with a headshot of Dr. Rando Allikmets below and text to the right that says, "EPISODE 37: Rando Allikmets, PhD" with more text below that says, "Listen to the Latest Podcast Episode Out Now."
Believe this is about crispr-cas9 based study and lca10. Hopefully there are lessons to learn from the bad results?
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Stargardt research progress. Human model.
nei.nih.gov/about/news-and-e…
"1st report where loss of ABCA4 function in human RPE has been associated with intracellular lipid deposits in those cells, w/o exposure to ABCA4 mutant photoreceptor outer segments. Over time, these lipid deposits may contribute to RPE atrophy => photoreceptor degeneration."
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Not sure why this wasn’t tweeted by @NatEyeInstitute yet… I got the link via an email newsletter from NEI that you can subscribe to via:
list.nih.gov/cgi-bin/wa.exe?…
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Promising pre-print of non-viral gene therapy for abca4 in mice - stargardt.
doi.org/10.1016/j.omtn.2022.…
Rob Relyea (Stargardtians) retweeted
@belite_bio submits an IND application to the FDA to support Phase 3 development of LBS-008, the Company’s orally administered treatment for #Stargardt Disease (STGD1).
Article: bit.ly/3PITo6h
#ClinicalTrials #Ophthalmology
Rob Relyea (Stargardtians) retweeted
@Nanoscope's MCO-010 clinical trial offers hope for patients with #Stargardt macular degeneration. Patients with severe #visionloss typically lack sufficient light-sensing photoreceptor neurons needed to qualify for experimental ABCA4 #therapies.
Story: bit.ly/3csTyAr
Didn't realize that it takes so long to get a service dog!
teapawt.net/Vivian_Cheung2/status/…
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Covid testing help for visually impaired:
Testing for #COVID19 can be challenging for those that are visually impaired. The Administration launched a new initiative to distribute free, accessible home tests to those who are blind or have low vision. The tests use an app to provide audible results
acl.gov/covid19/tests-people…
I'm building a clinical trial viewer/search tool for a variety of uses. If this is interesting to you, follow my other account: @rrelyea ...and get in touch.
Link to an example with a prebuilt list of retinal conditional search terms: rrelyea.github.io/trials/?qs…
Picture:
Rob Relyea (Stargardtians) retweeted
Tomorrow I will be sharing the latest results on QR-1011 at #ARVO2022. QR-1011 is a splicing-modulating therapy for the most recurrent severe intronic variant causing Stargardt disease. Come to see!
I imagine @fightblindness already has seen this request for feedback on antisense oligonucleotides from @asprgov.
teapawt.net/ASPRgov/status/1520103…
ASPR is soliciting perspectives from experts in the field of synthetic DNA to help shape the proposed updated Screening Framework Guidance for Providers and Users of Synthetic Oligonucleotides. View the proposed changes & submit your feedback: aspr.hhs.gov/legal/syndna/Pa…
