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Lorenzo (@suffro_) profile picture

Lorenzo

@suffro_

I like to build stuff, and sometimes, it works. Biology & IT - From 🇮🇹

 Italy
github.com/suffro
Joined October 2018
  • Tweets11
  • Following124
  • Followers32
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Photo by Lorenzo (@suffro_)Photo by Lorenzo (@suffro_)Photo by Lorenzo (@suffro_)
Lorenzo retweeted
antirez (@antirez) profile picture
antirez@antirezNov 9
I already see clear signs that who is refusing AI assistance for programming it is starting to lag behind in a significant way, where this means: they are living in a bubble where losing work will happen faster compared to the other folks.
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Liatir 0.4.0 is out. Adding a simulation suite for biology and drug discovery: Vina docking, GNINA rescoring, OpenMM dynamics, MDAnalysis/ProLIF, PySB, COBRApy and PhysiCell. Check it out: liatir.com
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Manually reviewing all AI-generated code is counterproductive, I talked about this on my personal blog: notes.suffro.com/posts/why-i…

Why I Don't Review Every Line of AI-Generated Code · Suffro’s Notes

I think understanding the system, testing it properly, managing agent context, and keeping strong computer science fundamentals matter more than manually inspecting every generated line.

notes.suffro.com
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New Liatir scientific showcase: benchmarking scGPT + Geneformer against PCA, Harmony and scVI on PBMC + Pancreas — fully run, tracked and reproduced through Liatir. Results + artifacts: liatir.com/showcases/single-…
Image from Lorenzo (@suffro_)
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I’ve been building Liatir, a local-first desktop app for bioinformatics: native tools, local AI models, custom plugins and visual pipelines, all running locally on your own machine. Built with Rust/Tauri. I’ve now open-sourced it. github.com/Liatir/liatir-app
Image from Lorenzo (@suffro_)
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Built DecGuard, an open-source reliability layer for probabilistic AI decisions. Contracts, calibration, fuzzing, regression tests, replay and CI gates — across interchangeable backends like Kev and Jev. decguard.com
DecGuard

DecGuard

Reliability testing for probabilistic AI decisions: decision contracts, calibration, metamorphic fuzzing, regression gates and offline production checks.

decguard.com
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I published a technical research article: Cross-backbone decision behavior can transfer without target labels, but the learned shared DecisionCore itself did not show reusable value. Paper: doi.org/10.5281/zenodo.22947… Repo: github.com/suffro/decport

Distinguishing Cross-Backbone Decision-Behavior Transfer from Frozen-Core Portability

DecPort investigates two related questions: whether input-specific probabilistic decision behavior can be transferred across heterogeneous frozen language-model backbones without target labels, and...

zenodo.org
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I open-sourced Scrollcase: a way to package Python, Node or native apps into self-contained, signed boxes with locked dependencies. No Python, Node, compiler, dependencies, Docker or anything needed on the target machine. #opensource github.com/suffro/scrollcase
GitHub - suffro/scrollcase: Pack entire environments as self-contained boxes (eg. an AI Model)....

GitHub - suffro/scrollcase: Pack entire environments as self-contained boxes (eg. an AI Model)....

Pack entire environments as self-contained boxes (eg. an AI Model). Pinned, validated, signed and air-gappable, for macOS Metal, Linux and Windows (CPU and CUDA). - suffro/scrollcase

github.com
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I was already keeping repo context in Markdown because I didn’t want it locked inside one AI tool. I turned that workflow into Syngraphe: Git-native context behind AGENTS.md, with checks, stats and a GitHub Action. #opensource github.com/suffro/syngraphe
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